We first clarify the behavior of local CGMs (see Def. 1) under interventions. "if": If it holds that "only if": If there is an edge In this section, we give the approximation we use for the KL divergence in Eq. 4. We first state the Note that this term can become negative, whereas the KL is non-negative. With this, the above formulas can be further simplified. The goal of the agent is to move the object to a goal zone. For our experiment in Sec. 5 evaluating the causal influence detection, we need to determine whether Then, the following procedure is repeated for each starting location and action: after resetting the simulator, the end effector is manually moved to one of the starting locations, one of the maximal actions in each dimension (i.e., Last, we also label a state as "agent in control" when there is an actual contact between This dataset only has 3.3% transitions with influence (i.e.

Reinforcement learning (RL) is a promising route towards versatile and dexterous artificial agents.

Classical probabilistic graphical models face fundamental challenges in modern data environments, which are characterized by high dimensionality, source heterogeneity, and stringent data-sharing constraints. In this work, we revisit the Ising model, a well-established member of the Markov Random Field (MRF) family, and develop a distributed framework that enables scalable and privacy-preserving representation learning from large-scale binary data with inherent low-rank structure. Our approach optimizes a non-convex surrogate loss function via bi-factored gradient descent, offering substantial computational and communication advantages over conventional convex approaches. We evaluate our algorithm on multi-institutional electronic health record (EHR) datasets from 58,248 patients across the University of Pittsburgh Medical Center (UPMC) and Mass General Brigham (MGB), demonstrating superior performance in global representation learning and downstream clinical tasks, including relationship detection, patient phenotyping, and patient clustering. These results highlight a broader potential for statistical inference in federated, high-dimensional settings while addressing the practical challenges of data complexity and multi-institutional integration.

As Large Language Models (LLMs) are increasingly deployed as social agents and trained to produce humor and irony, a question emerges: when encountering witty AI remarks, do people interpret these as intentional communication or mere computational output? This study investigates whether people adopt the intentional stance, attributing mental states to explain behavior,toward AI during irony comprehension. Irony provides an ideal paradigm because it requires distinguishing intentional contradictions from unintended errors through effortful semantic reanalysis. We compared behavioral and neural responses to ironic statements from AI versus human sources using established ERP components: P200 reflecting early incongruity detection and P600 indexing cognitive efforts in reinterpreting incongruity as deliberate irony. Results demonstrate that people do not fully adopt the intentional stance toward AI-generated irony. Behaviorally, participants attributed incongruity to deliberate communication for both sources, though significantly less for AI than human, showing greater tendency to interpret AI incongruities as computational errors. Neural data revealed attenuated P200 and P600 effects for AI-generated irony, suggesting reduced effortful detection and reanalysis consistent with diminished attribution of communicative intent. Notably, people who perceived AI as more sincere showed larger P200 and P600 effects for AI-generated irony, suggesting that intentional stance adoption is calibrated by specific mental models of artificial agents. These findings reveal that source attribution shapes neural processing of social-communicative phenomena. Despite current LLMs' linguistic sophistication, achieving genuine social agency requires more than linguistic competence, it necessitates a shift in how humans perceive and attribute intentionality to artificial agents.

As AI companions become capable of human-like communication, including telling jokes, understanding how people cognitively and emotionally respond to AI humor becomes increasingly important. This study used electroencephalography (EEG) to compare how people process humor from AI versus human sources. Behavioral analysis revealed that participants rated AI and human humor as comparably funny. However, neurophysiological data showed that AI humor elicited a smaller N400 effect, suggesting reduced cognitive effort during the processing of incongruity. This was accompanied by a larger Late Positive Potential (LPP), indicating a greater degree of surprise and emotional response. This enhanced LPP likely stems from the violation of low initial expectations regarding AI's comedic capabilities. Furthermore, a key temporal dynamic emerged: human humor showed habituation effects, marked by an increasing N400 and a decreasing LPP over time. In contrast, AI humor demonstrated increasing processing efficiency and emotional reward, with a decreasing N400 and an increasing LPP. This trajectory reveals how the brain can dynamically update its predictive model of AI capabilities. This process of cumulative reinforcement challenges "algorithm aversion" in humor, as it demonstrates how cognitive adaptation to AI's language patterns can lead to an intensified emotional reward. Additionally, participants' social attitudes toward AI modulated these neural responses, with higher perceived AI trustworthiness correlating with enhanced emotional engagement. These findings indicate that the brain responds to AI humor with surprisingly positive and intense reactions, highlighting humor's potential for fostering genuine engagement in human-AI social interaction.

Integrative analysis of multi-institutional Electronic Health Record (EHR) data enhances the reliability and generalizability of translational research by leveraging larger, more diverse patient cohorts and incorporating multiple data modalities. However, harmonizing EHR data across institutions poses major challenges due to data heterogeneity, semantic differences, and privacy concerns. To address these challenges, we introduce $\textit{PEHRT}$, a standardized pipeline for efficient EHR data harmonization consisting of two core modules: (1) data pre-processing and (2) representation learning. PEHRT maps EHR data to standard coding systems and uses advanced machine learning to generate research-ready datasets without requiring individual-level data sharing. Our pipeline is also data model agnostic and designed for streamlined execution across institutions based on our extensive real-world experience. We provide a complete suite of open source software, accompanied by a user-friendly tutorial, and demonstrate the utility of PEHRT in a variety of tasks using data from diverse healthcare systems.

There is justifiable interest in leveraging conversational AI (CAI) for health across the majority world, but to be effective, CAI must respond appropriately within cultur ally and linguistically diverse context s . Therefore, we need ways to address the fact that current LLMs exclude many lived experience s globally . Various advances are underway which focus on top - down approaches and increas ing training data . In this paper, we aim to complement these with a bottom - up locally - grounded approach based on qualitative data collected during participatory workshops in Latin America. Our goal is to construct a rich and human - centred understanding o f: a) potential areas of cultural misalignment in digital health; b) regional perspectives on chatbots for health and c) strategies for creating culturally - appropriate CAI; with a focus on the understudied Latin American context . Our findings show that academic boundaries on notions of cultur e lose meaning at the ground level and technologies will need to engage with a broad er framework; one that encapsulates the way economics, politics, geogr aphy and local logistics are entangled in cultural experience. To this end, we introduce a framework for ' Pluriversal Conversational AI for H ealth ' which allows for the possibility that more relationality and tolerance, rather than just more data, may be called for .

Collective Adaptive Intelligence (CAI) represent a transformative approach in embodied AI, wherein numerous autonomous agents collaborate, adapt, and self-organize to navigate complex, dynamic environments. By enabling systems to reconfigure themselves in response to unforeseen challenges, CAI facilitate robust performance in real-world scenarios. This article introduces a conceptual framework for designing and analyzing CAI. It delineates key attributes including task generalization, resilience, scalability, and self-assembly, aiming to bridge theoretical foundations with practical methodologies for engineering adaptive, emergent intelligence. By providing a structured foundation for understanding and implementing CAI, this work seeks to guide researchers and practitioners in developing more resilient, scalable, and adaptable AI systems across various domains.