A baby with a rare neurological disorder, airlifted to hospital after collapsing in a supermarket, is not out of the woods yet, said his father. Seven-month-old Rupert Smith, from Broughton, Flintshire, stopped breathing in a Tesco store in Broughton Park, on Monday. His mother Siobhan, 35, immediately called for help and administered CPR before emergency services, including paramedics, police and an air ambulance arrived. Rupert, who has a disorder called alternating hemiplegia of childhood (AHC), was flown to Alder Hey Children's Hospital in Liverpool for treatment. Dad Dave Smith said Rupert had continued to have quite significant seizures [in hospital] so they have been giving him medication and he has undergone various different tests.

Why personalized gene editing, genetic resurrections and embryo scoring made our list. Earlier this week, published its annual list of Ten Breakthrough Technologies. As always, it features technologies that made the news last year, and which--for better or worse--stand to make waves in the coming years. They're the technologies you should really be paying attention to. This year's list includes tech that's set to transform the energy industry, artificial intelligence, space travel --and of course biotech and health. Our breakthrough biotechnologies for 2026 involve editing a baby's genes and, separately, resurrecting genes from ancient species.

"It seems like this past week has been quite challenging for you," a disembodied voice tells me, before proceeding to ask a series of increasingly personal questions. "Have you been feeling down or depressed?" "Can you describe what this feeling has been like for you?" "Does the feeling lift at all when something good happens?" When I respond to each one, my chatbot interviewer thanks me for my honesty and empathises with any issues. By the end of the conversation, I will have also spoken about my sleep patterns, sex drive and appetite for food.

We study the free energy for pure and mixed spherical $p$-spin models with i.i.d.\ disorder. In the mixed case, each $p$-interaction layer is assumed either to have regularly varying tails with exponent $α_p$ or to satisfy a finite $2p$-th moment condition. For the pure spherical $p$-spin model with regularly varying disorder of tail index $α$, we introduce a tail-adapted normalization that interpolates between the classical Gaussian scaling and the extreme-value scale, and we prove a sharp universality dichotomy for the quenched free energy. In the subcritical regime $α<2p$, the thermodynamics is driven by finitely many extremal couplings and the free energy converges to a non-degenerate random limit described by the NIM (non-intersecting monomial) model, depending only on extreme-order statistics. At the critical exponent $α=2p$, we obtain a random one-dimensional TAP-type variational formula capturing the coexistence of an extremal spike and a universal Gaussian bulk on spherical slices. In the supercritical regime $α>2p$ (more generally, under a finite $2p$-th moment assumption), the free energy is universal and agrees with the deterministic Crisanti--Sommers/Parisi value of the corresponding Gaussian model, as established in [Sawhney-Sellke'24]. We then extend the subcritical and critical results to mixed spherical models in which each $p$-layer is either heavy-tailed with $α_p\le 2p$ or has finite $2p$-th moment. In particular, we derive a TAP-type variational representation for the mixed model, yielding a unified universality classification of the quenched free energy across tail exponents and mixtures.

Biological neural networks face a formidable task: performing reliable computations in the face of intrinsic stochasticity in individual neurons, imprecisely specified synaptic connectivity, and nonnegligible delays in synaptic transmission. A common approach to combatting such biological heterogeneity involves averaging over large redundant networks of N neurons resulting in coding errors that decrease classically as the square root of N. Recent work demonstrated a novel mechanism whereby recurrent spiking networks could efficiently encode dynamic stimuli achieving a superclassical scaling in which coding errors decrease as 1/N. This specific mechanism involved two key ideas: predictive coding, and a tight balance, or cancellation between strong feedforward inputs and strong recurrent feedback. However, the theoretical principles governing the efficacy of balanced predictive coding and its robustness to noise, synaptic weight heterogeneity and communication delays remain poorly understood. To discover such principles, we introduce an analytically tractable model of balanced predictive coding, in which the degree of balance and the degree of weight disorder can be dissociated unlike in previous balanced network models, and we develop a mean-field theory of coding accuracy. Overall, our work provides and solves a general theoretical framework for dissecting the differential contributions neural noise, synaptic disorder, chaos, synaptic delays, and balance to the fidelity of predictive neural codes, reveals the fundamental role that balance plays in achieving superclassical scaling, and unifies previously disparate models in theoretical neuroscience.

