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Artificial intelligence techniques in inherited retinal diseases: A review

Trinh, Han, Vice, Jordan, Charng, Jason, Tajbakhsh, Zahra, Alam, Khyber, Chen, Fred K., Mian, Ajmal

arXiv.org Artificial Intelligence

Inherited retinal diseases (IRDs) are a diverse group of genetic disorders that lead to progressive vision loss and are a major cause of blindness in working-age adults. The complexity and heterogeneity of IRDs pose significant challenges in diagnosis, prognosis, and management. Recent advancements in artificial intelligence (AI) offer promising solutions to these challenges. However, the rapid development of AI techniques and their varied applications have led to fragmented knowledge in this field. This review consolidates existing studies, identifies gaps, and provides an overview of AI's potential in diagnosing and managing IRDs. It aims to structure pathways for advancing clinical applications by exploring AI techniques like machine learning and deep learning, particularly in disease detection, progression prediction, and personalized treatment planning. Special focus is placed on the effectiveness of convolutional neural networks in these areas. Additionally, the integration of explainable AI is discussed, emphasizing its importance in clinical settings to improve transparency and trust in AI-based systems. The review addresses the need to bridge existing gaps in focused studies on AI's role in IRDs, offering a structured analysis of current AI techniques and outlining future research directions. It concludes with an overview of the challenges and opportunities in deploying AI for IRDs, highlighting the need for interdisciplinary collaboration and the continuous development of robust, interpretable AI models to advance clinical applications.



Policy Learning with a Language Bottleneck

Srivastava, Megha, Colas, Cedric, Sadigh, Dorsa, Andreas, Jacob

arXiv.org Artificial Intelligence

Modern AI systems such as self-driving cars and game-playing agents achieve superhuman performance, but often lack human-like features such as generalization, interpretability and human inter-operability. Inspired by the rich interactions between language and decision-making in humans, we introduce Policy Learning with a Language Bottleneck (PLLB), a framework enabling AI agents to generate linguistic rules that capture the strategies underlying their most rewarding behaviors. PLLB alternates between a rule generation step guided by language models, and an update step where agents learn new policies guided by rules. In a two-player communication game, a maze solving task, and two image reconstruction tasks, we show that PLLB agents are not only able to learn more interpretable and generalizable behaviors, but can also share the learned rules with human users, enabling more effective human-AI coordination.


BIRD: A Trustworthy Bayesian Inference Framework for Large Language Models

Feng, Yu, Zhou, Ben, Lin, Weidong, Roth, Dan

arXiv.org Artificial Intelligence

Large language models primarily rely on inductive reasoning for decision making. This results in unreliable decisions when applied to real-world tasks that often present incomplete contexts and conditions. Thus, accurate probability estimation and appropriate interpretations are required to enhance decision-making reliability. In this paper, we propose a Bayesian inference framework called BIRD for large language models. BIRD provides controllable and interpretable probability estimation for model decisions, based on abductive factors, LLM entailment, as well as learnable deductive Bayesian modeling. Experiments show that BIRD produces probability estimations that align with human judgments over 65% of the time using open-sourced Llama models, outperforming the state-of-the-art GPT-4 by 35%. We also show that BIRD can be directly used for trustworthy decision making on many real-world applications.