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This paper presents the Photonic FabricTM and the Photonic Fabric ApplianceTM (PFA), a photonic-enabled switch and memory subsystem that delivers low latency, high bandwidth, and low per-bit energy. By integrating high-bandwidth HBM3E memory, an on-module photonic switch, and external DDR5 in a 2.5D electro-optical system-in-package, the PFA offers up to 32 TB of shared memory alongside 115 Tbps of all-to-all digital switching. The Photonic FabricTM enables distributed AI training and inference to execute parallelism strategies more efficiently. The Photonic Fabric removes the silicon beachfront constraint that limits the fixed memory-to-compute ratio observed in virtually all current XPU accelerator designs. Replacing a local HBM stack on an XPU with a chiplet that connects to the Photonic Fabric increases its memory capacity and correspondingly its memory bandwidth by offering a flexible path to scaling well beyond the limitations of on-package HBM alone. We introduce CelestiSim, a lightweight analytical simulator validated on NVIDIA H100 and H200 systems. It is used to evaluate the performance of LLM reference and energy savings on PFA, without any significant change to the GPU core design. With the PFA, the simulation results show that up to 3.66x throughput and 1.40x latency improvements in LLM inference at 405B parameters, up to 7.04x throughput and 1.41x latency improvements at 1T parameters, and 60-90% energy savings in data movement for heavy collective operations in all LLM training scenarios. While these results are shown for NVIDIA GPUs, they can be applied similarly to other AI accelerator designs (XPUs) that share the same fundamental limitation of fixed memory to compute.

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants with known toxicity and bioaccumulation issues. Their widespread industrial use and resistance to degradation have led to global environmental contamination and significant health concerns. While a minority of PFAS have been extensively studied, the toxicity of many PFAS remains poorly understood due to limited direct toxicological data. This study advances the predictive modeling of PFAS toxicity by combining semi-supervised graph convolutional networks (GCNs) with molecular descriptors and fingerprints. We propose a novel approach to enhance the prediction of PFAS binding affinities by isolating molecular fingerprints to construct graphs where then descriptors are set as the node features. This approach specifically captures the structural, physicochemical, and topological features of PFAS without overfitting due to an abundance of features. Unsupervised clustering then identifies representative compounds for detailed binding studies. Our results provide a more accurate ability to estimate PFAS hepatotoxicity to provide guidance in chemical discovery of new PFAS and the development of new safety regulations.

The attention mechanism has been proven to be an effective way to improve spiking neural network (SNN). However, based on the fact that the current SNN input data flow is split into tensors to process on GPUs, none of the previous works consider the properties of tensors to implement an attention module. This inspires us to rethink current SNN from the perspective of tensor-relevant theories. Using tensor decomposition, we design the \textit{projected full attention} (PFA) module, which demonstrates excellent results with linearly growing parameters. Specifically, PFA is composed by the \textit{linear projection of spike tensor} (LPST) module and \textit{attention map composing} (AMC) module. In LPST, we start by compressing the original spike tensor into three projected tensors using a single property-preserving strategy with learnable parameters for each dimension. Then, in AMC, we exploit the inverse procedure of the tensor decomposition process to combine the three tensors into the attention map using a so-called connecting factor. To validate the effectiveness of the proposed PFA module, we integrate it into the widely used VGG and ResNet architectures for classification tasks. Our method achieves state-of-the-art performance on both static and dynamic benchmark datasets, surpassing the existing SNN models with Transformer-based and CNN-based backbones.

In statistics, the least absolute shrinkage and selection operator (Lasso) is a regression method that performs both variable selection and regularization. There is a lot of literature available, discussing the statistical properties of the regression coefficients estimated by the Lasso method. However, there lacks a comprehensive review discussing the algorithms to solve the optimization problem in Lasso. In this review, we summarize five representative algorithms to optimize the objective function in Lasso, including the iterative shrinkage threshold algorithm (ISTA), fast iterative shrinkage-thresholding algorithms (FISTA), coordinate gradient descent algorithm (CGDA), smooth L1 algorithm (SLA), and path following algorithm (PFA). Additionally, we also compare their convergence rate, as well as their potential strengths and weakness.

