Abstract--A complete mechatronic design of a minimal configuration brachiation robot is presented. The robot consists of a single rigid rod with gripper mechanisms attached to both ends. The grippers are used to hang the robot on a horizontal bar on which it swings or rotates. The motion is imposed by repositioning the robot's center of mass, which is performed using a crank-slide mechanism. Based on a non-linear model, an optimal control strategy is proposed, for repositioning the center of mass in a bang-bang manner . Consequently, utilizing the concept of input-output linearization, a continuous control strategy is proposed that takes into account the limited torque of the crank-slide mechanism and its geometry. An increased attention is paid to energy accumulation towards the subsequent jump stage of the brachiation. These two strategies are validated and compared in simulations. The continuous control strategy is then also implemented within a low-cost STM32-based control system, and both the swing and rotation stages of the brachiation motion are experimentally validated. Brachiation is a form of motion used by primates to move from one branch to another.

Recent works on object removal and insertion have enhanced their performance by handling object effects such as shadows and reflections, using diffusion models trained on counterfactual datasets. However, the performance impact of applying classifier-free guidance to handle object effects across removal and insertion tasks within a unified model remains largely unexplored. T o address this gap and improve efficiency in composite editing, we propose CrimEdit, which jointly trains the task embeddings for removal and insertion within a single model and leverages them in a classifier-free guidance scheme--enhancing the removal of both objects and their effects, and enabling controllable synthesis of object effects during insertion. CrimEdit also extends these two task prompts to be applied to spatially distinct regions, enabling object movement (repositioning) within a single denoising step. By employing both guidance techniques, extensive experiments show that CrimEdit achieves superior object removal, controllable effect insertion, and efficient object movement--without requiring additional training or separate removal and insertion stages.

-- Enabling robots to grasp and reposition human limbs can significantly enhance their ability to provide assistive care to individuals with severe mobility impairments, particularly in tasks such as robot-assisted bed bathing and dressing. However, existing assistive robotics solutions often assume that the human remains static or quasi-static, limiting their effectiveness. T o address this issue, we present Manip4Care, a modular simulation pipeline that enables robotic manipulators to grasp and reposition human limbs effectively. Our approach features a physics simulator equipped with built-in techniques for grasping and repositioning while considering biomechanical and collision avoidance constraints. Our grasping method employs antipodal sampling with force closure to grasp limbs, and our repositioning system utilizes the Model Predictive Path Integral (MPPI) and vector-field-based control method to generate motion trajectories under collision avoidance and biomechanical constraints. We evaluate this approach across various limb manipulation tasks in both supine and sitting positions and compare outcomes for different age groups with differing shoulder joint limits. Additionally, we demonstrate our approach for limb manipulation using a real-world mannequin and further showcase its effectiveness in bed bathing tasks. Our implementation is available at https://github.com/

Drug repositioning aims to identify potential new indications for existing drugs to reduce the time and financial costs associated with developing new drugs. Most existing deep learning-based drug repositioning methods predominantly utilize graph-based representations. However, graph-based drug repositioning methods struggle to perform effective inference in cold-start scenarios involving novel drugs because of the lack of association information with the diseases. Unlike traditional graph-based approaches, we propose a bidirectional behavior learning strategy for drug repositioning, known as BiBLDR. This innovative framework redefines drug repositioning as a behavior sequential learning task to capture drug-disease interaction patterns. First, we construct bidirectional behavioral sequences based on drug and disease sides. The consideration of bidirectional information ensures a more meticulous and rigorous characterization of the behavioral sequences. Subsequently, we propose a two-stage strategy for drug repositioning. In the first stage, we construct prototype spaces to characterize the representational attributes of drugs and diseases. In the second stage, these refined prototypes and bidirectional behavior sequence data are leveraged to predict potential drug-disease associations. Based on this learning approach, the model can more robustly and precisely capture the interactive relationships between drug and disease features from bidirectional behavioral sequences. Extensive experiments demonstrate that our method achieves state-of-the-art performance on benchmark datasets. Meanwhile, BiBLDR demonstrates significantly superior performance compared to previous methods in cold-start scenarios. Our code is published in https://github.com/Renyeeah/BiBLDR.

Repositioning drug-disease relationships has always been a hot field of research. However, actual cases of biologically validated drug relocation remain very limited, and existing models have not yet fully utilized the structural information of the drug. Furthermore, most repositioning models are only used to complete the relationship matrix, and their practicality is poor when dealing with drug cold start problems. This paper proposes a structure-enhanced multimodal relationship prediction model (SMRP). SMPR is based on the SMILE structure of the drug, using the Mol2VEC method to generate drug embedded representations, and learn disease embedded representations through heterogeneous network graph neural networks. Ultimately, a drug-disease relationship matrix is constructed. In addition, to reduce the difficulty of users' use, SMPR also provides a cold start interface based on structural similarity based on reposition results to simply and quickly predict drug-related diseases. The repositioning ability and cold start capability of the model are verified from multiple perspectives. While the AUC and ACUPR scores of repositioning reach 99% and 61% respectively, the AUC of cold start achieve 80%. In particular, the cold start Recall indicator can reach more than 70%, which means that SMPR is more sensitive to positive samples. Finally, case analysis is used to verify the practical value of the model and visual analysis directly demonstrates the improvement of the structure to the model. For quick use, we also provide local deployment of the model and package it into an executable program.

