Research shows that people who sleep poorly tend to have brain age that is older than their actual age. Chronic inflammation in the body caused by poor sleep likely plays a part. While the link between poor sleep and dementia has long been known, it was unclear whether poor sleep habits could cause dementia or whether poor sleep was an early symptom of dementia. However, new research has revealed that sleep quality may have a direct impact on the rate at which the brain ages . Our findings provide evidence that poor sleep may contribute to accelerated brain aging, explains Abigail Dove, a neuroepidemiologist at the Karolinska Institute in Sweden, and point to inflammation as one of the underlying mechanisms.

From its role in kissing to mythological healing powers, mistletoe's roots run deep. This novella was the earliest and most popular of Dickens' Christmas stories. The kissing under mistletoe (left) and evergreen decoration hanging from the ceiling are vestiges of pre-Christian winter rites. Breakthroughs, discoveries, and DIY tips sent every weekday. It's hard to imagine a holiday season without Bing Crosby's Christmas standard Originally written from the perspective of a soldier stationed overseas during World War II, his longing for the simple comforts of home and reconnecting with his loved ones at Christmas is almost palpable: " Mistletoe just inexplicably feels familiar. Every December, the evergreen sprig s that spent the offseason hidden in our subconscious are suddenly all around us. Mistletoe is the long-lost acquaintance that we instantly recognize and embrace, yet whose backstory has been lost to us. "When I talk to people about parasitic plants, I know mistletoe is the one that they'll immediately recognize even if they don't really know it's a parasite," Virginia Tech plant biologist Jim Westwood tells . Author Washington Irving, best known for The Legend of Sleepy Hollow and is often credited with helping popularize the parasitic evergreen shrub in the United States. He wrote about the plant in an 1820 collection of short stories, but the roots of mistletoe go much deeper elsewhere in the world. Dating back to Ancient Greece and Rome, leafy mistletoe has long excited the imagination. Mistletoe served as a centerpiece of Celtic Rituals and Norse myths, where it bestowed life and fertility and served as an aphrodisiac, a plant of parley, an antidote for poisons, and a means of safe passage to and from Hades. According to The Living Lore, since the plant can thrive in the high branches of its host without soil, "many cultures saw mistletoe as a sacred plant, existing in liminal spaces between life and death, earth and sky, and human and divine." In Old Norse mythology, Baldr, the son of the god Odin and the goddess Frigg, was slain with a mistletoe spear. Some interpretations suggest that, "kissing under the mistletoe symbolizes forgiveness, echoing Frigg's grief and eventual reconciliation with the plant." Many early physicians and scientists saw mistletoe as a cure-all for the woes of the world. It was used to treat various diseases and conditions including epilepsy, infertility, and ulcers. In Pliny's, the writer and physician describes the Celtic ritual of oak and mistletoe. High priests dressed in white harvested mistletoe with golden sickles from the branches of sacred oak trees to make an elixir that could counteract any poison and render any barren animal fertile. "It's easy to imagine how people become fixated on mistletoe plants," says Westwood. "It stays green all winter growing in its host tree.

Given the significant advances in Large Vision Language Models (LVLMs) in reasoning and visual understanding, mobile agents are rapidly emerging to meet users' automation needs. However, existing evaluation benchmarks are disconnected from the real world and fail to adequately address the diverse and complex requirements of users. From our extensive collection of user questionnaire, we identified five tasks: Multi-App, Vague, Interactive, Single-App, and Unethical Instructions. Around these tasks, we present \textbf{MVISU-Bench}, a bilingual benchmark that includes 404 tasks across 137 mobile applications. Furthermore, we propose Aider, a plug-and-play module that acts as a dynamic prompt prompter to mitigate risks and clarify user intent for mobile agents. Our Aider is easy to integrate into several frameworks and has successfully improved overall success rates by 19.55\% compared to the current state-of-the-art (SOTA) on MVISU-Bench. Specifically, it achieves success rate improvements of 53.52\% and 29.41\% for unethical and interactive instructions, respectively. Through extensive experiments and analysis, we highlight the gap between existing mobile agents and real-world user expectations.

Millions of users leverage generative pretrained transformer (GPT)-based language models developed by leading model providers for a wide range of tasks. To support enhanced user interaction and customization, many platforms-such as OpenAI-now enable developers to create and publish tailored model instances, known as custom GPTs, via dedicated repositories or application stores. These custom GPTs empower users to browse and interact with specialized applications designed to meet specific needs. However, as custom GPTs see growing adoption, concerns regarding their security vulnerabilities have intensified. Existing research on these vulnerabilities remains largely theoretical, often lacking empirical, large-scale, and statistically rigorous assessments of associated risks. In this study, we analyze 14,904 custom GPTs to assess their susceptibility to seven exploitable threats, such as roleplay-based attacks, system prompt leakage, phishing content generation, and malicious code synthesis, across various categories and popularity tiers within the OpenAI marketplace. We introduce a multi-metric ranking system to examine the relationship between a custom GPT's popularity and its associated security risks. Our findings reveal that over 95% of custom GPTs lack adequate security protections. The most prevalent vulnerabilities include roleplay-based vulnerabilities (96.51%), system prompt leakage (92.20%), and phishing (91.22%). Furthermore, we demonstrate that OpenAI's foundational models exhibit inherent security weaknesses, which are often inherited or amplified in custom GPTs. These results highlight the urgent need for enhanced security measures and stricter content moderation to ensure the safe deployment of GPT-based applications.

