Hematoxylin and Eosin (H&E) staining is a cornerstone of pathological analysis, offering reliable visualization of cellular morphology and tissue architecture for cancer diagnosis, subtyping, and grading. Immunohistochemistry (IHC) staining provides molecular insights by detecting specific proteins within tissues, enhancing diagnostic accuracy, and improving treatment planning. However, IHC staining is costly, time-consuming, and resource-intensive, requiring specialized expertise. To address these limitations, this study proposes HistoStainAlign, a novel deep learning framework that predicts IHC staining patterns directly from H&E whole-slide images (WSIs) by learning joint representations of morphological and molecular features. The framework integrates paired H&E and IHC embeddings through a contrastive training strategy, capturing complementary features across staining modalities without patch-level annotations or tissue registration. The model was evaluated on gastrointestinal and lung tissue WSIs with three commonly used IHC stains: P53, PD-L1, and Ki-67. HistoStainAlign achieved weighted F1 scores of 0.735 [95% Confidence Interval (CI): 0.670-0.799], 0.830 [95% CI: 0.772-0.886], and 0.723 [95% CI: 0.607-0.836], respectively for these three IHC stains. Embedding analyses demonstrated the robustness of the contrastive alignment in capturing meaningful cross-stain relationships. Comparisons with a baseline model further highlight the advantage of incorporating contrastive learning for improved stain pattern prediction. This study demonstrates the potential of computational approaches to serve as a pre-screening tool, helping prioritize cases for IHC staining and improving workflow efficiency.

We investigate whether hidden states from Structured State Space Models (SSMs) can be merged post-hoc to support downstream reasoning. Inspired by model souping, we propose a strategy where documents are encoded independently and their representations are pooled -- via simple operations like averaging -- into a single context state. This approach, which we call document souping, enables modular encoding and reuse without reprocessing the full input for each query. We finetune Mamba2 models to produce soupable representations and find that they support multi-hop QA, sparse retrieval, and long-document reasoning with strong accuracy. On HotpotQA, souping ten independently encoded documents nearly matches the performance of a cross-encoder trained on the same inputs.

Scaling robot learning requires vast and diverse datasets. Yet the prevailing data collection paradigm-human teleoperation-remains costly and constrained by manual effort and physical robot access. We introduce Real2Render2Real (R2R2R), a novel approach for generating robot training data without relying on object dynamics simulation or teleoperation of robot hardware. The input is a smartphone-captured scan of one or more objects and a single video of a human demonstration. R2R2R renders thousands of high visual fidelity robot-agnostic demonstrations by reconstructing detailed 3D object geometry and appearance, and tracking 6-DoF object motion. R2R2R uses 3D Gaussian Splatting (3DGS) to enable flexible asset generation and trajectory synthesis for both rigid and articulated objects, converting these representations to meshes to maintain compatibility with scalable rendering engines like IsaacLab but with collision modeling off. Robot demonstration data generated by R2R2R integrates directly with models that operate on robot proprioceptive states and image observations, such as vision-language-action models (VLA) and imitation learning policies. Physical experiments suggest that models trained on R2R2R data from a single human demonstration can match the performance of models trained on 150 human teleoperation demonstrations. Project page: https://real2render2real.com

This study explores the capacity of large language models (LLMs) for explicit learning, a process involving the assimilation of metalinguistic explanations to carry out language tasks. Using constructed languages generated by cryptographic means as controlled test environments, we designed experiments to assess an LLM's ability to explicitly learn and apply grammar rules. Our results demonstrate that while LLMs possess a measurable capacity for explicit learning, this ability diminishes as the complexity of the linguistic phenomena at hand increases. Supervised fine-tuning on chains of thought significantly enhances LLM performance but struggles to generalize to typologically novel or more complex linguistic features. These findings point to the need for more diverse training sets and alternative fine-tuning strategies to further improve explicit learning by LLMs.

Open-weight large language models (LLMs) have significantly advanced performance in the Natural Language to SQL (NL2SQL) task. However, their effectiveness diminishes when dealing with large database schemas, as the context length increases. To address this limitation, we present SQLong, a novel and efficient data augmentation framework designed to enhance LLM performance in long-context scenarios for the NL2SQL task. SQLong generates augmented datasets by extending existing database schemas with additional synthetic CREATE TABLE commands and corresponding data rows, sampled from diverse schemas in the training data. This approach effectively simulates long-context scenarios during finetuning and evaluation. Through experiments on the Spider and BIRD datasets, we demonstrate that LLMs finetuned with SQLong-augmented data significantly outperform those trained on standard datasets. These imply SQLong's practical implementation and its impact on improving NL2SQL capabilities in real-world settings with complex database schemas.

