This paper presents a proof-of-concept demonstration of agent-to-agent communication across distributed systems, using only natural-language messages and without shared identifiers, structured schemas, or centralised data exchange. The prototype explores how multiple organisations (represented here as a Clinic, Insurer, and Specialist Network) can cooperate securely via pseudonymised case tokens, local data lookups, and controlled operational boundaries. The system uses Orpius as the underlying platform for multi-agent orchestration, tool execution, and privacy-preserving communication. All agents communicate through OperationRelay calls, exchanging concise natural-language summaries. Each agent operates on its own data (such as synthetic clinic records, insurance enrolment tables, and clinical guidance extracts), and none receives or reconstructs patient identity. The Clinic computes an HMAC-based pseudonymous token, the Insurer evaluates coverage rules and consults the Specialist agent, and the Specialist returns an appropriateness recommendation. The goal of this prototype is intentionally limited: to demonstrate feasibility, not to provide a clinically validated, production-ready system. No clinician review was conducted, and no evaluation beyond basic functional runs was performed. The work highlights architectural patterns, privacy considerations, and communication flows that enable distributed reasoning among specialised agents while keeping data local to each organisation. We conclude by outlining opportunities for more rigorous evaluation and future research in decentralised multi-agent systems.

Doctors are more like machines': my mother's worrying reliance on AI for health advice Tired of a two-day commute to see her overworked doctor, my mother turned to tech for help with her kidney disease. E very few months, my mother, a 57-year-old kidney transplant patient who lives in a small city in eastern China, embarks on a two-day journey to see her doctor. She fills her backpack with a change of clothes, a stack of medical reports and a few boiled eggs to snack on. Then, she takes a 90-minute ride on a high-speed train and checks into a hotel in the eastern metropolis of Hangzhou. At 7am the next day, she lines up with hundreds of others to get her blood taken in a long hospital hall that buzzes like a crowded marketplace. In the afternoon, when the lab results arrive, she makes her way to a specialist's clinic. She gets about three minutes with the doctor. Then, my mother packs up and starts the long commute home. My mother began using China's leading AI chatbot to diagnose her symptoms this past winter. She would lie down on her couch and open the app on her iPhone. "Hi," she said in her first message to the chatbot, on 2 February. How can I assist you today?" the system responded instantly, adding a smiley emoji.

Harmonizing medication data across Electronic Health Record (EHR) systems is a persistent barrier to monitoring medications for opioid use disorder (MOUD). In heterogeneous EHR systems, key prescription attributes are scattered across differently formatted fields and freetext notes. We present a practical framework that customizes open source large language models (LLMs), including Llama, Qwen, Gemma, and MedGemma, to extract a unified set of MOUD prescription attributes (prescription date, drug name, duration, total quantity, daily quantity, and refills) from heterogeneous, site specific data and compute a standardized metric of medication coverage, \emph{MOUD days}, per patient. Our pipeline processes records directly in a fixed JSON schema, followed by lightweight normalization and cross-field consistency checks. We evaluate the system on prescription level EHR data from five clinics in a national OUD study (25{,}605 records from 1{,}257 patients), using a previously annotated benchmark of 10{,}369 records (776 patients) as the ground truth. Performance is reported as coverage (share of records with a valid, matchable output) and record-level exact-match accuracy. Larger models perform best overall: Qwen2.5-32B achieves \textbf{93.4\%} coverage with \textbf{93.0\%} exact-match accuracy across clinics, and MedGemma-27B attains \textbf{93.1\%}/\textbf{92.2\%}. A brief error review highlights three common issues and fixes: imputing missing dosage fields using within-drug norms, handling monthly/weekly injectables (e.g., Vivitrol) by setting duration from the documented schedule, and adding unit checks to prevent mass units (e.g., ``250 g'') from being misread as daily counts. By removing brittle, site-specific ETL and supporting local, privacy-preserving deployment, this approach enables consistent cross-site analyses of MOUD exposure, adherence, and retention in real-world settings.

