Science sleuths think they found Leonardo da Vinci's DNA Advances in genetics might help us see what set the Renaissance man apart. The painting hangs in the Uffizi Gallery in Florence, Italy. Breakthroughs, discoveries, and DIY tips sent every weekday. Scientists are one step closer to pinpointing fragments of Leonardo da Vinci's elusive DNA . A team of researchers from the Leonardo da Vinci DNA Project analyzed samples swabbed from a red chalk drawing possibly attributed to the famed polymath, as well as letters written by one of his known cousins.

Modeling these sequences is key to understand disease mechanisms and is an active research area in computational biology. Recently, Large Language Models have shown great promise in solving certain biological tasks but current approaches are limited to a single sequence modality (DNA, RNA, or protein). Key problems in genomics intrinsically involve multiple modalities, but it remains unclear how to adapt general-purpose sequence models to those cases. In this work we propose a multi-modal model that connects DNA, RNA, and proteins by leveraging information from different pre-trained modality-specific encoders. We demonstrate its capabilities by applying it to the largely unsolved problem of predicting how multiple \rna transcript isoforms originate from the same gene (i.e.

Centuries-old genetic material can solve historical mysteries, from lost species to what killed Napoleon's army. A glowing, digital double helix represents the billions of base pairs scientists analyze when sequencing ancient DNA. Breakthroughs, discoveries, and DIY tips sent every weekday. In 1976, workers excavating a tunnel for the Toronto subway system came across some very old bones. Using radiocarbon dating, researchers determined the partial cranium and fragments of antlers were roughly 12,000 years old.

In this paper, we first revisit the application of differentiable neural architecture search (DNAS) methods to circuit generation and found from extensive experiments that existing DNAS methods struggle to exactly generate circuits, scale poorly to large circuits, and exhibit high sensitivity to hyper-parameters. Then we provide three major insights for these challenges from extensive empirical analysis: 1) DNAS tends to overfit to too many skip-connections, consequently wasting a significant portion of the network's expressive capabilities; 2) DNAS suffers from the structure bias between the network architecture and the circuit

Instead, we show that learning these tasks independently, but with a constrained distillation phase, significantly improves performance. Furthermore, we find that policy gradient noise levels decrease when using a lower variance return estimate.

Fine-grained zero-shot learning task requires some form of side-information to transfer discriminative information from seen to unseen classes.

In February 1953, two men walked into a pub in Cambridge and announced they had found the secret of life. It was not an idle boast. One was James Watson, an American biologist from the Cavendish laboratory; the other was his British research partner, Francis Crick. The full Promethean power of their achievement would slowly emerge over decades of research by fellow geneticists. It also opened a Pandora's Box of controversial scientific and ethical issues - including human cloning, designer babies and Frankenstein foods.

Yes, you can pay $50,000 to clone a pet. But others are using the technology to rescue endangered species. This week, we heard that Tom Brady had his dog cloned. The former quarterback revealed that his Junie is actually a clone of Lua, a pit bull mix that died in 2023. Brady's announcement follows those of celebrities like Paris Hilton and Barbra Streisand, who also famously cloned their pet dogs. But some believe there are better ways to make use of cloning technologies.

Breakthroughs, discoveries, and DIY tips sent every weekday. It's a really big deal when fossilized feces survive the ravages of time. These hardened pieces of excrement open up a window into what animals ate thousands of years ago and even what may have made them sick . Humans are not exempt from this, with dried human feces indicating we have always loved cheese and beer and that our microbiome has evolved over thousands of years. DNA recovered from 1,000-year-old dried feces indicates that intestinal infections from pinworm or Shingella may have plagued ancient people living in present day northern Mexico's Rio Zape Valley.