With the rapid advancement of conversational and diffusion-based AI, there is a growing adoption of AI in educational services, ranging from grading and assessment tools to personalized learning systems that provide targeted support for students. However, this adaptability has yet to fully extend to the domain of children's speech, where existing models often fail due to their reliance on datasets designed for clear, articulate adult speech. Children, particularly those in early developmental stages or with speech and language pathologies, present unique challenges that current AI models and datasets are ill-equipped to handle. To address this, we introduce KidSpeak, a multi-task speech-enhanced Foundation Model capable of both generative and discriminative tasks specifically tailored to children's speech patterns. Our framework employs a two-stage training process that incorporates phonetic knowledge into the speech encoder, achieving an average accuracy of 87% across four separate tasks. Furthermore, recognizing the limitations of scalable human annotation and existing speech alignment tools, we propose the Flexible and Automatic Speech Aligner (F ASA) and leverage the method to construct high quality datasets for training and evaluation. This novel alignment tool significantly improves the quality of aligned children's speech from noisy data, enhancing data quality by 13.6 compared to human annotations, as demonstrated on the CHILDES dataset. To the best of our knowledge, KidSpeak and F ASA represent the first comprehensive solution designed for speech and language therapy in children, offering both a multi-purpose speech LLM and a robust alignment tool.

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition whose rising prevalence places increasing demands on a lengthy diagnostic process. Machine learning (ML) has shown promise in automating ASD diagnosis, but most existing models operate as black boxes and are typically trained on a single dataset, limiting their generalizability. In this study, we introduce a transparent and interpretable ML approach that leverages BioBERT, a state-of-the-art language model, to analyze unstructured clinical text. The model is trained to label descriptions of behaviors and map them to diagnostic criteria, which are then used to assign a final label (ASD or not). We evaluate transfer learning, the ability to transfer knowledge to new data, using two distinct real-world datasets. We trained on datasets sequentially and mixed together and compared the performance of the best models and their ability to transfer to new data. We also created a black-box approach and repeated this transfer process for comparison. Our transparent model demonstrated robust performance, with the mixed-data training strategy yielding the best results (97 % sensitivity, 98 % specificity). Sequential training across datasets led to a slight drop in performance, highlighting the importance of training data order. The black-box model performed worse (90 % sensitivity, 96 % specificity) when trained sequentially or with mixed data. Overall, our transparent approach outperformed the black-box approach. Mixing datasets during training resulted in slightly better performance and should be the preferred approach when practically possible. This work paves the way for more trustworthy, generalizable, and clinically actionable AI tools in neurodevelopmental diagnostics.

Phase classification has become a prototypical benchmark for data-driven analysis of condensed matter physics. The type and complexity of the phase transition dictate the level of complexity of the algorithm one has to employ. This topic has been broadly explored, offering a menu of both supervised and unsupervised techniques ranging from simple clustering [1-3] to more complex machine learning methods [4-7]. The phase classification problem is most commonly posed like so: we allow our model to view a dataset that is both relevant and straightforwardly obtainable in the scenario we wish to study. We introduce this data set to a model that has no prior knowledge of underlying physics.

Generative AI systems may pose serious risks to individuals vulnerable to eating disorders. Existing safeguards tend to overlook subtle but clinically significant cues, leaving many risks unaddressed. To better understand the nature of these risks, we conducted semi-structured interviews with 15 clinicians, researchers, and advocates with expertise in eating disorders. Using abductive qualitative analysis, we developed an expert-guided taxonomy of generative AI risks across seven categories: (1) providing generalized health advice; (2) encouraging disordered behaviors; (3) supporting symptom concealment; (4) creating thinspiration; (5) reinforcing negative self-beliefs; (6) promoting excessive focus on the body; and (7) perpetuating narrow views about eating disorders. Our results demonstrate how certain user interactions with generative AI systems intersect with clinical features of eating disorders in ways that may intensify risk. We discuss implications of our work, including approaches for risk assessment, safeguard design, and participatory evaluation practices with domain experts.

This work presents the development and evaluation of an NLP-enabled probabilistic classifier designed to estimate the probability of technical and regulatory success (pTRS) for clinical trials in the field of neuroscience. While pharmaceutical R&D is plagued by high attrition rates and enormous costs, particularly within neuroscience, where success rates are below 10%, timely identification of promising programs can streamline resource allocation and reduce financial risk. Leveraging data from the ClinicalTrials.gov database and success labels from the recently developed Clinical Trial Outcome dataset, the classifier extracts text-based clinical trial features using statistical NLP techniques. These features were integrated into several non-LLM frameworks (logistic regression, gradient boosting, and random forest) to generate calibrated probability scores. Model performance was assessed on a retrospective dataset of 101,145 completed clinical trials spanning 1976-2024, achieving an overall ROC-AUC of 0.64. An LLM-based predictive model was then built using BioBERT, a domain-specific language representation encoder. The BioBERT-based model achieved an overall ROC-AUC of 0.74 and a Brier Score of 0.185, indicating its predictions had, on average, 40% less squared error than would be observed using industry benchmarks. The BioBERT-based model also made trial outcome predictions that were superior to benchmark values 70% of the time overall. By integrating NLP-driven insights into drug development decision-making, this work aims to enhance strategic planning and optimize investment allocation in neuroscience programs.