However, the automation of MIS and RAMIS through the use of AI has been slow due to difficulties in data acquisition and curation, partially caused by the ethical considerations of training, testing and deploying AI models in medical environments.

This paper presents innovative designs for 3D-printed tumbling microrobots, specifically engineered for targeted in vivo drug delivery applications. The microrobot designs, created using stereolithography 3D printing technologies, incorporate permanent micro-magnets to enable actuation via a rotating magnetic field actuator system. The experimental framework encompasses a series of locomotion characterization tests to evaluate microrobot performance under various conditions. Testing variables include variations in microrobot geometries, actuation frequencies, and environmental conditions, such as dry and wet environments, and temperature changes. The paper outlines designs for three drug loading methods, along with comprehensive assessments thermal drug release using a focused ultrasound system, as well as biocompatibility tests. Animal model testing involves tissue phantoms and in vivo rat models, ensuring a thorough evaluation of the microrobots' performance and compatibility. The results highlight the robustness and adaptability of the proposed microrobot designs, showcasing the potential for efficient and targeted in vivo drug delivery. This novel approach addresses current limitations in existing tumbling microrobot designs and paves the way for advancements in targeted drug delivery within the large intestine.

High-resolution colon segmentation is crucial for clinical and research applications, such as digital twins and personalized medicine. However, the leading open-source abdominal segmentation tool, TotalSegmentator, struggles with accuracy for the colon, which has a complex and variable shape, requiring time-intensive labeling. Here, we present the first fully automatic high-resolution colon segmentation method. To develop it, we first created a high resolution colon dataset using a pipeline that combines region growing with interactive machine learning to efficiently and accurately label the colon on CT colonography (CTC) images. Based on the generated dataset consisting of 435 labeled CTC images we trained an nnU-Net model for fully automatic colon segmentation. Our fully automatic model achieved an average symmetric surface distance of 0.2 mm (vs. 4.0 mm from TotalSegmentator) and a 95th percentile Hausdorff distance of 1.0 mm (vs. 18 mm from TotalSegmentator). Our segmentation accuracy substantially surpasses TotalSegmentator. We share our trained model and pipeline code, providing the first and only open-source tool for high-resolution colon segmentation. Additionally, we created a large-scale dataset of publicly available high-resolution colon labels.

This paper introduces a size-adaptable robotic endoscope design, which aims to improve the efficiency and comfort of colonoscopy. The robotic endoscope proposed in this paper combines the expansion mechanism and the external drive system, which can adjust the shape according to the different pipe diameters, thus improving the stability and propulsion force during propulsion. As an actuator in the expansion mechanism, flexible bellows can provide a normal force of 3.89 N and an axial deformation of nearly 10mm at the maximum pressure, with a 53% expansion rate in the size of expandable tip. In the test of the locomotion performance of the prototype, we obtained the relationship with the propelling of the prototype by changing the friction coefficient of the pipe and the motor angular velocity. In the experiment with artificial bowel tissues, the prototype can generate a propelling force of 2.83 N, and the maximum linear speed is 29.29 m/s in average, and could produce effective propulsion when it passes through different pipe sizes. The results show that the prototype can realize the ability of shape adaptation in order to obtain more propulsion. The relationship between propelling force and traction force, structural optimization and miniaturization still need further exploration.

While previous studies have demonstrated the potential of AI to diagnose diseases in imaging data, clinical implementation is still lagging behind. This is partly because AI models require training with large numbers of examples only available for common diseases. In clinical reality, however, only few diseases are common, whereas the majority of diseases are less frequent (long-tail distribution). Current AI models overlook or misclassify these diseases. We propose a deep anomaly detection approach that only requires training data from common diseases to detect also all less frequent diseases. We collected two large real-world datasets of gastrointestinal biopsies, which are prototypical of the problem. Herein, the ten most common findings account for approximately 90% of cases, whereas the remaining 10% contained 56 disease entities, including many cancers. 17 million histological images from 5,423 cases were used for training and evaluation. Without any specific training for the diseases, our best-performing model reliably detected a broad spectrum of infrequent ("anomalous") pathologies with 95.0% (stomach) and 91.0% (colon) AUROC and generalized across scanners and hospitals. By design, the proposed anomaly detection can be expected to detect any pathological alteration in the diagnostic tail of gastrointestinal biopsies, including rare primary or metastatic cancers. This study establishes the first effective clinical application of AI-based anomaly detection in histopathology that can flag anomalous cases, facilitate case prioritization, reduce missed diagnoses and enhance the general safety of AI models, thereby driving AI adoption and automation in routine diagnostics and beyond.

Unlike routine tasks where consistency is prized, in creativity and innovation the goal is to create a diverse set of ideas. This paper delves into the burgeoning interest in employing Artificial Intelligence (AI) to enhance the productivity and quality of the idea generation process. While previous studies have found that the average quality of AI ideas is quite high, prior research also has pointed to the inability of AI-based brainstorming to create sufficient dispersion of ideas, which limits novelty and the quality of the overall best idea. Our research investigates methods to increase the dispersion in AI-generated ideas. Using GPT-4, we explore the effect of different prompting methods on Cosine Similarity, the number of unique ideas, and the speed with which the idea space gets exhausted. We do this in the domain of developing a new product development for college students, priced under $50. In this context, we find that (1) pools of ideas generated by GPT-4 with various plausible prompts are less diverse than ideas generated by groups of human subjects (2) the diversity of AI generated ideas can be substantially improved using prompt engineering (3) Chain-of-Thought (CoT) prompting leads to the highest diversity of ideas of all prompts we evaluated and was able to come close to what is achieved by groups of human subjects. It also was capable of generating the highest number of unique ideas of any prompt we studied.

Desktop-based virtual colonoscopy has been proven to be an asset in the identification of colon anomalies. The process is accurate, although time-consuming. The use of immersive interfaces for virtual colonoscopy is incipient and not yet understood. In this work, we present a new design exploring elements of the VR paradigm to make the immersive analysis more efficient while still effective. We also plan the conduction of experiments with experts to assess the multi-factor influences of coverage, duration, and diagnostic accuracy.