In the context of personalized federated learning, existing approaches train a global model to extract transferable representations, based on which any client could train personalized models with a limited number of data samples. Self-supervised learning is considered a promising direction as the global model it produces is generic and facilitates personalization for all clients fairly. However, when data is heterogeneous across clients, the global model trained using SSL is unable to learn high-quality personalized models. In this paper, we show that when the global model is trained with SSL without modifications, its produced representations have fuzzy class boundaries. As a result, personalized learning within each client produces models with low accuracy. In order to improve SSL towards better accuracy without sacrificing its advantage in fairness, we propose Calibre, a new personalized federated learning framework designed to calibrate SSL representations by maintaining a suitable balance between more generic and more client-specific representations. Calibre is designed based on theoretically-sound properties, and introduces (1) a client-specific prototype loss as an auxiliary training objective; and (2) an aggregation algorithm guided by such prototypes across clients. Our experimental results in an extensive array of non-i.i.d.~settings show that Calibre achieves state-of-the-art performance in terms of both mean accuracy and fairness across clients. Code repo: https://github.com/TL-System/plato/tree/main/examples/ssl/calibre.

Purpose: To describe SLOctolyzer: an open-source analysis toolkit for en face retinal vessels appearing in infrared reflectance scanning laser ophthalmoscopy (SLO) images. Methods: SLOctolyzer includes two main modules: segmentation and measurement. The segmentation module use deep learning methods to delineate retinal anatomy, while the measurement module quantifies key retinal vascular features such as vessel complexity, density, tortuosity, and calibre. We evaluate the segmentation module using unseen data and measure its reproducibility. Results: SLOctolyzer's segmentation module performed well against unseen internal test data (Dice for all-vessels, 0.9097; arteries, 0.8376; veins, 0.8525; optic disc, 0.9430; fovea, 0.8837). External validation against severe retinal pathology showed decreased performance (Dice for arteries, 0.7180; veins, 0.7470; optic disc, 0.9032). SLOctolyzer had good reproducibility (mean difference for fractal dimension, -0.0007; vessel density, -0.0003; vessel calibre, -0.3154 $\mu$m; tortuosity density, 0.0013). SLOctolyzer can process a macula-centred SLO image in under 20 seconds and a disc-centred SLO image in under 30 seconds using a standard laptop CPU. Conclusions: To our knowledge, SLOctolyzer is the first open-source tool to convert raw SLO images into reproducible and clinically meaningful retinal vascular parameters. SLO images are captured simultaneous to optical coherence tomography (OCT), and we believe our software will be useful for extracting retinal vascular measurements from large OCT image sets and linking them to ocular or systemic diseases. It requires no specialist knowledge or proprietary software, and allows manual correction of segmentations and re-computing of vascular metrics. SLOctolyzer is freely available at https://github.com/jaburke166/SLOctolyzer.