Large-scale hypothesis testing is central to modern science, where controlling the False Discovery Rate (FDR) has become the standard approach to managing false positives across many simultaneous tests. Hypotheses rarely exist in isolation; they often exhibit structure through proximity, connectivity, or hierarchy. This structure represents both a challenge and an opportunity: while classical methods treat these dependencies as obstacles requiring conservative correction, leveraging them can substantially increase discovery power. Here, we reframe structured FDR control as a regularized learning problem. By optimizing within a suitable Reproducing Kernel Hilbert Space (RKHS), we introduce a framework that unifies continuous domains, graphs, and hierarchies under a single algorithm through kernel choice alone. This formulation enables smooth solutions in place of the piecewise-constant fits of prior methods, principled likelihood-based hyperparameter selection rather than heuristic tuning, and inference at unobserved locations which in turn supports sample-efficient experimental design. Building on this estimator, we provide two decision rules which we prove to control the FDR. We validate our method on two sources: spatial locations derived from high-dimensional real-world datasets, and a differential gene expression task utilizing protein-protein interaction graphs.

In the supplementary material, we provide additional information and details in A.1. This section covers the introduction of data, key parameter settings, comparisons with baselines, optimization methods, and the algorithm process of our method. Furthermore, A.2 presents supplementary experiments for our model, including visualization experiments and replication studies. Additionally, we discuss the reasons behind utilizing hypergraphs as the temporal encoder in A.3. Finally, the limitations and broader impacts of our work are discussed in A.4. A.1 Data and Implementation Details Data. The statistical information of the aforementioned four real-world datasets is presented in Table 4.

Symbol Description Vt Set of observable variables at time t V0:TUnion of observable variables at time t= 0,...,T Xt Manipulative variables at time t Yt Target variable at time t P(Xt) Power set of Xt Mt Set of MIS sets at time t Xs,ts-th intervention set at time t In this section we give the proof for Theorem 1 in the main text. This means that W includes those variables that are parents of Yt but are nor target at previous time steps nor intervened variables. In the following proof the values of IV0:t 1, XPYs,t, IPY0:t 1 and W are denoted by i, xPY, iPY and w respectively. Finally, fYY and fNYYare the functions in the SCM for Yt (see Assumptions (1) in the main text). Eq. (2) follows from the Eq. Finally, noticing that p(yPTt |I0:t 1) is the distribution targeted when optimizing the objective function at previous time steps one can obtain Eq. (6). The derivations above show how the objective function at time t is given by the expected value of the output of the functional relationship fNYYwhere the expectation is taken with respect to the variables that are not intervened on. This expectation is then shifted to account for the interventions implemented in the system at previous time steps that are affecting the target variable through fYY .

Figure 10: A visualization of the layouts and unsupervised depth maps produced by GANformer2's planning stage while synthesizing varied images, making the generative process more structured and interpretable. GANformer2 creates the layout sequentially, segment-by-segment, to capture the scene's compositionality, effectively allowing us to add or remove objects from the resulting images. Since GANformer2 creates each scene as a composition of interacting segments, it supports adding and removal of objects while respecting various dependencies with their surroundings: Amodal completion of occluded objects is denoted by pink, updates of shadows and especially reflections by cyan, and other object removals cases by yellow. Shape manipulation is denoted by green, while position changes by yellow. Color manipulation is denoted by pink, while updates of material by cyan.

The pre-trained language model (PrLM) demonstrates domination in downstream natural language processing tasks, in which multilingual PrLM takes advantage of language universality to alleviate the issue of limited resources for low-resource languages. Despite its successes, the performance of multilingual PrLM is still unsatisfactory, when multilingual PrLMs only focus on plain text and ignore obvious universal linguistic structure clues. Existing PrLMs have shown that monolingual linguistic structure knowledge may bring about better performance. Thus we propose a novel multilingual PrLM that supports both explicit universal dependency parsing and implicit language modeling. Syntax in terms of universal dependency parse serves as not only pre-training objective but also learned representation in our model, which brings unprecedented PrLM interpretability and convenience in downstream task use. Our model outperforms two popular multilingual PrLM, multilingual-BERT and XLM-R, on cross-lingual natural language understanding (NLU) benchmarks and linguistic structure parsing datasets, demonstrating the effectiveness and stronger cross-lingual modeling capabilities of our approach.