Multi-modal learning is essential for understanding information in the real world. Jointly learning from multi-modal data enables global integration of both shared and modality-specific information, but current strategies often fail when observations from certain modalities are incomplete or missing for part of the subjects. To learn comprehensive representations based on such modality-incomplete data, we present a semi-supervised neural network model called CLUE (Cross-Linked Unified Embedding). Extending from multi-modal VAEs, CLUE introduces the use of cross-encoders to construct latent representations from modality-incomplete observations. Representation learning for modality-incomplete observations is common in genomics. For example, human cells are tightly regulated across multiple related but distinct modalities such as DNA, RNA, and protein, jointly defining a cell's function. We benchmark CLUE on multi-modal data from single cell measurements, illustrating CLUE's superior performance in all assessed categories of the NeurIPS 2021 Multimodal Single-cell Data Integration Competition. While we focus on analysis of single cell genomic datasets, we note that the proposed cross-linked embedding strategy could be readily applied to other cross-modality representation learning problems.

Video question answering (VideoQA) is a complex task that requires diverse multi-modal data for training. Manual annotation of question and answers for videos, however, is tedious and prohibits scalability. To tackle this problem, recent methods consider zero-shot settings with no manual annotation of visual question-answer. In particular, a promising approach adapts frozen autoregressive language models pretrained on Web-scale text-only data to multi-modal inputs. In contrast, we here build on frozen bidirectional language models (BiLM) and show that such an approach provides a stronger and cheaper alternative for zero-shot VideoQA. In particular, (i) we combine visual inputs with the frozen BiLM using light trainable modules, (ii) we train such modules using Web-scraped multi-modal data, and finally (iii) we perform zero-shot VideoQA inference through masked language modeling, where the masked text is the answer to a given question. Our proposed approach, FrozenBiLM, outperforms the state of the art in zero-shot VideoQA by a significant margin on a variety of datasets, including LSMDC-FiB, iVQA, MSRVTT-QA, MSVD-QA, ActivityNet-QA, TGIF-FrameQA, How2QA and TVQA. It also demonstrates competitive performance in the few-shot and fully-supervised setting. Our code and models are publicly available at https://github.com/antoyang/FrozenBiLM.

Abstract--Large models (LMs), such as ChatGPT, have made a significant impact across diverse domains and hold great potential to facilitate the evolution of network intelligence. Wireless-native multi-modal large models (WMLMs) can sense and understand the physical world through multi-modal data, serving as a key enabler that integrates communication, sensing, and intelligence, and thus they can boost various smart services to billions of users. However, research on WMLMs remains in its infancy, and the construction of domain-specific multi-modal large models for wireless networks is still underexplored. In this paper, we outlines the key characteristics of WMLMs and summarizes existing methods, on the basis of which a wireless-native multimodal training paradigm is proposed. Specifically, we constructed a GPT -style WMLM model and trained it on a real-world large-scale dataset, leveraging wireless signals as an anchor modality for contrastive learning. Our approach demonstrates outstanding performance compared with existing small-scale models and large multi-modal models, validating the feasibility of using wireless signals as a universal modality and highlighting WMLM's potential to emerge as a new paradigm for future wireless networks. The advent of large AI models (LMs) such as ChatGPT has propelled network intelligence into a new evolutionary phase. These remarkable enablers are poised to revolutionize future wireless networks through their advanced performance and generalization capability.

Multi-modal co-learning is emerging as an effective paradigm in machine learning, enabling models to collaboratively learn from different modalities to enhance single-modality predictions. Earth Observation (EO) represents a quintessential domain for multi-modal data analysis, wherein diverse remote sensors collect data to sense our planet. This unprecedented volume of data introduces novel challenges. Specifically, the access to the same sensor modalities at both training and inference stages becomes increasingly complex based on real-world constraints affecting remote sensing platforms. In this context, multi-modal co-learning presents a promising strategy to leverage the vast amount of sensor-derived data available at the training stage to improve single-modality models for inference-time deployment. Most current research efforts focus on designing customized solutions for either particular downstream tasks or specific modalities available at the inference stage. To address this, we propose a novel multi-modal co-learning framework capable of generalizing across various tasks without targeting a specific modality for inference. Our approach combines contrastive and modality discriminative learning together to guide single-modality models to structure the internal model manifold into modality-shared and modality-specific information. We evaluate our framework on four EO benchmarks spanning classification and regression tasks across different sensor modalities, where only one of the modalities available during training is accessible at inference time. Our results demonstrate consistent predictive improvements over state-of-the-art approaches from the recent machine learning and computer vision literature, as well as EO-specific methods. The obtained findings validate our framework in the single-modality inference scenarios across a diverse range of EO applications.

