Quantifiable image patterns associated with disease progression and treatment response are critical tools for guiding individual treatment, and for developing novel therapies. Here, we show that unsupervised machine learning can identify a pattern vocabulary of liver tissue in magnetic resonance images that quantifies treatment response in diffuse liver disease. Deep clustering networks simultaneously encode and cluster patches of medical images into a low-dimensional latent space to establish a tissue vocabulary. The resulting tissue types capture differential tissue change and its location in the liver associated with treatment response. We demonstrate the utility of the vocabulary on a randomized controlled trial cohort of non-alcoholic steatohepatitis patients. First, we use the vocabulary to compare longitudinal liver change in a placebo and a treatment cohort. Results show that the method identifies specific liver tissue change pathways associated with treatment, and enables a better separation between treatment groups than established non-imaging measures. Moreover, we show that the vocabulary can predict biopsy derived features from non-invasive imaging data. We validate the method on a separate replication cohort to demonstrate the applicability of the proposed method.

The primary objective of the AIIB 2023 competition is to evaluate the predictive significance of airway-related imaging biomarkers in determining the survival outcomes of patients with lung fibrosis.This study introduces a comprehensive three-stage approach. Initially, a segmentation network, namely nn-Unet, is employed to delineate the airway's structural boundaries. Subsequently, key features are extracted from the radiomic images centered around the trachea and an enclosing bounding box around the airway. This step is motivated by the potential presence of critical survival-related insights within the tracheal region as well as pertinent information encoded in the structure and dimensions of the airway. Lastly, radiomic features obtained from the segmented areas are integrated into an SVM classifier. We could obtain an overall-score of 0.8601 for the segmentation in Task 1 while 0.7346 for the classification in Task 2.

While the acute phase of the COVID-19 pandemic has subsided, its long-term effects persist through Post-Acute Sequelae of COVID-19 (PASC), commonly known as Long COVID. There remains substantial uncertainty regarding both its duration and optimal management strategies. PASC manifests as a diverse array of persistent or newly emerging symptoms--ranging from fatigue, dyspnea, and neurologic impairments (e.g., brain fog), to cardiovascular, pulmonary, and musculoskeletal abnormalities--that extend beyond the acute infection phase. This heterogeneous presentation poses substantial challenges for clinical assessment, diagnosis, and treatment planning. In this paper, we focus on imaging findings that may suggest fibrotic damage in the lungs, a critical manifestation characterized by scarring of lung tissue, which can potentially affect long-term respiratory function in patients with PASC. This study introduces a novel multi-center chest CT analysis framework that combines deep learning and radiomics for fibrosis prediction. Our approach leverages convolutional neural networks (CNNs) and interpretable feature extraction, achieving 82.2% accuracy and 85.5% AUC in classification tasks. We demonstrate the effectiveness of Grad-CAM visualization and radiomics-based feature analysis in providing clinically relevant insights for PASC-related lung fibrosis prediction. Our findings highlight the potential of deep learning-driven computational methods for early detection and risk assessment of PASC-related lung fibrosis--presented for the first time in the literature.

Background This study proposes a Vision-Language Model (VLM) leveraging the SIGLIP encoder and Gemma-3b transformer decoder to enhance automated chronic tuberculosis (TB) screening. By integrating chest X-ray images with clinical data, the model addresses the challenges of manual interpretation, improving diagnostic consistency and accessibility, particularly in resource-constrained settings. Methods The VLM architecture combines a Vision Transformer (ViT) for visual encoding and a transformer-based text encoder to process clinical context, such as patient histories and treatment records. Cross-modal attention mechanisms align radiographic features with textual information, while the Gemma-3b decoder generates comprehensive diagnostic reports. The model was pre-trained on 5 million paired medical images and texts and fine-tuned using 100,000 chronic TB-specific chest X-rays. Results The model demonstrated high precision (94 percent) and recall (94 percent) for detecting key chronic TB pathologies, including fibrosis, calcified granulomas, and bronchiectasis. Area Under the Curve (AUC) scores exceeded 0.93, and Intersection over Union (IoU) values were above 0.91, validating its effectiveness in detecting and localizing TB-related abnormalities. Conclusion The VLM offers a robust and scalable solution for automated chronic TB diagnosis, integrating radiographic and clinical data to deliver actionable and context-aware insights. Future work will address subtle pathologies and dataset biases to enhance the model's generalizability, ensuring equitable performance across diverse populations and healthcare settings.

Non-alcoholic fatty liver disease (NAFLD) is one of the most widespread liver disorders on a global scale, posing a significant threat of progressing to more severe conditions like nonalcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma. Diagnosing and staging NAFLD presents challenges due to its non-specific symptoms and the invasive nature of liver biopsies. Our research introduces a novel artificial intelligence cascade model employing ensemble learning and feature fusion techniques. We developed a non-invasive, robust, and reliable diagnostic artificial intelligence tool that utilizes anthropometric and laboratory parameters, facilitating early detection and intervention in NAFLD progression. Our novel artificial intelligence achieved an 86% accuracy rate for the NASH steatosis staging task (non-NASH, steatosis grade 1, steatosis grade 2, and steatosis grade 3) and an impressive 96% AUC-ROC for distinguishing between NASH (steatosis grade 1, grade 2, and grade3) and non-NASH cases, outperforming current state-of-the-art models. This notable improvement in diagnostic performance underscores the potential application of artificial intelligence in the early diagnosis and treatment of NAFLD, leading to better patient outcomes and a reduced healthcare burden associated with advanced liver disease.

