Dose prediction is an area of ongoing research that facilitates radiotherapy planning. Most commercial models utilise imaging data and intense computing resources. This study aimed to predict the dose-volume of rectum and bladder from volumes of target, at-risk structure organs and their overlap regions using machine learning. Dose-volume information of 94 patients with prostate cancer planned for 6000cGy in 20 fractions was exported from the treatment planning system as text files and mined to create a training dataset. Several statistical modelling, machine learning methods, and a new fuzzy rule-based prediction (FRBP) model were explored and validated on an independent dataset of 39 patients. The median absolute error was 2.0%-3.7% for bladder and 1.7-2.4% for rectum in the 4000-6420cGy range. For 5300cGy, 5600cGy and 6000cGy, the median difference was less than 2.5% for rectum and 3.8% for bladder. The FRBP model produced errors of 1.2%, 1.3%, 0.9% and 1.6%, 1.2%, 0.1% for the rectum and bladder respectively at these dose levels. These findings indicate feasibility of obtaining accurate predictions of the clinically important dose-volume parameters for rectum and bladder using just the volumes of these structures.

Soft robots have found extensive applications in the medical field, particularly in rehabilitation exercises, assisted grasping, and artificial organs. Despite significant advancements in simulating various components of the digestive system, the rectum has been largely neglected due to societal stigma. This study seeks to address this gap by developing soft circular muscle actuators (CMAs) and rectum models to replicate the defecation process. Using soft materials, both the rectum and the actuators were fabricated to enable seamless integration and attachment. We designed, fabricated, and tested three types of CMAs and compared them to the simulated results. A pneumatic system was employed to control the actuators, and simulated stool was synthesized using sodium alginate and calcium chloride. Experimental results indicated that the third type of actuator exhibited superior performance in terms of area contraction and pressure generation. The successful simulation of the defecation process highlights the potential of these soft actuators in biomedical applications, providing a foundation for further research and development in the field of soft robotics.

Fecal incontinence, arising from a myriad of pathogenic mechanisms, has attracted considerable global attention. Despite its significance, the replication of the defecatory system for studying fecal incontinence mechanisms remains limited largely due to social stigma and taboos. Inspired by the rectum's functionalities, we have developed a soft robotic system, encompassing a power supply, pressure sensing, data acquisition systems, a flushing mechanism, a stage, and a rectal module. The innovative soft rectal module includes actuators inspired by sphincter muscles, both soft and rigid covers, and soft rectum mold. The rectal mold, fabricated from materials that closely mimic human rectal tissue, is produced using the mold replication fabrication method. Both the soft and rigid components of the mold are realized through the application of 3D-printing technology. The sphincter muscles-inspired actuators featuring double-layer pouch structures are modeled and optimized based on multilayer perceptron methods aiming to obtain high contractions ratios (100 %), high generated pressure (9.8 kPa), and small recovery time (3 s). Upon assembly, this defecation robot is capable of smoothly expelling liquid faeces, performing controlled solid fecal cutting, and defecating extremely solid long faeces, thus closely replicating the human rectum and anal canal's functions. This defecation robot has the potential to assist humans in understanding the complex defecation system and contribute to the development of well-being devices related to defecation.

Rectal cancer is one of the most common diseases and a major cause of mortality. For deciding rectal cancer treatment plans, T-staging is important. However, evaluating the index from preoperative MRI images requires high radiologists' skill and experience. Therefore, the aim of this study is to segment the mesorectum, rectum, and rectal cancer region so that the system can predict T-stage from segmentation results. Generally, shortage of large and diverse dataset and high quality annotation are known to be the bottlenecks in computer aided diagnostics development. Regarding rectal cancer, advanced cancer images are very rare, and per-pixel annotation requires high radiologists' skill and time. Therefore, it is not feasible to collect comprehensive disease patterns in a training dataset. To tackle this, we propose two kinds of approaches of image synthesis-based late stage cancer augmentation and semi-supervised learning which is designed for T-stage prediction. In the image synthesis data augmentation approach, we generated advanced cancer images from labels. The real cancer labels were deformed to resemble advanced cancer labels by artificial cancer progress simulation. Next, we introduce a T-staging loss which enables us to train segmentation models from per-image T-stage labels. The loss works to keep inclusion/invasion relationships between rectum and cancer region consistent to the ground truth T-stage. The verification tests show that the proposed method obtains the best sensitivity (0.76) and specificity (0.80) in distinguishing between over T3 stage and underT2. In the ablation studies, our semi-supervised learning approach with the T-staging loss improved specificity by 0.13. Adding the image synthesis-based data augmentation improved the DICE score of invasion cancer area by 0.08 from baseline.

Data augmentation (DA) is a key factor in medical image analysis, such as in prostate cancer (PCa) detection on magnetic resonance images. State-of-the-art computer-aided diagnosis systems still rely on simplistic spatial transformations to preserve the pathological label post transformation. However, such augmentations do not substantially increase the organ as well as tumor shape variability in the training set, limiting the model's ability to generalize to unseen cases with more diverse localized soft-tissue deformations. We propose a new anatomy-informed transformation that leverages information from adjacent organs to simulate typical physiological deformations of the prostate and generates unique lesion shapes without altering their label. Due to its lightweight computational requirements, it can be easily integrated into common DA frameworks. We demonstrate the effectiveness of our augmentation on a dataset of 774 biopsy-confirmed examinations, by evaluating a state-of-the-art method for PCa detection with different augmentation settings.

Desktop-based virtual colonoscopy has been proven to be an asset in the identification of colon anomalies. The process is accurate, although time-consuming. The use of immersive interfaces for virtual colonoscopy is incipient and not yet understood. In this work, we present a new design exploring elements of the VR paradigm to make the immersive analysis more efficient while still effective. We also plan the conduction of experiments with experts to assess the multi-factor influences of coverage, duration, and diagnostic accuracy.

Engineers have developed a flexible robot that enters the rectum to 3D print living cells on damaged organs, eliminating the need for patients to'go under the knife.' The University of South Wales Sydney team designed the miniature robotic arm to directly deliver'bioink,' made of gelatin, collagen, human cells and other materials, onto the surface of internal organs and tissues. The proof-of-concept device, known as F3DB, features a highly maneuverable swivel head that'prints' the bioink, attached to the end of the arm, all of which can be controlled externally. The research team said that with further development, and potentially within five to seven years, the technology could be used by medical professionals to access hard-to-reach areas inside the body via small skin incisions or natural orifices. The lead researcher Dr Thanh Nho Do said in a statement: 'Existing 3D bioprinting techniques require biomaterials to be made outside the body and implanting that into a person would usually require large open-field open surgery which increases infection risks. 'Our flexible 3D bioprinter means biomaterials can be directly delivered into the target tissue or organs with a minimally invasive approach.'

It may look strange, but this robotic rectum could help doctors and nurses detect prostate cancer. The device, made up of a prosthetic buttocks and rectum with in-built robotic technology, is designed to recreate the feel of a rectum, to help medics learn how to perform a prostate examination. It will also provide doctors and nurses feedback on their examination technique. It may look slightly strange, but this robotic rectum could help doctors and nurses detect prostate cancer. The device, made up of a prosthetic buttocks and rectum with in-built robotic technology, is designed to recreate the feel of a rectum.