The microscopic examination of surgical tissue remains a cornerstone of disease classification but relies on subjective interpretations and access to highly specialized experts, which can compromise accuracy and clinical care. While emerging breakthroughs in artificial intelligence (AI) offer promise for automated histological analysis, the growing number of proprietary digital pathology solutions has created barriers to real-world deployment. To address these challenges, we introduce OnSight Pathology, a platform-agnostic computer vision software that uses continuous custom screen captures to provide real-time AI inferences to users as they review digital slide images. Accessible as a single, self-contained executable file (https://onsightpathology.github.io/ ), OnSight Pathology operates locally on consumer-grade personal computers without complex software integration, enabling cost-effective and secure deployment in research and clinical workflows. Here we demonstrate the utility of OnSight Pathology using over 2,500 publicly available whole slide images across different slide viewers, as well as cases from our clinical digital pathology setup. The software's robustness is highlighted across routine histopathological tasks, including the classification of common brain tumor types, mitosis detection, and the quantification of immunohistochemical stains. A built-in multi-modal chat assistant provides verifiable descriptions of images, free of rigid class labels, for added quality control. Lastly, we show compatibility with live microscope camera feeds, including from personal smartphones, offering potential for deployment in more analog, inter-operative, and telepathology settings. Together, we highlight how OnSight Pathology can deliver real-time AI inferences across a broad range of pathology pipelines, removing key barriers to the adoption of AI tools in histopathology.

Reliable data quality is crucial for downstream analysis of tabular datasets, yet rule-based validation often struggles with inefficiency, human intervention, and high computational costs. We present a three-stage framework that combines statistical inliner detection with LLM-driven rule and code generation. After filtering data samples through traditional clustering, we iteratively prompt LLMs to produce semantically valid quality rules and synthesize their executable validators through code-generating LLMs. To generate reliable quality rules, we aid LLMs with retrieval-augmented generation (RAG) by leveraging external knowledge sources and domain-specific few-shot examples. Robust guardrails ensure the accuracy and consistency of both rules and code snippets. Extensive evaluations on benchmark datasets confirm the effectiveness of our approach.

Prof. Dr. Bilge Ayca Kirmizi, akarabork@yahoo.com 1 Introduction Nottingham Grading System [1] emphasizes three key morphological features on Hematoxylin and Eosin (H&E) stained slides to grade breast cancer: mitotic count, tubule formation, and nuclear pleomorphism. Mitotic count is the most prominent feature among them. Searching for mitosis on glass slides is a routine procedure for breast pathologists. Since there are so many high power fields (HPFs) on a single slide and mitotic cells vary in appearance, it is a tedious and time - consuming task. Additionally, mitotic cell judgment is somewhat subjective, making it difficult for pathologists to reach a consensus. Thus, it is extremely important to develop automatic detection methods that will not only save time and material resources, but will also enhance the reliability of pathological diagnosis.

Background: The mitotic count in breast carcinoma is an important prognostic marker. Unfortunately substantial inter- and intra-laboratory variation exists when pathologists manually count mitotic figures. Artificial intelligence (AI) coupled with whole slide imaging offers a potential solution to this problem. The aim of this study was to accordingly critique an AI tool developed to quantify mitotic figures in whole slide images of invasive breast ductal carcinoma. Methods: A representative H&E slide from 320 breast invasive ductal carcinoma cases was scanned at 40x magnification.

How often are you in a situation where you have 2 alternatives either yes or a no, black or a white, and so on. These are instances where you'classify' your scenario into only two solutions, a number of solutions may vary but usually, they are two solutions. This is what we call as'Classification' we classify the outcomes in a set number of instances usually two. This week at The Datum we have how can we use Neural Networks as the classification model. And once we have the model in hands we will go about prediction using the model and lastly, we will evaluate our model and predictions for its rightness.

The number of mitoses per tissue area gives an important aggressiveness indication of the invasive breast carcinoma.However, automatic mitosis detection in histology images remains a challenging problem. Traditional methods either employ hand-crafted features to discriminate mitoses from other cells or construct a pixel-wise classifier to label every pixel in a sliding window way. While the former suffers from the large shape variation of mitoses and the existence of many mimics with similar appearance, the slow speed of the later prohibits its use in clinical practice.In order to overcome these shortcomings, we propose a fast and accurate method to detect mitosis by designing a novel deep cascaded convolutional neural network, which is composed of two components. First, by leveraging the fully convolutional neural network, we propose a coarse retrieval model to identify and locate the candidates of mitosis while preserving a high sensitivity.Based on these candidates, a fine discrimination model utilizing knowledge transferred from cross-domain is developed to further single out mitoses from hard mimics.Our approach outperformed other methods by a large margin in 2014 ICPR MITOS-ATYPIA challenge in terms of detection accuracy. When compared with the state-of-the-art methods on the 2012 ICPR MITOSIS data (a smaller and less challenging dataset), our method achieved comparable or better results with a roughly 60 times faster speed.