MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) which play key roles in post-transcriptional gene regulation. Direct identification of mature miRNAs is infeasible due to their short lengths, and researchers instead aim at identifying precursor miRNAs (pre-miRNAs). Many of the known pre-miRNAs have distinctive stem-loop secondary structure, and structure-based filtering is usually the first step to predict the possibility of a given sequence being a pre-miRNA. To identify new pre-miRNAs that often have non-canonical structure, however, we need to consider additional features other than structure. To obtain such additional characteristics, existing computational methods rely on manual feature extraction, which inevitably limits the efficiency, robustness, and generalization of computational identification. To address the limitations of existing approaches, we propose a pre-miRNA identification method that incorporates (1) a deep recurrent neural network (RNN) for automated feature learning and classification, (2) multimodal architecture for seamless integration of prior knowledge (secondary structure), (3) an attention mechanism for improving long-term dependence modeling, and (4) an RNN-based class activation mapping for highlighting the learned representations that can contrast pre-miRNAs and non-pre-miRNAs. In our experiments with recent benchmarks, the proposed approach outperformed the compared state-of-the-art alternatives in terms of various performance metrics.

In topic modeling, many algorithms that guarantee identifiability of the topics have been developed under the premise that there exist anchor words -- i.e., words that only appear (with positive probability) in one topic. Follow-up work has resorted to three or higher-order statistics of the data corpus to relax the anchor word assumption. Reliable estimates of higher-order statistics are hard to obtain, however, and the identification of topics under those models hinges on uncorrelatedness of the topics, which can be unrealistic. This paper revisits topic modeling based on second-order moments, and proposes an anchor-free topic mining framework. The proposed approach guarantees the identification of the topics under a much milder condition compared to the anchor-word assumption, thereby exhibiting much better robustness in practice. The associated algorithm only involves one eigen-decomposition and a few small linear programs. This makes it easy to implement and scale up to very large problem instances. Experiments using the TDT2 and Reuters-21578 corpus demonstrate that the proposed anchor-free approach exhibits very favorable performance (measured using coherence, similarity count, and clustering accuracy metrics) compared to the prior art.

Data normalisation, a common and often necessary preprocessing step in engineering and scientific applications, can severely distort the discovery of governing equations by magnitudebased sparse regression methods. This issue is particularly acute for the Sparse Identification of Nonlinear Dynamics (SINDy) framework, where the core assumption of sparsity is undermined by the interaction between data scaling and measurement noise. The resulting discovered models can be dense, uninterpretable, and physically incorrect. To address this critical vulnerability, we introduce the Sequential Thresholding of Coefficient of Variation (STCV), a novel, computationally efficient sparse regression algorithm that is inherently robust to data scaling. STCV replaces conventional magnitude-based thresholding with a dimensionless statistical metric, the Coefficient Presence (CP), which assesses the statistical validity and consistency of candidate terms in the model library. This shift from magnitude to statistical significance makes the discovery process invariant to arbitrary data scaling. Through comprehensive benchmarking on canonical dynamical systems and practical engineering problems, including a physical mass-spring-damper experiment, we demonstrate that STCV consistently and significantly outperforms standard Sequential Thresholding Least Squares (STLSQ) and Ensemble-SINDy (E-SINDy) on normalised, noisy datasets. The results show that STCV-based methods can successfully identify the correct, sparse physical laws even when other methods fail. By mitigating the distorting effects of normalisation, STCV makes sparse system identification a more reliable and automated tool for real-world applications, thereby enhancing model interpretability and trustworthiness.

We study one-sided and $α$-correct sequential hypothesis testing for data generated by an ergodic Markov chain. The null hypothesis is that the unknown transition matrix belongs to a prescribed set $P$ of stochastic matrices, and the alternative corresponds to a disjoint set $Q$. We establish a tight non-asymptotic instance-dependent lower bound on the expected stopping time of any valid sequential test under the alternative. Our novel analysis improves the existing lower bounds, which are either asymptotic or provably sub-optimal in this setting. Our lower bound incorporates both the stationary distribution and the transition structure induced by the unknown Markov chain. We further propose an optimal test whose expected stopping time matches this lower bound asymptotically as $α\to 0$. We illustrate the usefulness of our framework through applications to sequential detection of model misspecification in Markov Chain Monte Carlo and to testing structural properties, such as the linearity of transition dynamics, in Markov decision processes. Our findings yield a sharp and general characterization of optimal sequential testing procedures under Markovian dependence.

This bound naturally breaks into two components.

We propose nonparametric identification and semiparametric estimation of joint potential outcome distributions in the presence of confounding. First, in settings with observed confounding, we derive tighter, covariate-informed bounds on the joint distribution by leveraging conditional copulas. To overcome the non-differentiability of bounding min/max operators, we establish the asymptotic properties for both a direct estimator with polynomial margin condition and a smooth approximation with log-sum-exp operator, facilitating valid inference for individual-level effects under the canonical rank-preserving assumption. Second, we tackle the challenge of unmeasured confounding by introducing a causal representation learning framework. By utilizing instrumental variables, we prove the nonparametric identifiability of the latent confounding subspace under injectivity and completeness conditions. We develop a ``triple machine learning" estimator that employs cross-fitting scheme to sequentially handle the learned representation, nuisance parameters, and target functional. We characterize the asymptotic distribution with variance inflation induced by representation learning error, and provide conditions for semiparametric efficiency. We also propose a practical VAE-based algorithm for confounding representation learning. Simulations and real-world analysis validate the effectiveness of proposed methods. By bridging classical semiparametric theory with modern representation learning, this work provides a robust statistical foundation for distributional and counterfactual inference in complex causal systems.

A plethora of methods was developed for solving this problem, including the celebrated do-calculus [Pearl, 1995]. In practice, these results are not always applicable since they require a fully specified causal diagram as input, which is usually not available.

LLMs with improved chemical reasoning capabilities in the other two sub-tasks.