Normative modeling estimates reference distributions of biological measures conditional on covariates, enabling centiles and clinically interpretable deviation scores to be derived. Most neuroimaging pipelines fit one model per imaging-derived phenotype (IDP), which scales well but discards multivariate dependence that may encode coordinated patterns. We propose denoising diffusion probabilistic models (DDPMs) as a unified conditional density estimator for tabular IDPs, from which univariate centiles and deviation scores are derived by sampling. We utilise two denoiser backbones: (i) a feature-wise linear modulation (FiLM) conditioned multilayer perceptron (MLP) and (ii) a tabular transformer with feature self-attention and intersample attention (SAINT), conditioning covariates through learned embeddings. We evaluate on a synthetic benchmark with heteroscedastic and multimodal age effects and on UK Biobank FreeSurfer phenotypes, scaling from dimension of 2 to 200. Our evaluation suite includes centile calibration (absolute centile error, empirical coverage, and the probability integral transform), distributional fidelity (Kolmogorov-Smirnov tests), multivariate dependence diagnostics, and nearest-neighbour memorisation analysis. For low dimensions, diffusion models deliver well-calibrated per-IDP outputs comparable to traditional baselines while jointly modeling realistic dependence structure. At higher dimensions, the transformer backbone remains substantially better calibrated than the MLP and better preserves higher-order dependence, enabling scalable joint normative models that remain compatible with standard per-IDP pipelines. These results support diffusion-based normative modeling as a practical route to calibrated multivariate deviation profiles in neuroimaging.

This paper presents an intelligent work automation approach in the context of contemporary digital transformation by integrating generative AI and Intelligent Document Processing (IDP) technologies with an Automation Agent to realize End-to-End (E2E) automation of corporate financial expense processing tasks. While traditional Robotic Process Automation (RPA) has proven effective for repetitive, rule-based simple task automation, it faces limitations in handling unstructured data, exception management, and complex decision-making. This study designs and implements a four-stage integrated process comprising automatic recognition of supporting documents such as receipts via OCR/IDP, item classification based on a policy-driven database, intelligent exception handling supported by generative AI (large language models, LLMs), and human-in-the-loop final decision-making with continuous system learning through an Automation Agent. Applied to a major Korean enterprise (Company S), the system demonstrated quantitative benefits including over 80% reduction in processing time for paper receipt expense tasks, decreased error rates, and improved compliance, as well as qualitative benefits such as enhanced accuracy and consistency, increased employee satisfaction, and data-driven decision support. Furthermore, the system embodies a virtuous cycle by learning from human judgments to progressively improve automatic exception handling capabilities. Empirically, this research confirms that the organic integration of generative AI, IDP, and Automation Agents effectively overcomes the limitations of conventional automation and enables E2E automation of complex corporate processes. The study also discusses potential extensions to other domains such as accounting, human resources, and procurement, and proposes future directions for AI-driven hyper-automation development.

Abstract-- Autonomous LLM agents can issue thousands of API calls per hour without human oversight. OAuth 2.0 assumes deterministic clients, but in agentic settings stochastic reasoning, prompt injection, or multi-agent orchestration can silently expand privileges. This paper describes Agentic JWT (A-JWT), a dual-faceted token design that binds each agent action to a cryptographically verifiable user intent and optionally to a workflow step. A-JWT carries an agent's identity as a one-way checksum hash derived from its prompt, tools and configuration and a chained delegation assertion to prove which downstream agent may execute a given task. The design also uses per-agent proof-of-possession keys to prevent replay and in-process impersonation. The paper introduces a new unique authorization grant called'agent_checksum' and adds a lightweight client shim library that self-verifies code at run time, mints intent tokens, tracks workflow steps and derives keys thus enabling secure agent identity and separation even within a single process. We illustrate a comprehensive threat model for agentic applications, implement a Python proof-of-concept, and show functional blocking of scope-violating requests, replay, impersonation, and prompt-injection pathways with sub-millisecond overhead on commodity hardware. The design aligns with ongoing OAuth agent discussions and offers a drop-in path toward zero-trust guarantees for agentic applications. A comprehensive performance and security evaluation with experimental results will appear in our forthcoming journal submission. I. Introduction AI Agents are not a theoretical phenomenon anymore. Large enterprises now use AI agents [1], to possibly execute millions of API calls per hour. Major cloud LLMs now serve hundreds of millions of API requests per day, for example Baidu's ERNIE handles approximately 200 M daily queries, providing the raw horsepower that agent frameworks build on [2], yet those calls still ride on OAuth tokens designed for deterministic clients. A quick peek into the scale of operations and future trends would reveal that the volume of AI Agent activity has grown dramatically, underscoring their operational impact. Baidu's large volume of API calls per day has seen a 4 fold increase in just a few months [2]. A recent cloud survey found OpenAI/Azure AI services are used in 67% of cloud deployments, alongside a rise in self-hosted AI models across 75% of organizations [3].

