Can large language models (LLMs) instantiate computations of psychopathology? An effective approach to the question hinges on addressing two factors. First, for conceptual validity, we require a general and computational account of psychopathology that is applicable to computational entities without biological embodiment or subjective experience. Second, psychopathological computations, derived from the adapted theory, need to be empirically identified within the LLM's internal processing. Thus, we establish a computational-theoretical framework to provide an account of psychopathology applicable to LLMs. Based on the framework, we conduct experiments demonstrating two key claims: first, that the computational structure of psychopathology exists in LLMs; and second, that executing this computational structure results in psychopathological functions. We further observe that as LLM size increases, the computational structure of psychopathology becomes denser and that the functions become more effective. Taken together, the empirical results corroborate our hypothesis that network-theoretic computations of psychopathology have already emerged in LLMs. This suggests that certain LLM behaviors mirroring psychopathology may not be a superficial mimicry but a feature of their internal processing. Our work shows the promise of developing a new powerful in silico model of psychopathology and also alludes to the possibility of safety threat from the AI systems with psychopathological behaviors in the near future.

It might sound like a scenario from the most far-fetched of science fiction novels. But scientists have revealed the 32 terrifyingly real ways that AI systems could go rogue. Researchers warn that sufficiently advanced AI might start to develop'behavioural abnormalities' which mirror human psychopathologies. From relatively harmless'Existential Anxiety' to the potentially catastrophic 'Übermenschal Ascendancy', any of these machine mental illnesses could lead to AI escaping human control. As AI systems become more complex and gain the ability to reflect on themselves, scientists are concerned that their errors may go far beyond simple computer bugs.

This study integrates causal inference, graph analysis, temporal complexity measures, and machine learning to examine whether individual symptom trajectories can reveal meaningful diagnostic patterns. Testing on a longitudinal dataset of N=45 individuals affected by General Anxiety Disorder (GAD) and/or Major Depressive Disorder (MDD) derived from Fisher et al. 2017, we propose a novel pipeline for the analysis of the temporal dynamics of psychopathological symptoms. First, we employ the PCMCI+ algorithm with nonparametric independence test to determine the causal network of nonlinear dependencies between symptoms in individuals with different mental disorders. We found that the PCMCI+ effectively highlights the individual peculiarities of each symptom network, which could be leveraged towards personalized therapies. At the same time, aggregating the networks by diagnosis sheds light to disorder-specific causal mechanisms, in agreement with previous psychopathological literature. Then, we enrich the dataset by computing complexity-based measures (e.g. entropy, fractal dimension, recurrence) from the symptom time series, and feed it to a suitably selected machine learning algorithm to aid the diagnosis of each individual. The new dataset yields 91% accuracy in the classification of the symptom dynamics, proving to be an effective diagnostic support tool. Overall, these findings highlight how integrating causal modeling and temporal complexity can enhance diagnostic differentiation, offering a principled, data-driven foundation for both personalized assessment in clinical psychology and structural advances in psychological research.

Computational mental health research develops models to predict and understand psychological phenomena, but often relies on inappropriate measures of psychopathology constructs, undermining validity. We identify three key issues: (1) reliance on unvalidated measures (e.g., self-declared diagnosis) over validated ones (e.g., diagnosis by clinician); (2) treating mental health constructs as categorical rather than dimensional; and (3) focusing on disorder-specific constructs instead of transdiagnostic ones. We outline the benefits of using validated, dimensional, and transdiagnostic measures and offer practical recommendations for practitioners. Using valid measures that reflect the nature and structure of psychopathology is essential for computational mental health research.

In the field of psychopathology, Ecological Momentary Assessment (EMA) studies offer rich individual data on psychopathology-relevant variables (e.g., affect, behavior, etc) in real-time. EMA data is collected dynamically, represented as complex multivariate time series (MTS). Such information is crucial for a better understanding of mental disorders at the individual- and group-level. More specifically, clustering individuals in EMA data facilitates uncovering and studying the commonalities as well as variations of groups in the population. Nevertheless, since clustering is an unsupervised task and true EMA grouping is not commonly available, the evaluation of clustering is quite challenging. An important aspect of evaluation is clustering explainability. Thus, this paper proposes an attention-based interpretable framework to identify the important time-points and variables that play primary roles in distinguishing between clusters. A key part of this study is to examine ways to analyze, summarize, and interpret the attention weights as well as evaluate the patterns underlying the important segments of the data that differentiate across clusters. To evaluate the proposed approach, an EMA dataset of 187 individuals grouped in 3 clusters is used for analyzing the derived attention-based importance attributes. More specifically, this analysis provides the distinct characteristics at the cluster-, feature- and individual level. Such clustering explanations could be beneficial for generalizing existing concepts of mental disorders, discovering new insights, and even enhancing our knowledge at an individual level.

