Vision-Language Models (VLMs) are foundational to critical applications like autonomous driving, medical diagnosis, and content moderation. While Parameter-Efficient Fine-Tuning (PEFT) methods like LoRA enable their efficient adaptation to specialized tasks, these models remain vulnerable to adversarial attacks that can compromise safety-critical decisions. CLIP, the backbone for numerous downstream VLMs, is a high-value target whose vulnerabilities can cascade across the multimodal AI ecosystem. We propose Dynamic Adversarial Curriculum DAC-LoRA, a novel framework that integrates adversarial training into PEFT. The core principle of our method i.e. an intelligent curriculum of progressively challenging attack, is general and can potentially be applied to any iterative attack method. Guided by the First-Order Stationary Condition (FOSC) and a TRADES-inspired loss, DAC-LoRA achieves substantial improvements in adversarial robustness without significantly compromising clean accuracy. Our work presents an effective, lightweight, and broadly applicable method to demonstrate that the DAC-LoRA framework can be easily integrated into a standard PEFT pipeline to significantly enhance robustness.

Target-specific peptides, such as conotoxins, exhibit exceptional binding affinity and selectivity toward ion channels and receptors. However, their therapeutic potential remains underutilized due to the limited diversity of natural variants and the labor-intensive nature of traditional optimization strategies. Here, we present CreoPep, a deep learning-based conditional generative framework that integrates masked language modeling with a progressive masking scheme to design high-affinity peptide mutants while uncovering novel structural motifs. CreoPep employs an integrative augmentation pipeline, combining FoldX-based energy screening with temperature-controlled multinomial sampling, to generate structurally and functionally diverse peptides that retain key pharmacological properties. We validate this approach by designing conotoxin inhibitors targeting the $α$7 nicotinic acetylcholine receptor, achieving submicromolar potency in electrophysiological assays. Structural analysis reveals that CreoPep-generated variants engage in both conserved and novel binding modes, including disulfide-deficient forms, thus expanding beyond conventional design paradigms. Overall, CreoPep offers a robust and generalizable platform that bridges computational peptide design with experimental validation, accelerating the discovery of next-generation peptide therapeutics.

We introduce a novel non-cooperative game to analyse opinion formation and resistance, incorporating principles from social psychology such as confirmation bias, resource constraints, and influence penalties. Our simulation features Large Language Model (LLM) agents competing to influence a population, with penalties imposed for generating messages that propagate or counter misinformation. This framework integrates resource optimisation into the agents' decision-making process. Our findings demonstrate that while higher confirmation bias strengthens opinion alignment within groups, it also exacerbates overall polarisation. Conversely, lower confirmation bias leads to fragmented opinions and limited shifts in individual beliefs. Investing heavily in a high-resource debunking strategy can initially align the population with the debunking agent, but risks rapid resource depletion and diminished long-term influence.

Health issues and pandemics remain paramount concerns in the contemporary era. Clostridioides Difficile Infection (CDI) stands out as a critical healthcare-associated infection with global implications. Effectively understanding the mechanisms of infection dissemination within healthcare units and hospitals is imperative to implement targeted containment measures. In this study, we address the limitations of prior research by Sulyok et al., where they delineated two distinct categories of surfaces as high-touch and low-touch fomites, and subsequently evaluated the viral spread contribution of each surface utilizing mathematical modeling and Ordinary Differential Equations (ODE). Acknowledging the indispensable role of spatial features and heterogeneity in the modeling of hospital and healthcare settings, we employ agent-based modeling to capture new insights. By incorporating spatial considerations and heterogeneous patients, we explore the impact of high-touch and low-touch surfaces on contamination transmission between patients. Furthermore, the study encompasses a comprehensive assessment of various cleaning protocols, with differing intervals and detergent cleaning efficacies, in order to identify the most optimal cleaning strategy and the most important factor amidst the array of alternatives. Our results indicate that, among various factors, the frequency of cleaning intervals is the most critical element for controlling the spread of CDI in a hospital environment.

