Brain tumor detection from MRI scans plays a crucial role in early diagnosis and treatment planning. Deep convolutional neural networks (CNNs) have demonstrated strong performance in medical imaging tasks, particularly when pretrained on large datasets. However, it remains unclear which type of pretrained model performs better when only a small dataset is available: those trained on domain-specific medical data or those pretrained on large general datasets. In this study, we systematically evaluate three pretrained CNN architectures for brain tumor classification: RadImageNet DenseNet121 with medical-domain pretraining, EfficientNetV2S, and ConvNeXt-Tiny, which are modern general-purpose CNNs. All models were trained and fine-tuned under identical conditions using a limited-size brain MRI dataset to ensure a fair comparison. Our results reveal that ConvNeXt-Tiny achieved the highest accuracy, followed by EfficientNetV2S, while RadImageNet DenseNet121, despite being pretrained on domain-specific medical data, exhibited poor generalization with lower accuracy and higher loss. These findings suggest that domain-specific pretraining may not generalize well under small-data conditions. In contrast, modern, deeper general-purpose CNNs pretrained on large-scale datasets can offer superior transfer learning performance in specialized medical imaging tasks.

Meningiomas represent the most prevalent form of primary brain tumors, comprising nearly one-third of all diagnosed cases. Accurate delineation of these tumors from MRI scans is crucial for guiding treatment strategies, yet remains a challenging and time-consuming task in clinical practice. Recent developments in deep learning have accelerated progress in automated tumor segmentation; however, many advanced techniques are hindered by heavy computational demands and long training schedules, making them less accessible for researchers and clinicians working with limited hardware. In this work, we propose a novel ensemble-based segmentation approach that combines three distinct architectures: (1) a baseline SegResNet model, (2) an attention-augmented SegResNet with concatenative skip connections, and (3) a dual-decoder U-Net enhanced with attention-gated skip connections (DDUNet). The ensemble aims to leverage architectural diversity to improve robustness and accuracy while significantly reducing training demands. Each baseline model was trained for only 20 epochs and Evaluated on the BraTS-MEN 2025 dataset. The proposed ensemble model achieved competitive performance, with average Lesion-Wise Dice scores of 77.30%, 76.37% and 73.9% on test dataset for Enhancing Tumor (ET), Tumor Core (TC) and Whole Tumor (WT) respectively. These results highlight the effectiveness of ensemble learning for brain tumor segmentation, even under limited hardware constraints. Our proposed method provides a practical and accessible tool for aiding the diagnosis of meningioma, with potential impact in both clinical and research settings.

Precise delineation of meningiomas is crucial for effective radiotherapy (RT) planning, directly influencing treatment efficacy and preservation of adjacent healthy tissues. While automated deep learning approaches have demonstrated considerable potential, achieving consistently accurate clinical segmentation remains challenging due to tumor heterogeneity. Interactive Medical Image Segmentation (IMIS) addresses this challenge by integrating advanced AI techniques with clinical input. However, generic segmentation tools, despite widespread applicability, often lack the specificity required for clinically critical and disease-specific tasks like meningioma RT planning. To overcome these limitations, we introduce Interactive-MEN-RT, a dedicated IMIS tool specifically developed for clinician-assisted 3D meningioma segmentation in RT workflows. The system incorporates multiple clinically relevant interaction methods, including point annotations, bounding boxes, lasso tools, and scribbles, enhancing usability and clinical precision. In our evaluation involving 500 contrast-enhanced T1-weighted MRI scans from the BraTS 2025 Meningioma RT Segmentation Challenge, Interactive-MEN-RT demonstrated substantial improvement compared to other segmentation methods, achieving Dice similarity coefficients of up to 77.6\% and Intersection over Union scores of 64.8\%. These results emphasize the need for clinically tailored segmentation solutions in critical applications such as meningioma RT planning. The code is publicly available at: https://github.com/snuh-rad-aicon/Interactive-MEN-RT

Brain tumors are serious health problems that require early diagnosis due to their high mortality rates. Diagnosing tumors by examining Magnetic Resonance Imaging (MRI) images is a process that requires expertise and is prone to error. Therefore, the need for automated diagnosis systems is increasing day by day. In this context, a robust and explainable Deep Learning (DL) model for the classification of brain tumors is proposed. In this study, a publicly available Figshare dataset containing 3,064 T1-weighted contrast-enhanced brain MRI images of three tumor types was used. First, the classification performance of nine well-known CNN architectures was evaluated to determine the most effective backbone. Among these, EfficientNetV2 demonstrated the best performance and was selected as the backbone for further development. Subsequently, an attention-based MLP-Mixer architecture was integrated into EfficientNetV2 to enhance its classification capability. The performance of the final model was comprehensively compared with basic CNNs and the methods in the literature. Additionally, Grad-CAM visualization was used to interpret and validate the decision-making process of the proposed model. The proposed model's performance was evaluated using the five-fold cross-validation method. The proposed model demonstrated superior performance with 99.50% accuracy, 99.47% precision, 99.52% recall and 99.49% F1 score. The results obtained show that the model outperforms the studies in the literature. Moreover, Grad-CAM visualizations demonstrate that the model effectively focuses on relevant regions of MRI images, thus improving interpretability and clinical reliability. A robust deep learning model for clinical decision support systems has been obtained by combining EfficientNetV2 and attention-based MLP-Mixer, providing high accuracy and interpretability in brain tumor classification.

