Data sets that are specified by a large number of features are currently outside the area of applicability for quantum machine learning algorithms. An immediate solution to this impasse is the application of dimensionality reduction methods before passing the data to the quantum algorithm. We investigate six conventional feature extraction algorithms and five autoencoder-based dimensionality reduction models to a particle physics data set with 67 features. The reduced representations generated by these models are then used to train a quantum support vector machine for solving a binary classification problem: whether a Higgs boson is produced in proton collisions at the LHC. We show that the autoencoder methods learn a better lower-dimensional representation of the data, with the method we design, the Sinkclass autoencoder, performing 40% better than the baseline. The methods developed here open up the applicability of quantum machine learning to a larger array of data sets. Moreover, we provide a recipe for effective dimensionality reduction in this context.

Quantum Support Vector Machines face scalability challenges due to high-dimensional quantum states and hardware limitations. We propose an embedding-aware quantum-classical pipeline combining class-balanced k-means distillation with pretrained Vision Transformer embeddings. Our key finding: ViT embeddings uniquely enable quantum advantage, achieving up to 8.02% accuracy improvements over classical SVMs on Fashion-MNIST and 4.42% on MNIST, while CNN features show performance degradation. Using 16-qubit tensor network simulation via cuTensorNet, we provide the first systematic evidence that quantum kernel advantage depends critically on embedding choice, revealing fundamental synergy between transformer attention and quantum feature spaces. This provides a practical pathway for scalable quantum machine learning that leverages modern neural architectures.

Recently, there has been growing attention on combining quantum machine learning (QML) with classical deep learning approaches, as computational techniques are key to improving the performance of image classification tasks. This study presents a hybrid approach that uses ResNet-50 (Residual Network) for feature extraction and Quantum Support Vector Machines (QSVM) for classification in the context of potato disease detection. Classical machine learning as well as deep learning models often struggle with high-dimensional and complex datasets, necessitating advanced techniques like quantum computing to improve classification efficiency. In our research, we use ResNet-50 to extract deep feature representations from RGB images of potato diseases. These features are then subjected to dimensionality reduction using Principal Component Analysis (PCA). The resulting features are processed through QSVM models which apply various quantum feature maps such as ZZ, Z, and Pauli-X to transform classical data into quantum states. To assess the model performance, we compared it with classical machine learning algorithms such as Support Vector Machine (SVM) and Random Forest (RF) using five-fold stratified cross-validation for comprehensive evaluation. The experimental results demonstrate that the Z-feature map-based QSVM outperforms classical models, achieving an accuracy of 99.23 percent, surpassing both SVM and RF models. This research highlights the advantages of integrating quantum computing into image classification and provides a potential disease detection solution through hybrid quantum-classical modeling.

Current quantum computers require algorithms that use limited resources economically. In quantum machine learning, success hinges on quantum feature maps, which embed classical data into the state space of qubits. We introduce Quantum Feature-Map Learning via Analytic Iterative Reconstructions (Q-FLAIR), an algorithm that reduces quantum resource overhead in iterative feature-map circuit construction. It shifts workloads to a classical computer via partial analytic reconstructions of the quantum model, using only a few evaluations. For each probed gate addition to the ansatz, the simultaneous selection and optimization of the data feature and weight parameter is then entirely classical. Integrated into quantum neural network and quantum kernel support vector classifiers, Q-FLAIR shows state-of-the-art benchmark performance. Since resource overhead decouples from feature dimension, we train a quantum model on a real IBM device in only four hours, surpassing 90% accuracy on the full-resolution MNIST dataset (784 features, digits 3 vs 5). Such results were previously unattainable, as the feature dimension prohibitively drives hardware demands for fixed and search costs for adaptive ansätze. By rethinking feature-map learning beyond black-box optimization, this work takes a concrete step toward enabling quantum machine learning for real-world problems and near-term quantum computers.

Abstract--Quantum computing has opened new opportunities to tackle complex machine learning tasks, for instance, high-dimensional data representations commonly required in intelligent transportation systems. We explore quantum machine learning to model complex skin conductance response (SCR) events that reflect pedestrian stress in a virtual reality road crossing experiment. For this purpose, Quantum Support V ector Machine (QSVM) with an eight-qubit ZZ feature map and a Quantum Neural Network (QNN) using a Tree T ensor Network ansatz and an eight-qubit ZZ feature map, were developed on Pennylane. The dataset consists of SCR measurements along with features such as the response amplitude and elapsed time, which have been categorized into amplitude-based classes. The QSVM achieved good training accuracy, but had an overfitting problem, showing a low test accuracy of 45% and therefore impacting the reliability of the classification model. The QNN model reached a higher test accuracy of 55%, making it a better classification model than the QSVM and the classic versions.

