In the era of AI-driven science and engineering, we often want to design discrete objects in silico according to user-specified properties. For example, we may wish to design a protein to bind its target, arrange components within a circuit to minimize latency, or find materials with certain properties. Given a property predictive model, in silico design typically involves training a generative model over the design space (e.g., protein sequence space) to concentrate on designs with the desired properties. Distributional optimization -- which can be formalized as an estimation of distribution algorithm or as reinforcement learning policy optimization -- finds the generative model that maximizes an objective function in expectation. Optimizing a distribution over discrete-valued designs is in general challenging because of the combinatorial nature of the design space. However, many property predictors in scientific applications are decomposable in the sense that they can be factorized over design variables in a way that could in principle enable more effective optimization. For example, amino acids at a catalytic site of a protein may only loosely interact with amino acids of the rest of the protein to achieve maximal catalytic activity. Current distributional optimization algorithms are unable to make use of such decomposability structure. Herein, we propose and demonstrate use of a new distributional optimization algorithm, Decomposition-Aware Distributional Optimization (DADO), that can leverage any decomposability defined by a junction tree on the design variables, to make optimization more efficient. At its core, DADO employs a soft-factorized "search distribution" -- a learned generative model -- for efficient navigation of the search space, invoking graph message-passing to coordinate optimization across linked factors.

Electrodermal activity (EDA), the primary signal for stress detection, requires costly hardware often unavailable in real-world wearables. In this paper, we propose PULSE, a framework that utilizes EDA exclusively during self-supervised pretraining, while enabling inference without EDA but with more readily available modalities such as ECG, BVP, ACC, and TEMP. Our approach separates encoder outputs into shared and private embeddings. We align "shared" embeddings across modalities and fuse them into a modality-invariant representation. The "private" embeddings carry modality-specific information to support the reconstruction objective. Pretraining is followed by knowledge transfer where a frozen EDA teacher transfers sympathetic-arousal representations into student encoders. On WESAD, our method achieves strong stress-detection performance, showing that representations of privileged EDA can be transferred to low-cost sensors to improve accuracy while reducing hardware cost.

To leverage this dataset, we introduced the Contrastive Language Signal Pre-training (CLSP) method, which jointly learns representations using pairs of physiological signals and textual descriptions.

To leverage this dataset, we introduced the Contrastive Language Signal Pre-training (CLSP) method, which jointly learns representations using pairs of physiological signals and textual descriptions.

Recent breakthroughs in Large Language Models (LLMs) and Large Circuit Models (LCMs) have sparked excitement across the electronic design automation (EDA) community, promising a revolution in circuit design and optimization. Yet, this excitement is met with significant skepticism: Are these AI models a genuine revolution in circuit design, or a temporary wave of inflated expectations? This paper serves as a foundational text for the corresponding ICCAD 2025 panel, bringing together perspectives from leading experts in academia and industry. It critically examines the practical capabilities, fundamental limitations, and future prospects of large AI models in hardware design. The paper synthesizes the core arguments surrounding reliability, scalability, and interpretability, framing the debate on whether these models can meaningfully outperform or complement traditional EDA methods. The result is an authoritative overview offering fresh insights into one of today's most contentious and impactful technology trends.

With the growing complexity of modern integrated circuits, hardware engineers are required to devote more effort to the full design-to-manufacturing workflow. This workflow involves numerous iterations, making it both labor-intensive and error-prone. Therefore, there is an urgent demand for more efficient Electronic Design Automation (EDA) solutions to accelerate hardware development. Recently, large language models (LLMs) have shown remarkable advancements in contextual comprehension, logical reasoning, and generative capabilities. Since hardware designs and intermediate scripts can be represented as text, integrating LLM for EDA offers a promising opportunity to simplify and even automate the entire workflow. Accordingly, this paper provides a comprehensive overview of incorporating LLMs into EDA, with emphasis on their capabilities, limitations, and future opportunities. Three case studies, along with their outlook, are introduced to demonstrate the capabilities of LLMs in hardware design, testing, and optimization. Finally, future directions and challenges are highlighted to further explore the potential of LLMs in shaping the next-generation EDA, providing valuable insights for researchers interested in leveraging advanced AI technologies for EDA.

We address your concerns as follows. Comparison of settings in related work. We add DANN+EWC and DANN+GEM in Table 3. We will elaborate on continual/incremental learning literature in the revision. See the comparison of these settings in Table 1.

EDM elucidates the unified design space of diffusion models, yet its fixed noise patterns restricted to pure Gaussian noise, limit advancements in image restoration. Our study indicates that forcibly injecting Gaussian noise corrupts the degraded images, overextends the image transformation distance, and increases restoration complexity. To address this problem, our proposed EDA Elucidates the Design space of Arbitrary-noise-based diffusion models. Theoretically, EDA expands the freedom of noise pattern while preserving the original module flexibility of EDM, with rigorous proof that increased noise complexity incurs no additional computational overhead during restoration. EDA is validated on three typical tasks: MRI bias field correction (global smooth noise), CT metal artifact reduction (global sharp noise), and natural image shadow removal (local boundary-aware noise). With only 5 sampling steps, EDA outperforms most task-specific methods and achieves state-of-the-art performance in bias field correction and shadow removal.

Accurately detecting drowsiness is vital to driving safety. Among all measures, physiological-signal-based drowsiness monitoring can be more privacy-preserving than a camera-based approach. However, conflicts exist regarding how physiological metrics are associated with different drowsiness labels across datasets. Thus, we analyzed key features from electrocardiograms (ECG), electrodermal activity (EDA), and respiratory (RESP) signals across four datasets, where different drowsiness inducers (such as fatigue and low arousal) and assessment methods (subjective vs. objective) were used. Binary logistic regression models were built to identify the physiological metrics that are associated with drowsiness. Findings indicate that distinct different drowsiness inducers can lead to different physiological responses, and objective assessments were more sensitive than subjective ones in detecting drowsiness. Further, the increased heart rate stability, reduced respiratory amplitude, and decreased tonic EDA are robustly associated with increased drowsiness. The results enhance understanding of drowsiness detection and can inform future generalizable monitoring designs.