A fine-grained account of functional selectivity in the cortex is essential for understanding how visual information is processed and represented in the brain. Classical studies using designed experiments have identified multiple category-selective regions; however, these approaches rely on preconceived hypotheses about categories. Subsequent data-driven discovery methods have sought to address this limitation but are often limited by simple, typically linear encoding models. We propose an in silico approach for data-driven discovery of novel category-selectivity hypotheses based on an encoder-decoder transformer model. The architecture incorporates a brain-region to image-feature cross-attention mechanism, enabling nonlinear mappings between high-dimensional deep network features and semantic patterns encoded in the brain activity. We further introduce a method to characterize the selectivity of individual parcels by leveraging diffusion-based image generative models and large-scale datasets to synthesize and select images that maximally activate each parcel. Our approach reveals regions with complex, compositional selectivity involving diverse semantic concepts, which we validate in silico both within and across subjects. Using a brain encoder as a "digital twin" offers a powerful, data-driven framework for generating and testing hypotheses about visual selectivity in the human brain--hypotheses that can guide future fMRI experiments.

Imaging systems have traditionally been designed to mimic the human eye and produce visually interpretable measurements.

It is observed that the confidence score may fail to reflect the predicting quality accurately in previous proposal-based line segment detection methods, since the scores and the line locations are predicted simultaneously. We find that the line segment detection performance can be further improved by learning-based line candidate ranking and optimizing strategy. To this end, we build a novel end-to-end line detecting model named RANK++LETR upon deformable DETR architecture, where the encoder is used to select the line candidates while the decoder is applied to rank and optimize these candidates. We design line-aware deformable attention (LADA) module in which attention positions are distributed in a long narrow area and can align well with the elongated geometry of line segments. Moreover, we innovatively apply ranking-based supervision in line segment detection task with the design of contiguous labels according to the detection quality. Experimental results demonstrate that our method outperforms previous SOTA methods in prediction accuracy and gets faster inferring speed than other Transformer-based methods.

Attention-based encoder decoder models remain a popular choice for state-of-the-art automatic speech recognition (ASR). These models combine a powerful audio encoder that extracts rich acoustic features with a decoder that autoregressively produces the ASR output. The decoder handles two critical tasks: (1) building rich text-only context and (2) merging acoustic information from the encoder to ensure the predictions remain faithful to the audio. We observe a systematic pattern across the attention distributions of decoder layers in prior architectures: the initial layers direct most attention towards building textual context, while the later layers largely focus on merging acoustic and textual information for the final predictions. Leveraging this key insight, we propose BLOCKDECODER, a novel decoder architecture comprising two distinct components: a text encoder that is purely text-based, and a MERGER that combines information from the audio encoder and text encoder to generate output tokens. Unlike traditional decoders, the MERGER autoregressively predicts a sequence of K tokens within a block of size K, while relying on the same precomputed contextual information from both text and audio encoders across the block. This design choice allows for the efficient reuse of encoder representations. The separation of the decoder into the text encoder and the MERGER promotes modularity and more flexible control of parameters via the number of text encoder and MERGER layers. As a result, BLOCKDECODER yields a significant speedup ( 2x) compared to traditional decoders, across diverse datasets, languages, and speech tasks, without any degradation in performance.

The scarcity of annotated medical imaging data has driven significant progress in semi-supervised learning to alleviate reliance on expensive expert labeling. While foundational vision models such as the Segment Anything Model (SAM) exhibit robust generalization in generic segmentation tasks, their direct application to medical images often results in suboptimal performance. To address this challenge, in this work, we propose a novel fully SAM-based semi-supervised medical image segmentation framework and develop the corresponding knowledge distillationbased learning strategy. Specifically, we first employ an efficient SAM variant as the backbone network of the semi-supervised framework and update the default prompt embedding of SAM to unleash its full potential. Then, we utilize an original SAM, which is rich in prior knowledge, as the teacher to optimize our efficient student SAM backbone through hierarchical knowledge distillation and a dynamic loss weighting strategy. Extensive experiments on various medical datasets demonstrate that our method outperforms state-of-the-art semi-supervised segmentation approaches. Especially, our model requires less than 10% of the parameter size of the original SAM, enabling substantially lower deployment and storage overhead in real-world clinical settings.