The pharmaceutical Research and development (R&D) process is lengthy and costly, taking nearly a decade to bring a new drug to the market. However, advancements in biotechnology, computational methods, and machine learning algorithms have the potential to revolutionize drug discovery, speeding up the process and improving patient outcomes. The COVID-19 pandemic has further accelerated and deepened the recognition of the potential of these techniques, especially in the areas of drug repurposing and efficacy predictions. Meanwhile, non-small molecule therapeutic modalities such as cell therapies, monoclonal antibodies, and RNA interference (RNAi) technology have gained importance due to their ability to target specific disease pathways and/or patient populations. In the field of RNAi, many experiments have been carried out to design and select highly efficient siRNAs. However, the established patterns for efficient siRNAs are sometimes contradictory and unable to consistently determine the most potent siRNA molecules against a target mRNA. Thus, this paper focuses on developing machine learning models based on the cheminformatics representation of the nucleotide composition (i.e. AUTGC) of siRNA to predict their potency and aid the selection of the most efficient siRNAs for further development. The PLS (Partial Least Square) and SVR (Support Vector Regression) machine learning models built in this work outperformed previously published models. These models can help in predicting siRNA potency and aid in selecting the best siRNA molecules for experimental validation and further clinical development. The study has demonstrated the potential of AI/machine learning models to help expedite siRNA-based drug discovery including the discovery of potent siRNAs against SARS-CoV-2.

As Federated Learning (FL) grows in popularity, new decentralized frameworks are becoming widespread. These frameworks leverage the benefits of decentralized environments to enable fast and energy-efficient inter-device communication. However, this growing popularity also intensifies the need for robust security measures. While existing research has explored various aspects of FL security, the role of adversarial node placement in decentralized networks remains largely unexplored. This paper addresses this gap by analyzing the performance of decentralized FL for various adversarial placement strategies when adversaries can jointly coordinate their placement within a network. We establish two baseline strategies for placing adversarial node: random placement and network centrality-based placement. Building on this foundation, we propose a novel attack algorithm that prioritizes adversarial spread over adversarial centrality by maximizing the average network distance between adversaries. We show that the new attack algorithm significantly impacts key performance metrics such as testing accuracy, outperforming the baseline frameworks by between 9% and 66.5% for the considered setups. Our findings provide valuable insights into the vulnerabilities of decentralized FL systems, setting the stage for future research aimed at developing more secure and robust decentralized FL frameworks.

Extensive bedside monitoring in Intensive Care Units (ICUs) has resulted in complex temporal data regarding patient physiology, which presents an upscale context for clinical data analysis. In the other hand, identifying the time-series patterns within these data may provide a high aptitude to predict clinical events. Hence, we investigate, during this work, the implementation of an automatic data-driven system, which analyzes large amounts of multivariate temporal data derived from Electronic Health Records (EHRs), and extracts high-level information so as to predict in-hospital mortality and Length of Stay (LOS) early. Practically, we investigate the applicability of LSTM network by reducing the time-frame to 6-hour so as to enhance clinical tasks. The experimental results highlight the efficiency of LSTM model with rigorous multivariate time-series measurements for building real-world prediction engines.

Artificial intelligence (AI) could be a quickly growing field that has the potential to revolutionize several aspects of our lives. At its most elementary, AI is that the ability of a machine or ADP system to perform tasks that will commonly need human intelligence, like recognizing patterns, learning from knowledge, and problem-solving. AI are often classified into 2 broad categories: slender AI and general AI. Narrow AI, additionally referred to as weak AI, is meant to perform a particular task or set of tasks. These systems area unit programmed to perform specific tasks; however, they are doing not have the flexibility to find out or adapt to new things.

Tomorrow I'm speaking in a webinar hosted by the King Abdulaziz University - University of Oxford Centre For Artificial Intelligence in Precision Medicines (CAIPM). CAIPM is a leading global innovation center for developing precise therapies using AI and emerging technologies. The Center is a strategic partnership between King Abdulaziz University in The Kingdom of Saudi Arabia and the University of Oxford. CAIPM provides a multidisciplinary hub for building research leadership with a high-impact and sustainable value to provide potential therapeutic solutions to patients around the world. The CAIPM was founded based on Saudi Vision 2030 to improve quality of life which includes promoting health and providing innovative treatment solutions for various intractable diseases for which there are no current treatments.

The global insurance market is experiencing a metamorphosis to'digital-first' business models that may unlock new worth value billions of greenbacks Collaboration between ancient insurance and InsurTech companies can bring about to newer models and revenue streams, higher profitableness and reduced operational price. Artificial Intelligence (AI) plays a vital role in reworking the insurance business. Today, with the increasing quality of wearable devices, IoT, and sensible mobile apps, insurance organizations ar capable of optimizing advanced insurance selections and investigations. Intelligent tools and applications utilized by the insurance shoppers change insurance suppliers to access the dear data of their customers' health and provide custom-made insurance policies. In recent years, AI-based tending tools and applications have speedily optimized and hyperbolic the potency of insurance organizations across the world.