Accurate differentiation of brain tumor types on magnetic resonance imaging (MRI) is critical for guiding treatment planning in neuro-oncology. Recent advances in large language models (LLMs) have enabled visual question answering (VQA) approaches that integrate image interpretation with natural language reasoning. In this study, we evaluated GPT-4o, GPT-5-nano, GPT-5-mini, and GPT-5 on a curated brain tumor VQA benchmark derived from 3 Brain Tumor Segmentation (BraTS) datasets - glioblastoma (GLI), meningioma (MEN), and brain metastases (MET). Each case included multi-sequence MRI triplanar mosaics and structured clinical features transformed into standardized VQA items. Models were assessed in a zero-shot chain-of-thought setting for accuracy on both visual and reasoning tasks. Results showed that GPT-5-mini achieved the highest macro-average accuracy (44.19%), followed by GPT-5 (43.71%), GPT-4o (41.49%), and GPT-5-nano (35.85%). Performance varied by tumor subtype, with no single model dominating across all cohorts. These findings suggest that GPT-5 family models can achieve moderate accuracy in structured neuro-oncological VQA tasks, but not at a level acceptable for clinical use.

Detecting Glioma, Meningioma, and Pituitary Tumors, and Normal Brain Tissues based on Y olov11 and Y olov8 Deep Learning Models Ahmed M. Taha a, Salah A. Aly b,c, Mohamed F. Darwish d a Dept. of CE, Faculty of Engineering, Egypt University of Informatics, Cairo, Egypt b Faculty of Computing and Data Science, Badya University, Giza, Egypt c CS&Math Branch, Faculty of Science, Fayoum University, Fayoum, Egypt d Dept. of Pathology, Faculty of Medicine, Badya University, Giza, Egypt Abstract --Accurate and quick diagnosis of normal brain tissue Glioma, Meningioma, and Pituitary T umors is crucial for optimal treatment planning and improved medical results. Magnetic Resonance Imaging (MRI) is widely used as a non-invasive diagnostic tool for detecting brain abnormalities, including tumors. However, manual interpretation of MRI scans is often time-consuming, prone to human error, and dependent on highly specialized expertise. This paper proposes an advanced AI-driven technique to detecting glioma, meningioma, and pituitary brain tumors using Y oloV11 and Y oloV8 deep learning models. Methods: Using a transfer learning-based fine-tuning approach, we integrate cutting-edge deep learning techniques with medical imaging to classify brain tumors into four categories: No-T umor, Glioma, Meningioma, and Pituitary T umors.

Brain tumor detection and classification are critical tasks in medical image analysis, particularly in early-stage diagnosis, where accurate and timely detection can significantly improve treatment outcomes. In this study, we apply various statistical and machine learning models to detect and classify brain tumors using brain MRI images. We explore a variety of statistical models including linear, logistic, and Bayesian regressions, and the machine learning models including decision tree, random forest, single-layer perceptron, multi-layer perceptron, convolutional neural network (CNN), recurrent neural network, and long short-term memory. Our findings show that CNN outperforms other models, achieving the best performance. Additionally, we confirm that the CNN model can also work for multi-class classification, distinguishing between four categories of brain MRI images such as normal, glioma, meningioma, and pituitary tumor images. This study demonstrates that machine learning approaches are suitable for brain tumor detection and classification, facilitating real-world medical applications in assisting radiologists with early and accurate diagnosis.

We present VoxelPrompt, an agent-driven vision-language framework that tackles diverse radiological tasks through joint modeling of natural language, image volumes, and analytical metrics. VoxelPrompt is multi-modal and versatile, leveraging the flexibility of language interaction while providing quantitatively grounded image analysis. Given a variable number of 3D medical volumes, such as MRI and CT scans, VoxelPrompt employs a language agent that iteratively predicts executable instructions to solve a task specified by an input prompt. These instructions communicate with a vision network to encode image features and generate volumetric outputs (e.g., segmentations). VoxelPrompt interprets the results of intermediate instructions and plans further actions to compute discrete measures (e.g., tumor growth across a series of scans) and present relevant outputs to the user. We evaluate this framework in a sandbox of diverse neuroimaging tasks, and we show that the single VoxelPrompt model can delineate hundreds of anatomical and pathological features, measure many complex morphological properties, and perform open-language analysis of lesion characteristics. VoxelPrompt carries out these objectives with accuracy similar to that of fine-tuned, single-task models for segmentation and visual question-answering, while facilitating a much larger range of tasks. Therefore, by supporting accurate image processing with language interaction, VoxelPrompt provides comprehensive utility for numerous imaging tasks that traditionally require specialized models to address.