Integrating ground-level geospatial data with rich geographic context, like OpenStreetMap (OSM), into remote sensing (RS) foundation models (FMs) is essential for advancing geospatial intelligence and supporting a broad spectrum of tasks. However, modality gap between RS and OSM data, including differences in data structure, content, and spatial granularity, makes effective synergy highly challenging, and most existing RSFMs focus on imagery alone. To this end, this study presents GeoLink, a multimodal framework that leverages OSM data to enhance RSFM during both the pretraining and downstream task stages. Specifically, GeoLink enhances RS self-supervised pretraining using multi-granularity learning signals derived from OSM data, guided by cross-modal spatial correlations for information interaction and collaboration. It also introduces image maskreconstruction to enable sparse input for efficient pretraining. For downstream tasks, GeoLink generates both unimodal and multimodal fine-grained encodings to support a wide range of applications, from common RS interpretation tasks like land cover classification to more comprehensive geographic tasks like urban function zone mapping. Extensive experiments show that incorporating OSM data during pretraining enhances the performance of the RS image encoder, while fusing RS and OSM data in downstream tasks improves the FM's adaptability to complex geographic scenarios. These results underscore the potential of multimodal synergy in advancing high-level geospatial artificial intelligence. Moreover, we find that spatial correlation plays a crucial role in enabling effective multimodal geospatial data integration.

Multimodal contrastive learning models (e.g., CLIP) can learn high-quality representations from large-scale image-text datasets, while they exhibit significant vulnerabilities to backdoor attacks, raising serious safety concerns. In this paper, we reveal that CLIP's vulnerabilities primarily stem from its tendency to encode features beyond in-dataset predictive patterns, compromising its visual feature resistivity to input perturbations. This makes its encoded features highly susceptible to being reshaped by backdoor triggers. To address this challenge, we propose Repulsive Visual Prompt Tuning (RVPT), a novel defense approach that employs deep visual prompt tuning with a specially designed feature-repelling loss. Specifically, RVPT adversarially repels the encoded features from deeper layers while optimizing the standard cross-entropy loss, ensuring that only predictive features in downstream tasks are encoded, thereby enhancing CLIP's visual feature resistivity against input perturbations and mitigating its susceptibility to backdoor attacks. Unlike existing multimodal backdoor defense methods that typically require the availability of poisoned data or involve fine-tuning the entire model, RVPT leverages few-shot downstream clean samples and only tunes a small number of parameters. Empirical results demonstrate that RVPT tunes only 0.27% of the parameters in CLIP, yet it significantly outperforms state-of-the-art defense methods, reducing the attack success rate from 89.70% to 2.76% against the most advanced multimodal attacks on ImageNet and effectively generalizes its defensive capabilities across multiple datasets. The code is publicly available in our GitHub repository: https://github.com/zhangzf01/RVPT.

Multimodal learning holds promise for richer information extraction by capturing dependencies across data sources. Yet, current training methods often underperform due to modality competition, a phenomenon where modalities contend for training resources leaving some underoptimized. This raises a pivotal question: how can we address training imbalances, ensure adequate optimization across all modalities, and achieve consistent performance improvements as we transition from unimodal to multimodal data? This paper proposes the Multimodal Competition Regularizer (MCR), inspired by a mutual information (MI) decomposition designed to prevent the adverse effects of competition in multimodal training. Our key contributions are: 1) A game-theoretic framework that adaptively balances modality contributions by encouraging each to maximize its informative role in the final prediction 2) Refining lower and upper bounds for each MI term to enhance the extraction of both taskrelevant unique and shared information across modalities.

Task-specific pre-training is essential when task representations diverge from generic pre-training features.

Pre-trained encoders for offline feature extraction followed by multiple instance learning (MIL) aggregators have become the dominant paradigm in computational pathology (CPath), benefiting cancer diagnosis and prognosis. However, performance limitations arise from the absence of encoder fine-tuning for downstream tasks and disjoint optimization with MIL. While slide-level supervised end-to-end (E2E) learning is an intuitive solution to this issue, it faces challenges such as high computational demands and suboptimal results. These limitations motivate us to revisit E2E learning. We argue that prior work neglects inherent E2E optimization challenges, leading to performance disparities compared to traditional two-stage methods. In this paper, we pioneer the elucidation of optimization challenge caused by sparse-attention MIL and propose a novel MIL called ABMILX.