Despite their large numbers and widespread use, very little is known about the extent to which per- and polyfluoroalkyl substances (PFAS) can cross the placenta and expose the developing fetus. The aim of our study is to develop a computational approach that can be used to evaluate the of extend to which small molecules, and in particular PFAS, can cross to cross the placenta and partition to cord blood. We collected experimental values of the concentration ratio between cord and maternal blood (RCM) for 260 chemical compounds and calculated their physicochemical descriptors using the cheminformatics package Mordred. We used the compiled database to, train and test an artificial neural network (ANN). And then applied the best performing model to predict RCM for a large dataset of PFAS chemicals (n = 7982). We, finally, examined the calculated physicochemical descriptors of the chemicals to identify which properties correlated significantly with RCM. We determined that 7855 compounds were within the applicability domain and 127 compounds are outside the applicability domain of our model. Our predictions of RCM for PFAS suggested that 3623 compounds had a log RCM > 0 indicating preferable partitioning to cord blood. Some examples of these compounds were bisphenol AF, 2,2-bis(4-aminophenyl)hexafluoropropane, and nonafluoro-tert-butyl 3-methylbutyrate. These observations have important public health implications as many PFAS have been shown to interfere with fetal development. In addition, as these compounds are highly persistent and many of them can readily cross the placenta, they are expected to remain in the population for a long time as they are being passed from parent to offspring. Understanding the behavior of chemicals in the human body during pregnancy is critical in preventing harmful exposures during critical periods of development. Many chemicals can cross the placenta and expose the fetus, however, the mechanism by which this transport occurs is not well understood. In our study, we developed a machine learning model that describes the transplacental transfer of chemicals as a function of their physicochemical properties. The model was then used to make predictions for a set of 7982 per- and polyfluorinated alkyl substances that are listed on EPA’s CompTox Chemicals Dashboard. The model can be applied to make predictions for other chemical categories of interest, such as plasticizers and pesticides. Accurate predictions of RCM can help scientists and regulators to prioritize chemicals that have the potential to cause harm by exposing the fetus.

A journalist who covers wildfires responds to Premee Mohamed's "All That Burns Unseen." In "All That Burns Unseen," set in a dystopian but not-too-distant future, we finally get the drone sidekick we didn't know we needed. Premee Mohamed's heroine, Vaughn Collins, is a government worker gone rogue as a wildfire burns. Along the way, she rescues a dazed, glitchy fire extinguisher drone. When a funnel of flames heads for Vaughn's truck, threatening everything, her new friend dives into the blaze and sprays.

Federated learning (FL) has become a prevalent distributed machine learning paradigm with improved privacy. After learning, the resulting federated model should be further personalized to each different client. While several methods have been proposed to achieve personalization, they are typically limited to a single local device, which may incur bias or overfitting since data in a single device is extremely limited. In this paper, we attempt to realize personalization beyond a single client. The motivation is that during FL, there may exist many clients with similar data distribution, and thus the personalization performance could be significantly boosted if these similar clients can cooperate with each other. Inspired by this, this paper introduces a new concept called federated adaptation, targeting at adapting the trained model in a federated manner to achieve better personalization results. However, the key challenge for federated adaptation is that we could not outsource any raw data from the client during adaptation, due to privacy concerns. In this paper, we propose PFA, a framework to accomplish Privacy-preserving Federated Adaptation. PFA leverages the sparsity property of neural networks to generate privacy-preserving representations and uses them to efficiently identify clients with similar data distributions. Based on the grouping results, PFA conducts an FL process in a group-wise way on the federated model to accomplish the adaptation. For evaluation, we manually construct several practical FL datasets based on public datasets in order to simulate both the class-imbalance and background-difference conditions. Extensive experiments on these datasets and popular model architectures demonstrate the effectiveness of PFA, outperforming other state-of-the-art methods by a large margin while ensuring user privacy. We will release our code at: https://github.com/lebyni/PFA.

We can think of the number of states of the automaton as a proxy for how computationally bounded the While traditional economics assumes that humans agent is. Neyman (1985) showed that cooperation can are fully rational agents who always arise if PFAs play a finitely-repeated prisoner's dilemma; maximize their expected utility, in practice, we work on this topic has continued to attract attention (see constantly observe apparently irrational behavior. Papadimitriou and Yannakakis (1994) and the references One explanation is that people have limited therein). Wilson (2015) considered a decision problem computational power, so that they are, quite rationally, where an agent must decide whether nature is in state 0 making the best decisions they can, or state 1, after getting signals that are correlated with given their computational limitations.

The need of interpreting Deep Learning (DL) models has led, during the past years, to a proliferation of works concerned by this issue. Among strategies which aim at shedding some light on how information is represented internally in DL models, one consists in extracting symbolic rule-based machines from connectionist models that are supposed to approximate well their behaviour. In order to better understand how reasonable these approximation strategies are, we need to know the computational complexity of measuring the quality of approximation. In this article, we will prove some computational results related to the problem of extracting Finite State Machine (FSM) based models from trained RNN Language models. More precisely, we'll show the following: (a) For general weighted RNN-LMs with a single hidden layer and a ReLu activation: - The equivalence problem of a PDFA/PFA/WFA and a weighted first-order RNN-LM is undecidable; - As a corollary, the distance problem between languages generated by PDFA/PFA/WFA and that of a weighted RNN-LM is not recursive; -The intersection between a DFA and the cut language of a weighted RNN-LM is undecidable; - The equivalence of a PDFA/PFA/WFA and weighted RNN-LM in a finite support is EXP-Hard; (b) For consistent weight RNN-LMs with any computable activation function: - The Tcheybechev distance approximation is decidable; - The Tcheybechev distance approximation in a finite support is NP-Hard. Moreover, our reduction technique from 3-SAT makes this latter fact easily generalizable to other RNN architectures (e.g. LSTMs/RNNs), and RNNs with finite precision.