Our nostrils share the workload like coworkers on rotation. Each of our two nostrils smells the world differently. Breakthroughs, discoveries, and DIY tips sent every weekday. If you close one eye or put a finger to your ear, there's an immediate sense of loss. Two eyes help us see the world while two ears enable us to locate sounds.

Low-dose chest computed tomography (LDCT) inherently captures both pulmonary and cardiac structures, offering a unique opportunity for joint assessment of lung and cardiovascular health. However, most existing approaches treat these domains as independent tasks, overlooking their physiological interplay and shared imaging biomarkers. We propose an Explainable Cross-Disease Reasoning Framework that enables interpretable cardiopulmonary risk assessment from a single LDCT scan. The framework introduces an agentic reasoning process that emulates clinical diagnostic thinking-first perceiving pulmonary findings, then reasoning through established medical knowledge, and finally deriving a cardiovascular judgment with explanatory rationale. It integrates three synergistic components: a pulmonary perception module that summarizes lung abnormalities, a knowledge-guided reasoning module that infers their cardiovascular implications, and a cardiac representation module that encodes structural biomarkers. Their outputs are fused to produce a holistic cardiovascular risk prediction that is both accurate and physiologically grounded. Experiments on the NLST cohort demonstrate that the proposed framework achieves state-of-the-art performance for CVD screening and mortality prediction, outperforming single-disease and purely image-based baselines. Beyond quantitative gains, the framework provides human-verifiable reasoning that aligns with cardiological understanding, revealing coherent links between pulmonary abnormalities and cardiac stress mechanisms. Overall, this work establishes a unified and explainable paradigm for cardiovascular analysis from LDCT, bridging the gap between image-based prediction and mechanism-based medical interpretation.

Low-dose computed tomography (LDCT) is the current standard for lung cancer screening, yet its adoption and accessibility remain limited. Many regions lack LDCT infrastructure, and even among those screened, early-stage cancer detection often yield false positives, as shown in the National Lung Screening Trial (NLST) with a sensitivity of 93.8 percent and a false-positive rate of 26.6 percent. We aim to investigate whether X-ray dark-field imaging (DFI) radiograph, a technique sensitive to small-angle scatter from alveolar microstructure and less susceptible to organ shadowing, can significantly improve early-stage lung tumor detection when coupled with deep-learning segmentation. Using paired attenuation (ATTN) and DFI radiograph images of euthanized mouse lungs, we generated realistic synthetic tumors with irregular boundaries and intensity profiles consistent with physical lung contrast. A U-Net segmentation network was trained on small patches using either ATTN, DFI, or a combination of ATTN and DFI channels. Results show that the DFI-only model achieved a true-positive detection rate of 83.7 percent, compared with 51 percent for ATTN-only, while maintaining comparable specificity (90.5 versus 92.9 percent). The combined ATTN and DFI input achieved 79.6 percent sensitivity and 97.6 percent specificity. In conclusion, DFI substantially improves early-tumor detectability in comparison to standard attenuation radiography and shows potential as an accessible, low-cost, low-dose alternative for pre-clinical or limited-resource screening where LDCT is unavailable.

Health Fitness & Exercise Deep sighs are not only satisfying--they're healthy Those deep breaths can really help your lungs. Breakthroughs, discoveries, and DIY tips sent every weekday. There's something to be said about a good sigh . Sometimes that deep exhale doesn't just feel psychologically satisfying, but physically restorative. According to a study published in the journal, new evidence indicates sighing truly is a way to help reset your body--specifically, the fluid that coats your lungs .

We would like to thank all reviewers for their time and effort writing these valuable reviews. Reviewer 3 mentioned that a performance measure with other recent methods would be beneficial. The code for this paper will be released with the camera-ready version. In the following, we focus on the questions given by Reviewer 2. The presented network does not contain fewer parameters compared to the classical B-spline method for optimization. Furthermore, it is straightforward to extend for the 3D case.

We propose a two-stage multimodal framework that enhances disease classification and region-aware radiology report generation from chest X-rays, leveraging the MIMIC-Eye dataset. In the first stage, we introduce a gaze-guided contrastive learning architecture for disease classification. It integrates visual features, clinical labels, bounding boxes, and radiologist eye-tracking signals and is equipped with a novel multi-term gaze-attention loss combining MSE, KL divergence, correlation, and center-of-mass alignment. Incorporating fixations improves F1 score from 0.597 to 0.631 (+5.70%) and AUC from 0.821 to 0.849 (+3.41%), while also improving precision and recall, highlighting the effectiveness of gaze-informed attention supervision. In the second stage, we present a modular report generation pipeline that extracts confidence-weighted diagnostic keywords, maps them to anatomical regions using a curated dictionary constructed from domain-specific priors, and generates region-aligned sentences via structured prompts. This pipeline improves report quality as measured by clinical keyword recall and ROUGE overlap. Our results demonstrate that integrating gaze data improves both classification performance and the interpretability of generated medical reports.

Agentic Artificial Intelligence (AI) systems leveraging Large Language Models (LLMs) exhibit significant potential for complex reasoning, planning, and tool utilization. We demonstrate that a specialized computer vision system can be built autonomously from a natural language prompt using Agentic AI methods. This involved extending SimpleMind (SM), an open-source Cognitive AI environment with configurable tools for medical image analysis, with an LLM-based agent, implemented using OpenManus, to automate the planning (tool configuration) for a particular computer vision task. We provide a proof-of-concept demonstration that an agentic system can interpret a computer vision task prompt, plan a corresponding SimpleMind workflow by decomposing the task and configuring appropriate tools. From the user input prompt, "provide sm (SimpleMind) config for lungs, heart, and ribs segmentation for cxr (chest x-ray)"), the agent LLM was able to generate the plan (tool configuration file in YAML format), and execute SM-Learn (training) and SM-Think (inference) scripts autonomously. The computer vision agent automatically configured, trained, and tested itself on 50 chest x-ray images, achieving mean dice scores of 0.96, 0.82, 0.83, for lungs, heart, and ribs, respectively. This work shows the potential for autonomous planning and tool configuration that has traditionally been performed by a data scientist in the development of computer vision applications.