Birth weight (BW) is a key indicator of neonatal health, with low birth weight (LBW) linked to increased mortality and morbidity. Early prediction of BW enables timely interventions; however, current methods like ultrasonography have limitations, including reduced accuracy before 20 weeks and operator dependent variability. Existing models often neglect nutritional and genetic influences, focusing mainly on physiological and lifestyle factors. This study presents an attention-based transformer model with a multi-encoder architecture for early (less than 12 weeks of gestation) BW prediction. Our model effectively integrates diverse maternal data such as physiological, lifestyle, nutritional, and genetic, addressing limitations seen in prior attention-based models such as TabNet. The model achieves a Mean Absolute Error (MAE) of 122 grams and an R-squared value of 0.94, demonstrating high predictive accuracy and interoperability with our in-house private dataset. Independent validation confirms generalizability (MAE: 105 grams, R-squared: 0.95) with the IEEE children dataset. To enhance clinical utility, predicted BW is classified into low and normal categories, achieving a sensitivity of 97.55% and a specificity of 94.48%, facilitating early risk stratification. Model interpretability is reinforced through feature importance and SHAP analyses, highlighting significant influences of maternal age, tobacco exposure, and vitamin B12 status, with genetic factors playing a secondary role. Our results emphasize the potential of advanced deep-learning models to improve early BW prediction, offering clinicians a robust, interpretable, and personalized tool for identifying pregnancies at risk and optimizing neonatal outcomes.

AC Future and Pininfarina unveil AI Transformer homes, merging sustainability and innovation. Kurt Knutsson says this could change the way we think about home. AC Future, a leading developer of AI-enabled sustainable living solutions, has partnered with world-renowned Italian design house Pininfarina to create a groundbreaking collection of transformable living spaces. This innovative collaboration has resulted in three distinct products: AI-THd (AI Transformer Home Drivable), AI-THu (AI Transformer Home Unit) and AI-THt (AI Transformer Home Trailer). Enter the giveaway by signing up for my free newsletter.

The COVID-19 pandemic has significantly transformed global lifestyles, enforcing physical isolation and accelerating digital adoption for work, education, and social interaction. This study examines the pandemic's impact on mental health by analyzing dream content shared on the Reddit r/Dreams community. With over 374,000 subscribers, this platform offers a rich dataset for exploring subconscious responses to the pandemic. Using statistical methods, we assess shifts in dream positivity, negativity, and neutrality from the pre-pandemic to post-pandemic era. To enhance our analysis, we fine-tuned the LLaMA 3.1-8B model with labeled data, enabling precise sentiment classification of dream content. Our findings aim to uncover patterns in dream content, providing insights into the psychological effects of the pandemic and its influence on subconscious processes. This research highlights the profound changes in mental landscapes and the role of dreams as indicators of public well-being during unprecedented times.

This study explored how lifestyle, personal background, and family history contribute to the risk of developing Alcohol Use Disorder (AUD). Survey data from the All of Us Program was utilized to extract information on AUD status, lifestyle, personal background, and family history for 6,016 participants. Key determinants of AUD were identified using decision trees including annual income, recreational drug use, length of residence, sex/gender, marital status, education level, and family history of AUD. Data visualization and Chi-Square Tests of Independence were then used to assess associations between identified factors and AUD. Afterwards, machine learning techniques including decision trees, random forests, and Naive Bayes were applied to predict an individual's likelihood of developing AUD. Random forests were found to achieve the highest accuracy (82%), compared to Decision Trees and Naive Bayes. Findings from this study can offer insights that help parents, healthcare professionals, and educators develop strategies to reduce AUD risk, enabling early intervention and targeted prevention efforts.

Blood biomarkers are an essential tool for healthcare providers to diagnose, monitor, and treat a wide range of medical conditions. Current reference values and recommended ranges often rely on population-level statistics, which may not adequately account for the influence of inter-individual variability driven by factors such as lifestyle and genetics. In this work, we introduce a novel framework for predicting future blood biomarker values and define personalized references through learned representations from lifestyle data (physical activity and sleep) and blood biomarkers. Our proposed method learns a similarity-based embedding space that captures the complex relationship between biomarkers and lifestyle factors. Using the UK Biobank (257K participants), our results show that our deep-learned embeddings outperform traditional and current state-of-the-art representation learning techniques in predicting clinical diagnosis. Using a subset of UK Biobank of 6440 participants who have follow-up visits, we validate that the inclusion of these embeddings and lifestyle factors directly in blood biomarker models improves the prediction of future lab values from a single lab visit. This personalized modeling approach provides a foundation for developing more accurate risk stratification tools and tailoring preventative care strategies. In clinical settings, this translates to the potential for earlier disease detection, more timely interventions, and ultimately, a shift towards personalized healthcare.

Fox News Flash top headlines are here. Check out what's clicking on Foxnews.com. The journey toward improved mental health by setting thoughtful and achievable goals can be a powerful strategy. Whether grappling with anxiety, depression, ADHD or other conditions, establishing personalized goals fosters a sense of direction, accomplishment and empowerment. Explore specific goals tailored to each condition, promoting overall mental well-being.