Federated Learning (FL) offers a promising approach for training clinical AI models without centralizing sensitive patient data. However, its real-world adoption is hindered by challenges related to privacy, resource constraints, and compliance. Existing Differential Privacy (DP) approaches often apply uniform noise, which disproportionately degrades model performance, even among well-compliant institutions. In this work, we propose a novel compliance-aware FL framework that enhances DP by adaptively adjusting noise based on quantifiable client compliance scores. Additionally, we introduce a compliance scoring tool based on key healthcare and security standards to promote secure, inclusive, and equitable participation across diverse clinical settings. Extensive experiments on public datasets demonstrate that integrating under-resourced, less compliant clinics with highly regulated institutions yields accuracy improvements of up to 15% over traditional FL. This work advances FL by balancing privacy, compliance, and performance, making it a viable solution for real-world clinical workflows in global healthcare.

"Our focus is really on what we can do to pull the doctor out of the visit," says Akido's CTO. Imagine this: You've been feeling unwell, so you call up your doctor's office to make an appointment. At the appointment, you aren't rushed through describing your health concerns; instead, you have a full half hour to share your symptoms and worries and the exhaustive details of your health history with someone who listens attentively and asks thoughtful follow-up questions. You leave with a diagnosis, a treatment plan, and the sense that, for once, you've been able to discuss your health with the care that it merits. AI companies have stopped warning you that their chatbots aren't doctors Once cautious, OpenAI, Grok, and others will now dive into giving unverified medical advice with virtually no disclaimers. You might not have spoken to a doctor, or other licensed medical practitioner, at all.

Sign up for the Slatest to get the most insightful analysis, criticism, and advice out there, delivered to your inbox daily. I am a proud late adopter of new technology. I had a StarTAC well into the 21st century, fearing the limitless access to digital information and services that smartphones would bring and the way they would rob us of our time and attention and humanity. Though this realization offers little solace as I stare into my phone hundreds of hours a day.) I traveled with my books of CDs and my Discman well into the era when Transportation Security Administration agents would look at them with curiosity and suspicion.

We list all notations used in this paper in Table 1.

We evaluate the impact of large language model-based clinical decision support in live care. In partnership with Penda Health, a network of primary care clinics in Nairobi, Kenya, we studied AI Consult, a tool that serves as a safety net for clinicians by identifying potential documentation and clinical decision-making errors. AI Consult integrates into clinician workflows, activating only when needed and preserving clinician autonomy. We conducted a quality improvement study, comparing outcomes for 39,849 patient visits performed by clinicians with or without access to AI Consult across 15 clinics. Visits were rated by independent physicians to identify clinical errors. Clinicians with access to AI Consult made relatively fewer errors: 16% fewer diagnostic errors and 13% fewer treatment errors. In absolute terms, the introduction of AI Consult would avert diagnostic errors in 22,000 visits and treatment errors in 29,000 visits annually at Penda alone. In a survey of clinicians with AI Consult, all clinicians said that AI Consult improved the quality of care they delivered, with 75% saying the effect was "substantial". These results required a clinical workflow-aligned AI Consult implementation and active deployment to encourage clinician uptake. We hope this study demonstrates the potential for LLM-based clinical decision support tools to reduce errors in real-world settings and provides a practical framework for advancing responsible adoption.

Breakthroughs, discoveries, and DIY tips sent every weekday. The ticking tyranny of 2 a.m. after you climbed into bed–responsibly–at 11. As the minutes go by, all you can think about is the importance of good sleep for function, mood, and productivity. What's worse, the big white letters on your sleep score will read "poor" like a middle school quiz. And while health-tracking devices have helped many gain insight into their bodies, hyperfixation on sleep metrics can backfire.

Lanea George pulls open a steel security door and enters a windowless room where a video camera stares at what looks like a commercial-grade refrigerator. The machine, dubbed Bodhi, whirrs and spins before spitting out seven small plastic bottles containing precisely 70ml of methadone, a bright pink liquid resembling cherry cough syrup. It is used as a substitute for morphine or heroin in addiction treatment. She scoops the bottles off the tray, bundles them with a rubber band and sets them on a shelf. It's not yet 10am and George, the nurse manager at Man Alive, an opioid treatment program – known colloquially as a methadone clinic – in Baltimore, has already finished prepping the doses for the 100 or so patients who will arrive the next day.