Current Speech LLMs are predominantly trained on extensive ASR and TTS datasets, excelling in tasks related to these domains. However, their ability to handle direct speech-to-speech conversations remains notably constrained. We find that Speech LLMs often rely on an ASR-to-TTS chain-of-thought pipeline (A-T-T-A chain) to generate good responses. The pipeline first recognizes speech into text and generates corresponding text responses before generating speech responses, which introduces significant latency. We propose a method that implicitly internalizes ASR chain of thought into a Speech LLM (A-T-A chain), allowing it to bypass the ASR transcript generation but still maintain speech conversation capabilities. Our approach reduces latency and improves the model's native understanding of speech, paving the way for more efficient and natural real-time audio interactions. We also release a large-scale synthetic conversational dataset to facilitate further research.

Assessing the capabilities and limitations of large language models (LLMs) has garnered significant interest, yet the evaluation of multiple models in real-world scenarios remains rare. Multilingual evaluation often relies on translated benchmarks, which typically do not capture linguistic and cultural nuances present in the source language. This study provides an extensive assessment of 24 LLMs on real world data collected from Indian patients interacting with a medical chatbot in Indian English and 4 other Indic languages. We employ a uniform Retrieval Augmented Generation framework to generate responses, which are evaluated using both automated techniques and human evaluators on four specific metrics relevant to our application. We find that models vary significantly in their performance and that instruction tuned Indic models do not always perform well on Indic language queries. Further, we empirically show that factual correctness is generally lower for responses to Indic queries compared to English queries. Finally, our qualitative work shows that code-mixed and culturally relevant queries in our dataset pose challenges to evaluated models.

LiDAR-based 3D object detectors have been largely utilized in various applications, including autonomous vehicles or mobile robots. However, LiDAR-based detectors often fail to adapt well to target domains with different sensor configurations (e.g., types of sensors, spatial resolution, or FOVs) and location shifts. Collecting and annotating datasets in a new setup is commonly required to reduce such gaps, but it is often expensive and time-consuming. Recent studies suggest that pre-trained backbones can be learned in a self-supervised manner with large-scale unlabeled LiDAR frames. However, despite their expressive representations, they remain challenging to generalize well without substantial amounts of data from the target domain. Thus, we propose a novel method, called Domain Adaptive Distill-Tuning (DADT), to adapt a pre-trained model with limited target data (approximately 100 LiDAR frames), retaining its representation power and preventing it from overfitting. Specifically, we use regularizers to align object-level and context-level representations between the pre-trained and finetuned models in a teacher-student architecture. Our experiments with driving benchmarks, i.e., Waymo Open dataset and KITTI, confirm that our method effectively finetunes a pre-trained model, achieving significant gains in accuracy.

Accurate estimates of surface solar irradiance (SSI) are essential for solar resource assessments and solar energy forecasts in grid integration and building control applications. SSI estimates for spatially extended regions can be retrieved from geostationary satellites such as Meteosat. Traditional SSI satellite retrievals like Heliosat rely on physical radiative transfer modelling. We introduce the first machine-learning-based satellite retrieval for instantaneous SSI and demonstrate its capability to provide accurate and generalizable SSI estimates across Europe. Our deep learning retrieval provides near real-time SSI estimates based on data-driven emulation of Heliosat and fine-tuning on pyranometer networks. By including SSI from ground stations, our SSI retrieval model can outperform Heliosat accuracy and generalize well to regions with other climates and surface albedos in cloudy conditions (clear-sky index < 0.8). We also show that the SSI retrieved from Heliosat exhibits large biases in mountain regions, and that training and fine-tuning our retrieval models on SSI data from ground stations strongly reduces these biases, outperforming Heliosat. Furthermore, we quantify the relative importance of the Meteosat channels and other predictor variables like solar zenith angle for the accuracy of our deep learning SSI retrieval model in different cloud conditions. We find that in cloudy conditions multiple near-infrared and infrared channels enhance the performance. Our results can facilitate the development of more accurate satellite retrieval models of surface solar irradiance.

There are various methods for adapting LLMs to different domains. The most common methods are prompting, finetuning, and RAG. In this work, we explore the possibility of adapting a model using one of the PEFT methods - QLoRA. The experiment aims to simulate human responses based on their interviews. The simulation quality is assessed by comparing the quality of the style and the quality of the generated facts.