Trustworthy interpretation of deep learning models is critical for neuroimaging applications, yet commonly used Explainable AI (XAI) methods lack rigorous validation, risking misinterpretation. We performed the first large-scale, systematic comparison of XAI methods on ~45,000 structural brain MRIs using a novel XAI validation framework. This framework establishes verifiable ground truth by constructing prediction tasks with known signal sources - from localized anatomical features to subject-specific clinical lesions - without artificially altering input images. Our analysis reveals systematic failures in two of the most widely used methods: GradCAM consistently failed to localize predictive features, while Layer-wise Relevance Propagation generated extensive, artifactual explanations that suggest incompatibility with neuroimaging data characteristics. Our results indicate that these failures stem from a domain mismatch, where methods with design principles tailored to natural images require substantial adaptation for neuroimaging data. In contrast, the simpler, gradient-based method SmoothGrad, which makes fewer assumptions about data structure, proved consistently accurate, suggesting its conceptual simplicity makes it more robust to this domain shift. These findings highlight the need for domain-specific adaptation and validation of XAI methods, suggest that interpretations from prior neuroimaging studies using standard XAI methodology warrant re-evaluation, and provide urgent guidance for practical application of XAI in neuroimaging.

Searching for planets analogous to Earth in terms of mass and equilibrium temperature is currently the first step in the quest for habitable conditions outside our Solar System and, ultimately, the search for life in the universe. Future missions such as PLATO or LIFE will begin to detect and characterise these small, cold planets, dedicating significant observation time to them. The aim of this work is to predict which stars are most likely to host an Earth-like planet (ELP) to avoid blind searches, minimises detection times, and thus maximises the number of detections. Using a previous study on correlations between the presence of an ELP and the properties of its system, we trained a Random Forest to recognise and classify systems as 'hosting an ELP' or 'not hosting an ELP'. The Random Forest was trained and tested on populations of synthetic planetary systems derived from the Bern model, and then applied to real observed systems. The tests conducted on the machine learning (ML) model yield precision scores of up to 0.99, indicating that 99% of the systems identified by the model as having ELPs possess at least one. Among the few real observed systems that have been tested, 44 have been selected as having a high probability of hosting an ELP, and a quick study of the stability of these systems confirms that the presence of an Earth-like planet within them would leave them stable. The excellent results obtained from the tests conducted on the ML model demonstrate its ability to recognise the typical architectures of systems with or without ELPs within populations derived from the Bern model. If we assume that the Bern model adequately describes the architecture of real systems, then such a tool can prove indispensable in the search for Earth-like planets. A similar approach could be applied to other planetary system formation models to validate those predictions.