In recent years, quantum machine learning has emerged as a promising intersection between quantum physics and artificial intelligence, particularly in domains requiring advanced pattern recognition such as healthcare. This study investigates the effectiveness of Quantum Support Vector Machines (QSVM), which leverage quantum mechanical phenomena like superposition and entanglement to construct high-dimensional Hilbert spaces for data classification. Focusing on lung cancer diagnosis, a concrete and critical healthcare application, we analyze how different quantum feature maps influence classification performance. Using a real-world dataset of 309 patient records with significant class imbalance (39 non-cancer vs. 270 cancer cases), we constructed six balanced subsets for robust evaluation. QSVM models were implemented using Qiskit and executed on the qasm simulator, employing three distinct quantum feature maps: ZFeatureMap, ZZFeatureMap, and PauliFeatureMap. Performance was assessed using accuracy, precision, recall, specificity, and F1-score. Results show that the PauliFeatureMap consistently outperformed the others, achieving perfect classification in three subsets and strong performance overall. These findings demonstrate how quantum computational principles can be harnessed to enhance diagnostic capabilities, reinforcing the importance of physics-based modeling in emerging AI applications within healthcare.

A brain-computer interface (BCI) system enables direct communication between the brain and external devices, offering significant potential for assistive technologies and advanced human-computer interaction. Despite progress, BCI systems face persistent challenges, including signal variability, classification inefficiency, and difficulty adapting to individual users in real time. In this study, we propose a novel hybrid quantum learning model, termed QSVM-QNN, which integrates a Quantum Support Vector Machine (QSVM) with a Quantum Neural Network (QNN), to improve classification accuracy and robustness in EEG-based BCI tasks. Unlike existing models, QSVM-QNN combines the decision boundary capabilities of QSVM with the expressive learning power of QNN, leading to superior generalization performance. The proposed model is evaluated on two benchmark EEG datasets, achieving high accuracies of 0.990 and 0.950, outperforming both classical and standalone quantum models. To demonstrate real-world viability, we further validated the robustness of QNN, QSVM, and QSVM-QNN against six realistic quantum noise models, including bit flip and phase damping. These experiments reveal that QSVM-QNN maintains stable performance under noisy conditions, establishing its applicability for deployment in practical, noisy quantum environments. Beyond BCI, the proposed hybrid quantum architecture is generalizable to other biomedical and time-series classification tasks, offering a scalable and noise-resilient solution for next-generation neurotechnological systems.

The unprecedented global COVID - 19 pandemic has prompted researchers to investigate both the biochemical changes associated with acute infection and the long - term effects of COVID - 19, with the goal of elucidating underlying mechanisms [ 1 4 ]. Among the diverse biochemical alterations observed in COVID - 19, change s in metabolomic and proteomic profiles have drawn particular attention due to their roles in fundamental biological processes, including protein expression and metabolic pathways [5, 6]. Early in the pandemic, several studies highlighted the significance of certain biomarkers for diagnosing COVID - 19 and assessing disease severity [7, 8]. These initial finding s reveal ed that specific biomarkers are involved in COVID - 19 pathogenesis and correlate with disease severity. S ubsequent research into post - acute sequelae of COVID - 19 (PASC, or long COVID) has further shown that variations in these biomarkers are associated with neurological and respiratory complications [9, 10]. Collectively, these studie s highlight the importance of identifying key biomarkers to support both acute COVID - 19 detection and the understanding of long COVID.

Quantum computing holds significant potential to accelerate machine learning algorithms, especially in solving optimization problems like those encountered in Support Vector Machine (SVM) training. However, current QUBO-based Quantum SVM (QSVM) methods rely solely on binary optimal solutions, limiting their ability to identify fuzzy boundaries in data. Additionally, the limited qubit count in contemporary quantum devices constrains training on larger datasets. In this paper, we propose a probabilistic quantum SVM training framework suitable for Coherent Ising Machines (CIMs). By formulating the SVM training problem as a QUBO model, we leverage CIMs' energy minimization capabilities and introduce a Boltzmann distribution-based probabilistic approach to better approximate optimal SVM solutions, enhancing robustness. To address qubit limitations, we employ batch processing and multi-batch ensemble strategies, enabling small-scale quantum devices to train SVMs on larger datasets and support multi-class classification tasks via a one-vs-one approach. Our method is validated through simulations and real-machine experiments on binary and multi-class datasets. On the banknote binary classification dataset, our CIM-based QSVM, utilizing an energy-based probabilistic approach, achieved up to 20% higher accuracy compared to the original QSVM, while training up to $10^4$ times faster than simulated annealing methods. Compared with classical SVM, our approach either matched or reduced training time. On the IRIS three-class dataset, our improved QSVM outperformed existing QSVM models in all key metrics. As quantum technology advances, increased qubit counts are expected to further enhance QSVM performance relative to classical SVM.

In this study, we use cross-domain classification using quantum machine learning for quantum advantages to address the entanglement versus separability paradigm. We further demonstrate the efficient classification of Bell diagonal states into zero and non-zero discord classes. The inherited structure of quantum states and its relation with a particular class of quantum states are exploited to intuitively approach the classification of different domain testing states, referred here as crossdomain classification. In addition, we extend our analysis to evaluate the robustness of our model for the analyzed problem using random unitary transformations. Using numerical analysis, our results clearly demonstrate the potential of QSVM for classifying quantum states across the multidimensional Hilbert space.