Neural Information Processing Systems http://nips.cc/

Existing approaches rely on various local heuristics for enforcing the acyclicity constraint.

The end-cut preference (ECP) problem, referring to the tendency to favor split points near the boundaries of a feature's range, is a well-known issue in CART (Breiman et al., 1984). ECP may induce highly imbalanced and biased splits, obscure weak signals, and lead to tree structures that are both unstable and difficult to interpret. For survival trees, we show that ECP also arises when using greedy search to select the optimal cutoff point by maximizing the log-rank test statistic. To address this issue, we propose a smooth sigmoid surrogate (SSS) approach, in which the hard-threshold indicator function is replaced by a smooth sigmoid function. We further demonstrate, both theoretically and through numerical illustrations, that SSS provides an effective remedy for mitigating or avoiding ECP.

Machine learning has been widely used to optimize complex engineering workflows across numerous domains. In the context of integrated circuit design, modern flows (e.g., going from a register-transfer level netlist to physical layouts) involve extensive configuration via thousands of parameters, and small changes to these parameters can have large downstream impacts on desired outcomes - namely design performance, power, and area. Recent advances in Large Language Models (LLMs) offer new opportunities for learning and reasoning within such high-dimensional optimization tasks. In this work, we introduce ORFS-agent, an LLM-based iterative optimization agent that automates parameter tuning in an open-source hardware design flow. ORFS-agent adaptively explores parameter configurations, demonstrating clear improvements over standard Bayesian optimization approaches in terms of resource efficiency and final design metrics. Our empirical evaluations on two different technology nodes and a range of circuit benchmarks indicate that ORFS-agent can improve both routed wirelength and effective clock period by over 13%, all while using 40% fewer optimization iterations. Moreover, by following natural language objectives to trade off certain metrics for others, ORFS-agent demonstrates a flexible and interpretable framework for multi-objective optimization. Crucially, RFS-agent is modular and model-agnostic, and can be plugged in to any frontier LLM without any further fine-tuning.

Funding The study was supported by the Start - up Fund for RAPs under the Strategic Hiring Scheme (P0048623) from HKSAR, the Global STEM Professorship Scheme (P0046113) and Henry G. Leong Endowed Professorship in Elderly Vision Health. 2 Abstract Large language models (LLMs) show promise for tailored healthcare communication but face challenges in interpretability and multi - task integration particularly for domain - specific needs like myopia, a nd their real - world effectiveness as patient education tools has yet to be demonstrated . Here, we introduce ChatMyopia, an LLM - based AI agent designed to address text and image - based inquiries related to myopia. To achieve this, ChatMyopia integrates an image classification tool and a retrieval - augmented knowledge base built from literature, expert consensus, and clinical guidelines. M yopic maculopathy grading task, single question examination and human evaluations validated its ability to deliver personalized, accurate, and safe responses to myopia - related inquirie s with high scalability and interpretability . In a randomized controlled trial (n=70, NCT06607822), ChatMyopia significantly improved patient satisfaction compared to traditional leaflets, enhancing patient education in accuracy, empathy, disease awareness, and patient - eye care practitioner communication. These findings highlight ChatMyopia ' s potential as a valuable supplement to enhance patient education and improve satisfaction with medical services in primary eye care settings . Keywords: Large language model, Medical a gent, Myopia, Patient education, Randomized controlled trial. Introduction For patients, a lack of basic understanding of their condition before initial consultations can hinder communication, as clinicians may spend time explaining fundamental concepts instead of critical issues, resulting in poor decisions and noncompliance [1, 2] . Therefore, patients require professional information and support to enhance their healthcare experiences.

Optimizing expensive, non-convex, black-box Lipschitz continuous functions presents significant challenges, particularly when the Lipschitz constant of the underlying function is unknown. Such problems often demand numerous function evaluations to approximate the global optimum, which can be prohibitive in terms of time, energy, or resources. In this work, we introduce Every Call is Precious (ECP), a novel global optimization algorithm that minimizes unpromising evaluations by strategically focusing on potentially optimal regions. Unlike previous approaches, ECP eliminates the need to estimate the Lipschitz constant, thereby avoiding additional function evaluations. ECP guarantees no-regret performance for infinite evaluation budgets and achieves minimax-optimal regret bounds within finite budgets. Extensive ablation studies validate the algorithm's robustness, while empirical evaluations show that ECP outperforms 10 benchmark algorithms including Lipschitz, Bayesian, bandits, and evolutionary methods across 30 multi-dimensional non-convex synthetic and real-world optimization problems, which positions ECP as a competitive approach for global optimization.