Fibrotic Lung Disease (FLD) is a severe condition marked by lung stiffening and scarring, leading to respiratory decline. High-resolution computed tomography (HRCT) is critical for diagnosing and monitoring FLD; however, fibrosis appears as irregular, diffuse patterns with unclear boundaries, leading to high inter-observer variability and time-intensive manual annotation. To tackle this challenge, we propose DiffSeg, a novel weakly supervised semantic segmentation (WSSS) method that uses image-level annotations to generate pixel-level fibrosis segmentation, reducing the need for fine-grained manual labeling. Additionally, our DiffSeg incorporates a diffusion-based generative model to synthesize HRCT images with different levels of fibrosis from healthy slices, enabling the generation of the fibrosis-injected slices and their paired fibrosis location. Experiments indicate that our method significantly improves the accuracy of pseudo masks generated by existing WSSS methods, greatly reducing the complexity of manual labeling and enhancing the consistency of the generated masks.

Airway-related quantitative imaging biomarkers are crucial for examination, diagnosis, and prognosis in pulmonary diseases. However, the manual delineation of airway trees remains prohibitively time-consuming. While significant efforts have been made towards enhancing airway modelling, current public-available datasets concentrate on lung diseases with moderate morphological variations. The intricate honeycombing patterns present in the lung tissues of fibrotic lung disease patients exacerbate the challenges, often leading to various prediction errors. To address this issue, the 'Airway-Informed Quantitative CT Imaging Biomarker for Fibrotic Lung Disease 2023' (AIIB23) competition was organized in conjunction with the official 2023 International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI). The airway structures were meticulously annotated by three experienced radiologists. Competitors were encouraged to develop automatic airway segmentation models with high robustness and generalization abilities, followed by exploring the most correlated QIB of mortality prediction. A training set of 120 high-resolution computerised tomography (HRCT) scans were publicly released with expert annotations and mortality status. The online validation set incorporated 52 HRCT scans from patients with fibrotic lung disease and the offline test set included 140 cases from fibrosis and COVID-19 patients. The results have shown that the capacity of extracting airway trees from patients with fibrotic lung disease could be enhanced by introducing voxel-wise weighted general union loss and continuity loss. In addition to the competitive image biomarkers for prognosis, a strong airway-derived biomarker (Hazard ratio>1.5, p<0.0001) was revealed for survival prognostication compared with existing clinical measurements, clinician assessment and AI-based biomarkers.

The advent of deep learning has significantly propelled the capabilities of automated medical image diagnosis, providing valuable tools and resources in the realm of healthcare and medical diagnostics. This research delves into the development and evaluation of a Deep Residual Convolutional Neural Network (CNN) for the multi-class diagnosis of chest infections, utilizing chest X-ray images. The implemented model, trained and validated on a dataset amalgamated from diverse sources, demonstrated a robust overall accuracy of 93%. However, nuanced disparities in performance across different classes, particularly Fibrosis, underscored the complexity and challenges inherent in automated medical image diagnosis. The insights derived pave the way for future research, focusing on enhancing the model's proficiency in classifying conditions that present more subtle and nuanced visual features in the images, as well as optimizing and refining the model architecture and training process. This paper provides a comprehensive exploration into the development, implementation, and evaluation of the model, offering insights and directions for future research and development in the field.

Objectives: Early detection of liver fibrosis can help cure the disease or prevent disease progression. We perform a comprehensive study of machine learning-based fibrosis detection in CT images using radiomic features to develop a non-invasive approach to fibrosis detection. Methods: Two sets of radiomic features were extracted from spherical ROIs in CT images of 182 patients who underwent simultaneous liver biopsy and CT examinations, one set corresponding to biopsy locations and another distant from biopsy locations. Combinations of contrast, normalization, machine learning model, feature selection method, bin width, and kernel radius were investigated, each of which were trained and evaluated 100 times with randomized development and test cohorts. The best settings were evaluated based on their mean test AUC and the best features were determined based on their frequency among the best settings. Results: Logistic regression models with NC images normalized using Gamma correction with $\gamma = 1.5$ performed best for fibrosis detection. Boruta was the best for radiomic feature selection method. Training a model using these optimal settings and features consisting of first order energy, first order kurtosis, and first order skewness, resulted in a model that achieved mean test AUCs of 0.7549 and 0.7166 on biopsy-based and non-biopsy ROIs respectively, outperforming a baseline and best models found during the initial study. Conclusions: Logistic regression models trained on radiomic features from NC images normalized using Gamma correction with $\gamma = 1.5$ that underwent Boruta feature selection are effective for liver fibrosis detection. Energy, kurtosis, and skewness are particularly effective features for fibrosis detection.

To evaluate the performance of a deep learning (DL) model that measures the liver segmental volume ratio (LSVR) (ie, the volumes of Couinaud segments I–III/IV–VIII) and spleen volumes from CT scans to predict cirrhosis and advanced fibrosis. For this Health Insurance Portability and Accountability Act–compliant, retrospective study, two datasets were used. Dataset 1 consisted of patients with hepatitis C who underwent liver biopsy (METAVIR F0–F4, 2000–2016). Dataset 2 consisted of patients who had cirrhosis from other causes who underwent liver biopsy (Ishak 0–6, 2001–2021). Whole liver, LSVR, and spleen volumes were measured with contrast-enhanced CT by radiologists and the DL model.