Drug-target interaction (DTI) prediction is of great significance for drug discovery and drug repurposing. With the accumulation of a large volume of valuable data, data-driven methods have been increasingly harnessed to predict DTIs, reducing costs across various dimensions. Therefore, this paper proposes a $\textbf{L}$arge $\textbf{L}$anguage $\textbf{M}$odel and $\textbf{M}$ulti-$\textbf{M}$odel data co-powered $\textbf{D}$rug $\textbf{T}$arget $\textbf{I}$nteraction prediction framework, named LLM$^3$-DTI. LLM$^3$-DTI constructs multi-modal data embedding to enhance DTI prediction performance. In this framework, the text semantic embeddings of drugs and targets are encoded by a domain-specific LLM. To effectively align and fuse multi-modal embedding. We propose the dual cross-attention mechanism and the TSFusion module. Finally, these multi-modal data are utilized for the DTI task through an output network. The experimental results indicate that LLM$^3$-DTI can proficiently identify validated DTIs, surpassing the performance of the models employed for comparison across diverse scenarios. Consequently, LLM$^3$-DTI is adept at fulfilling the task of DTI prediction with excellence. The data and code are available at https://github.com/chaser-gua/LLM3DTI.

This paper presents Two-Stage LKPLO, a novel multi-stage outlier detection framework that overcomes the coexisting limitations of conventional projection-based methods: their reliance on a fixed statistical metric and their assumption of a single data structure. Our framework uniquely synthesizes three key concepts: (1) a generalized loss-based outlyingness measure (PLO) that replaces the fixed metric with flexible, adaptive loss functions like our proposed SVM-like loss; (2) a global kernel PCA stage to linearize non-linear data structures; and (3) a subsequent local clustering stage to handle multi-modal distributions. Comprehensive 5-fold cross-validation experiments on 10 benchmark datasets, with automated hyperparameter optimization, demonstrate that Two-Stage LKPLO achieves state-of-the-art performance. It significantly outperforms strong baselines on datasets with challenging structures where existing methods fail, most notably on multi-cluster data (Optdigits) and complex, high-dimensional data (Arrhythmia). Furthermore, an ablation study empirically confirms that the synergistic combination of both the kernelization and localization stages is indispensable for its superior performance. This work contributes a powerful new tool for a significant class of outlier detection problems and underscores the importance of hybrid, multi-stage architectures.

As data collection and simulation capabilities advance, multi-modal learning, the task of learning from multiple modalities and sources of data, is becoming an increasingly important area of research. Surrogate models that learn from data of multiple auxiliary modalities to support the modeling of a highly expensive quantity of interest have the potential to aid outer loop applications such as optimization, inverse problems, or sensitivity analyses when multi-modal data are available. We develop two multi-modal Bayesian neural network surrogate models and leverage conditionally conjugate distributions in the last layer to estimate model parameters using stochastic variational inference (SVI). We provide a method to perform this conjugate SVI estimation in the presence of partially missing observations. We demonstrate improved prediction accuracy and uncertainty quantification compared to uni-modal surrogate models for both scalar and time series data.

Generalized Probabilistic Canonical Correlation Analysis for Multi-modal Data Integration with Full or Partial Observations Tianjian Y ang 1 and Wei Vivian Li 1,* 1 Department of Statistics, University of California, Riverside * T o whom correspondence should be addressed: weil@ucr.edu Abstract Background: The integration and analysis of multi-modal data are increasingly essential across various domains including bioinformatics. As the volume and complexity of such data grow, there is a pressing need for computational models that not only integrate diverse modalities but also leverage their complementary information to improve clustering accuracy and insights, especially when dealing with partial observations with missing data. Results: We propose Generalized Probabilistic Canonical Correlation Analysis (GPCCA), an unsupervised method for the integration and joint dimensionality reduction of multi-modal data. GPCCA addresses key challenges in multi-modal data analysis by handling missing values within the model, enabling the integration of more than two modalities, and identifying informative features while accounting for correlations within individual modalities. The model demonstrates robustness to various missing data patterns and provides low-dimensional embeddings that facilitate downstream clustering and analysis. In a range of simulation settings, GPCCA outperforms existing methods in capturing essential patterns across modalities. Additionally, we demonstrate its applicability to multi-omics data from TCGA cancer datasets and a multi-view image dataset. Conclusion: GPCCA offers a useful framework for multi-modal data integration, effectively handling missing data and providing informative low-dimensional embeddings. Its performance across cancer genomics and multi-view image data highlights its robustness and potential for broad application. T o make the method accessible to the wider research community, we have released an R package, GPCCA, which is available at https://github.com/Kaversoniano/ GPCCA . 1 Introduction Many real-world datasets can be described from multiple perspectives, where each perspective, typically represented as a matrix, corresponds to a data modality . A dataset that is consisted of multiple modalities collected from the same set of individuals is termed a multi-modal dataset [1]. Examples include medical imaging data combining computed tomography (CT) and magnetic 1 arXiv:2504.11610v1 T echnological advances have made the collection of multi-modal data increasingly prevalent, enabling integrative analyses that leverage information across modalities.