Increased usage of automated tools like deep learning in medical image segmentation has alleviated the bottleneck of manual contouring. This has shifted manual labour to quality assessment (QA) of automated contours which involves detecting errors and correcting them. A potential solution to semi-automated QA is to use deep Bayesian uncertainty to recommend potentially erroneous regions, thus reducing time spent on error detection. Previous work has investigated the correspondence between uncertainty and error, however, no work has been done on improving the "utility" of Bayesian uncertainty maps such that it is only present in inaccurate regions and not in the accurate ones. Our work trains the FlipOut model with the Accuracy-vs-Uncertainty (AvU) loss which promotes uncertainty to be present only in inaccurate regions. We apply this method on datasets of two radiotherapy body sites, c.f. head-and-neck CT and prostate MR scans. Uncertainty heatmaps (i.e. predictive entropy) are evaluated against voxel inaccuracies using Receiver Operating Characteristic (ROC) and Precision-Recall (PR) curves. Numerical results show that when compared to the Bayesian baseline the proposed method successfully suppresses uncertainty for accurate voxels, with similar presence of uncertainty for inaccurate voxels. Code to reproduce experiments is available at https://github.com/prerakmody/bayesuncertainty-error-correspondence

In this paper, we propose Evidential Conformal Prediction (ECP) method for image classifiers to generate the conformal prediction sets. Our method is designed based on a non-conformity score function that has its roots in Evidential Deep Learning (EDL) as a method of quantifying model (epistemic) uncertainty in DNN classifiers. We use evidence that are derived from the logit values of target labels to compute the components of our non-conformity score function: the heuristic notion of uncertainty in CP, uncertainty surprisal, and expected utility. Our extensive experimental evaluation demonstrates that ECP outperforms three state-of-the-art methods for generating CP sets, in terms of their set sizes and adaptivity while maintaining the coverage of true labels.

The study of causal relationships between emotions and causes in texts has recently received much attention. Most works focus on extracting causally related clauses from documents. However, none of these works has considered that the causal relationships among the extracted emotion and cause clauses can only be valid under some specific context clauses. To highlight the context in such special causal relationships, we propose a new task to determine whether or not an input pair of emotion and cause has a valid causal relationship under different contexts and extract the specific context clauses that participate in the causal relationship. Since the task is new for which no existing dataset is available, we conduct manual annotation on a benchmark dataset to obtain the labels for our tasks and the annotations of each context clause's type that can also be used in some other applications. We adopt negative sampling to construct the final dataset to balance the number of documents with and without causal relationships. Based on the constructed dataset, we propose an end-to-end multi-task framework, where we design two novel and general modules to handle the two goals of our task. Specifically, we propose a context masking module to extract the context clauses participating in the causal relationships. We propose a prediction aggregation module to fine-tune the prediction results according to whether the input emotion and causes depend on specific context clauses. Results of extensive comparative experiments and ablation studies demonstrate the effectiveness and generality of our proposed framework.

Tools of Topological Data Analysis provide stable summaries encapsulating the shape of the considered data. Persistent homology, the most standard and well studied data summary, suffers a number of limitations; its computations are hard to distribute, it is hard to generalize to multifiltrations and is computationally prohibitive for big data-sets. In this paper we study the concept of Euler Characteristics Curves, for one parameter filtrations and Euler Characteristic Profiles, for multi-parameter filtrations. While being a weaker invariant in one dimension, we show that Euler Characteristic based approaches do not possess some handicaps of persistent homology; we show efficient algorithms to compute them in a distributed way, their generalization to multifiltrations and practical applicability for big data problems. In addition we show that the Euler Curves and Profiles enjoys certain type of stability which makes them robust tool in data analysis. Lastly, to show their practical applicability, multiple use-cases are considered.