Researchers have developed three new antibiotics from scorpion venom and habanero peppers to combat tuberculosis and other drug-resistant pathogens. Researchers from the National Autonomous University of Mexico (UNAM) have identified new ways to combat tuberculosis and reduce bacterial resistance, developing three new antibiotics derived from scorpion venom and habanero peppers. A team led by Lourival Domingos Possani Postay, from the Institute of Biotechnology's Morelos campus, created two drugs that demonstrated efficacy against the bacterium, responsible for tuberculosis, as well as against, a microorganism that in hospital environments can cause various clinical complications, from skin infections to potentially fatal diseases such as pneumonia, meningitis, septicemia, and endocarditis. The antibiotics were derived from the venom of the scorpion, native to the state of Veracruz. The team was able to isolate two colorless molecules called benzoquinones--heterocyclic compounds that do not contain amino acids--from the arachnid's toxin.

Plus: After years of insults, Anthropic and SpaceX have teamed up. IVF has brought millions of babies into the world over the last four decades. But the process can still be slow, painful, and expensive--and far from guaranteed to work. Now, a wave of new technologies aims to change that. Researchers are using AI to identify promising sperm and embryos, developing robotic systems that could automate parts of the IVF process, and even exploring controversial genetic editing techniques designed to prevent inherited disease. The technologies could make IVF more effective and accessible.

Boundary condition tuning is a fundamental step in patient-specific cardiovascular modeling. Despite an increase in offline training cost, recent methods in data-driven variational inference can efficiently estimate the joint posterior distribution of boundary conditions, with amortization of training efforts over clinical targets. However, even the most modern approaches fall short in two important scenarios: open-loop models with known mean flow and assumed waveform shapes, and anatomies affected by vascular lesions where segmentation influences the reachability of pressure or flow split targets. In both cases, boundary conditions cannot be tuned in isolation. We introduce a general amortized inference framework based on probabilistic flow that treats clinical targets, inflow features, and point cloud embeddings of patient-specific anatomies as either conditioning variables or quantities to be jointly estimated. We demonstrate the approach on two patient-specific models: an aorto-iliac bifurcation with varying stenosis locations and severity, and a coronary arterial tree.

Fungal diseases are a major threat to the global banana supply. Breakthroughs, discoveries, and DIY tips sent six days a week. The popular fruit is threatened by a fungal disease called Fusarium wilt of banana (FWB), which blocks the flow of nutrients and makes it wilt. In the 1950s, the pathogen even made one species-Gros Michel bananas-functionally extinct. Fear not though, scientists are on it.

Lifting weights can keep you carrying groceries and riding bikes even as you get older. To join or not to join a gym: That is the question. If you opt out of building a home gym, you can join a club and have access to more weights and machines. Friends and classes motivate you to keep coming, and that monthly bill keeps you disciplined. On the other hand, gym memberships are steep, workouts can get hijacked by bullies, and going to the gym is an additional commute.

Breakthroughs, discoveries, and DIY tips sent six days a week. Whether it's the ocean's deepest hydrothermal vents or tall mountain peaks, bacteria is likely surviving and thriving. Ice caves can host a wide variety of microorganisms and offer biologists a bevy of genetic diversity that still has to be studied. And it could help save lives. A team of scientists in Romania tested antibiotic resistance profiles with a bacterial strain that was hidden in a 5,000-year-old layer of ice inside an underground ice cave.

Effective resistances have a broad range of algorithmic implications.

César de la Fuente is on a mission to combat antimicrobial resistance by looking at nature's own solutions. César de la Fuente is an associate professor at the University of Pennsylvania, where he leads the Machine Biology Group. When he was just a teenager trying to decide what to do with his life, César de la Fuente compiled a list of the world's biggest problems. He ranked them inversely by how much money governments were spending to solve them. Antimicrobial resistance topped the list. Twenty years on, the problem has not gone away.