In the evolving field of psychopathology, the accurate assessment and forecasting of data derived from Ecological Momentary Assessment (EMA) is crucial. EMA offers contextually-rich psychopathological measurements over time, that practically lead to Multivariate Time Series (MTS) data. Thus, many challenges arise in analysis from the temporal complexities inherent in emotional, behavioral, and contextual EMA data as well as their inter-dependencies. To address both of these aspects, this research investigates the performance of Recurrent and Temporal Graph Neural Networks (GNNs). Overall, GNNs, by incorporating additional information from graphs reflecting the inner relationships between the variables, notably enhance the results by decreasing the Mean Squared Error (MSE) to 0.84 compared to the baseline LSTM model at 1.02. Therefore, the effect of constructing graphs with different characteristics on GNN performance is also explored. Additionally, GNN-learned graphs, which are dynamically refined during the training process, were evaluated. Using such graphs showed a similarly good performance. Thus, graph learning proved also promising for other GNN methods, potentially refining the pre-defined graphs.

Generative AI models garnered a large amount of public attention and speculation with the release of OpenAIs chatbot, ChatGPT. At least two opinion camps exist: one excited about possibilities these models offer for fundamental changes to human tasks, and another highly concerned about power these models seem to have. To address these concerns, we assessed several LLMs, primarily GPT 3.5, using standard, normed, and validated cognitive and personality measures. For this seedling project, we developed a battery of tests that allowed us to estimate the boundaries of some of these models capabilities, how stable those capabilities are over a short period of time, and how they compare to humans. Our results indicate that LLMs are unlikely to have developed sentience, although its ability to respond to personality inventories is interesting. GPT3.5 did display large variability in both cognitive and personality measures over repeated observations, which is not expected if it had a human-like personality. Variability notwithstanding, LLMs display what in a human would be considered poor mental health, including low self-esteem, marked dissociation from reality, and in some cases narcissism and psychopathy, despite upbeat and helpful responses.

Research in psychopathology has shown that, at an aggregate level, the patterns of emotional change over time -- emotion dynamics -- are indicators of one's mental health. One's patterns of emotion change have traditionally been determined through self-reports of emotions; however, there are known issues with accuracy, bias, and ease of data collection. Recent approaches to determining emotion dynamics from one's everyday utterances addresses many of these concerns, but it is not yet known whether these measures of utterance emotion dynamics (UED) correlate with mental health diagnoses. Here, for the first time, we study the relationship between tweet emotion dynamics and mental health disorders. We find that each of the UED metrics studied varied by the user's self-disclosed diagnosis. For example: average valence was significantly higher (i.e., more positive text) in the control group compared to users with ADHD, MDD, and PTSD. Valence variability was significantly lower in the control group compared to ADHD, depression, bipolar disorder, MDD, PTSD, and OCD but not PPD. Rise and recovery rates of valence also exhibited significant differences from the control. This work provides important early evidence for how linguistic cues pertaining to emotion dynamics can play a crucial role as biosocial markers for mental illnesses and aid in the understanding, diagnosis, and management of mental health disorders.

In the field of psychopathology, Ecological Momentary Assessment (EMA) methodological advancements have offered new opportunities to collect time-intensive, repeated and intra-individual measurements. This way, a large amount of data has become available, providing the means for further exploring mental disorders. Consequently, advanced machine learning (ML) methods are needed to understand data characteristics and uncover hidden and meaningful relationships regarding the underlying complex psychological processes. Among other uses, ML facilitates the identification of similar patterns in data of different individuals through clustering. This paper focuses on clustering multivariate time-series (MTS) data of individuals into several groups. Since clustering is an unsupervised problem, it is challenging to assess whether the resulting grouping is successful. Thus, we investigate different clustering methods based on different distance measures and assess them for the stability and quality of the derived clusters. These clustering steps are illustrated on a real-world EMA dataset, including 33 individuals and 15 variables. Through evaluation, the results of kernel-based clustering methods appear promising to identify meaningful groups in the data. So, efficient representations of EMA data play an important role in clustering.

COVID-19 pandemic has profoundly influenced the health, financial, and social texture of countries. Recognizable proof of individual-level susceptibility factors may help individuals in distinguishing and dealing with their emotional, psychological, and social well-being. In March 2020, the episode of the Covid illness 2019 (COVID-19) arrived in all nations of the Western world. To decrease the speed of its spread, numerous nations hindered their economies and upheld articulated limitations on public life. After calamities, the vast majority are resilient and don't surrender to psychopathology.