Large language models (LLMs), while transformative for NLP, come with significant computational demands, underlining the need for efficient, training-free compression. Notably, despite the marked improvement in training-free compression for the largest of LLMs, our tests using LLaMA-7B and OPT-6.7b highlight a significant performance drop in several realistic downstream tasks. Investigation into the trade-off between resource-intensive post-compression re-training highlights the prospect of prompt-driven recovery as a lightweight adaption tool. However, existing studies, confined mainly to perplexity evaluations and simple tasks, fail to offer unequivocal confidence in the scalability and generalizability of prompting. We tackle this uncertainty in two key ways. First, we uncover the vulnerability of naive prompts in LLM compression as an over-reliance on a singular prompt per input. In response, we propose inference-time dynamic prompting (IDP), a mechanism that autonomously chooses from a set of curated prompts based on the context of each individual input. Second, we delve into a scientific understanding of why "prompting might be all you need post-LLM compression." Our findings suggest that compression does not irretrievably erase LLM model knowledge but displace it, necessitating a new inference path. IDP effectively redirects this path, enabling the model to tap into its inherent yet displaced knowledge and thereby recover performance. Empirical tests affirm the value of IDP, demonstrating an average performance improvement of 1.24% across nine varied tasks spanning multiple knowledge domains.

Early diagnosis of Type 2 Diabetes Mellitus (T2DM) is crucial to enable timely therapeutic interventions and lifestyle modifications. As the time available for clinical office visits shortens and medical imaging data become more widely available, patient image data could be used to opportunistically identify patients for additional T2DM diagnostic workup by physicians. We investigated whether image-derived phenotypic data could be leveraged in tabular learning classifier models to predict T2DM risk in an automated fashion to flag high-risk patients without the need for additional blood laboratory measurements. In contrast to traditional binary classifiers, we leverage neural networks and decision tree models to represent patient data as 'SynthA1c' latent variables, which mimic blood hemoglobin A1c empirical lab measurements, that achieve sensitivities as high as 87.6%. To evaluate how SynthA1c models may generalize to other patient populations, we introduce a novel generalizable metric that uses vanilla data augmentation techniques to predict model performance on input out-of-domain covariates. We show that image-derived phenotypes and physical examination data together can accurately predict diabetes risk as a means of opportunistic risk stratification enabled by artificial intelligence and medical imaging. Our code is available at https://github.com/allisonjchae/DMT2RiskAssessment.

Differentiable planning promises end-to-end differentiability and adaptivity. However, an issue prevents it from scaling up to larger-scale problems: they need to differentiate through forward iteration layers to compute gradients, which couples forward computation and backpropagation, and needs to balance forward planner performance and computational cost of the backward pass. To alleviate this issue, we propose to differentiate through the Bellman fixed-point equation to decouple forward and backward passes for Value Iteration Network and its variants, which enables constant backward cost (in planning horizon) and flexible forward budget and helps scale up to large tasks. We study the convergence stability, scalability, and efficiency of the proposed implicit version of VIN and its variants and demonstrate their superiorities on a range of planning tasks: 2D navigation, visual navigation, and 2-DOF manipulation in configuration space and workspace.

Dynamics and conformational sampling are essential for linking protein structure to biological function. While challenging to probe experimentally, computer simulations are widely used to describe protein dynamics, but at significant computational costs that continue to limit the systems that can be studied. Here, we demonstrate that machine learning can be trained with simulation data to directly generate physically realistic conformational ensembles of proteins without the need for any sampling and at negligible computational cost. As a proof-of-principle we train a generative adversarial network based on a transformer architecture with self-attention on coarse-grained simulations of intrinsically disordered peptides. The resulting model, idpGAN, can predict sequence-dependent coarse-grained ensembles for sequences that are not present in the training set demonstrating that transferability can be achieved beyond the limited training data. We also retrain idpGAN on atomistic simulation data to show that the approach can be extended in principle to higher-resolution conformational ensemble generation. Computational methods to study protein structural dynamics are a powerful tool in life sciences but are computationally expensive. Here, the authors show that machine learning can be used to efficiently generate protein conformational ensembles and test their method on intrinsically disordered peptides.

ChatGPT, the state-of-the-art language model developed by OpenAI, is poised to have a significant impact on the B2B industry. This powerful technology has the potential to disrupt traditional business processes and open up new opportunities for companies across a wide range of industries when it comes to intelligent document processing. One of the key areas where ChatGPT is likely to have an impact is in automating routine tasks and customer interactions. Another area where ChatGPT is likely to be disruptive is in the generation of written content. This technology can be used to quickly and accurately generate reports, product descriptions, and other written materials.