Pioneering companies such as Waymo have deployed robo-taxi services in several U.S. cities. These robo-taxis are electric vehicles, and their operations require the joint optimization of ride matching, vehicle repositioning, and charging scheduling in a stochastic environment. We model the operations of the ride-hailing system with robo-taxis as a discrete-time, average reward Markov Decision Process with infinite horizon. As the fleet size grows, the dispatching is challenging as the set of system state and the fleet dispatching action set grow exponentially with the number of vehicles. To address this, we introduce a scalable deep reinforcement learning algorithm, called Atomic Proximal Policy Optimization (Atomic-PPO), that reduces the action space using atomic action decomposition. We evaluate our algorithm using real-world NYC for-hire vehicle data and we measure the performance using the long-run average reward achieved by the dispatching policy relative to a fluid-based reward upper bound. Our experiments demonstrate the superior performance of our Atomic-PPO compared to benchmarks. Furthermore, we conduct extensive numerical experiments to analyze the efficient allocation of charging facilities and assess the impact of vehicle range and charger speed on fleet performance.

We consider a network inventory problem motivated by one-way, on-demand vehicle sharing services. Due to uncertainties in both demand and returns, as well as a fixed number of rental units across an $n$-location network, the service provider must periodically reposition vehicles to match supply with demand spatially while minimizing costs. The optimal repositioning policy under a general $n$-location network is intractable without knowing the optimal value function. We introduce the best base-stock repositioning policy as a generalization of the classical inventory control policy to $n$ dimensions, and establish its asymptotic optimality in two distinct limiting regimes under general network structures. We present reformulations to efficiently compute this best base-stock policy in an offline setting with pre-collected data. In the online setting, we show that a natural Lipschitz-bandit approach achieves a regret guarantee of $\widetilde{O}(T^{\frac{n}{n+1}})$, which suffers from the exponential dependence on $n$. We illustrate the challenges of learning with censored data in networked systems through a regret lower bound analysis and by demonstrating the suboptimality of alternative algorithmic approaches. Motivated by these challenges, we propose an Online Gradient Repositioning algorithm that relies solely on censored demand. Under a mild cost-structure assumption, we prove that it attains an optimal regret of $O(n^{2.5} \sqrt{T})$, which matches the regret lower bound in $T$ and achieves only polynomial dependence on $n$. The key algorithmic innovation involves proposing surrogate costs to disentangle intertemporal dependencies and leveraging dual solutions to find the gradient of policy change. Numerical experiments demonstrate the effectiveness of our proposed methods.

A versatile robot working in a domestic environment based on a deep neural network (DNN) is currently attracting attention. One of the roles expected for domestic robots is caregiving for a human. In particular, we focus on repositioning care because repositioning plays a fundamental role in supporting the health and quality of life of individuals with limited mobility. However, generating motions of the repositioning care, avoiding applying force to non-target parts and applying appropriate force to target parts, remains challenging. In this study, we proposed a DNN-based architecture using visual and somatosensory attention mechanisms that can generate dual-arm repositioning motions which involve different sequential policies of interaction force; contact-less reaching and contact-based assisting motions. We used the humanoid robot Dry-AIREC, which features the capability to adjust joint impedance dynamically. In the experiment, the repositioning assistance from the supine position to the sitting position was conducted by Dry-AIREC. The trained model, utilizing the proposed architecture, successfully guided the robot's hand to the back of the mannequin without excessive contact force on the mannequin and provided adequate support and appropriate contact for postural adjustment.

Drug repositioning is an economically efficient strategy used to discover new indications for existing drugs beyond their original approvals, expanding their applicability and usage to address challenges in disease treatment. In recent years, deep-learning techniques for drug repositioning have gained much attention. While most deep learning-based research methods focus on encoding drugs and diseases by extracting feature information from neighbors in the network, they often pay little attention to the potential relationships between the features of drugs and diseases, leading to imprecise encoding of drugs and diseases. To address this, we design a dual-feature drug repositioning neural network (DFDRNN) model to achieve precise encoding of drugs and diseases. DFDRNN uses two features to represent drugs and diseases: the similarity feature and the association feature. The model incorporates a self-attention mechanism to design two dual-feature extraction modules for achieving precisely encoding of drugs and diseases: the intra-domain dual-feature extraction (IntraDDFE) module and the inter-domain dual-feature extraction (InterDDFE) module. The IntraDDFE module extracts features from a single domain (drug or disease domain), while the InterDDFE module extracts features from the mixed domain (drug and disease domain). In particular, the feature is changed by InterDDFE, ensuring a precise encoding of drugs and diseases. Finally, a cross-dual-domain decoder is designed to predict drug-disease associations in both the drug and disease domains. Compared to six state-of-the-art methods, DFDRNN outperforms others on four benchmark datasets, with an average AUROC of 0.946 and an average AUPR of 0.597.

Many applications, e.g., in shared mobility, require coordinating a large number of agents. Mean-field reinforcement learning addresses the resulting scalability challenge by optimizing the policy of a representative agent interacting with the infinite population of identical agents instead of considering individual pairwise interactions. In this paper, we address an important generalization where there exist global constraints on the distribution of agents (e.g., requiring capacity constraints or minimum coverage requirements to be met). We propose Safe-M$^3$-UCRL, the first model-based mean-field reinforcement learning algorithm that attains safe policies even in the case of unknown transitions. As a key ingredient, it uses epistemic uncertainty in the transition model within a log-barrier approach to ensure pessimistic constraints satisfaction with high probability. Beyond the synthetic swarm motion benchmark, we showcase Safe-M$^3$-UCRL on the vehicle repositioning problem faced by many shared mobility operators and evaluate its performance through simulations built on vehicle trajectory data from a service provider in Shenzhen. Our algorithm effectively meets the demand in critical areas while ensuring service accessibility in regions with low demand.