Physics-Informed Machine Learning (PIML) has successfully integrated mechanistic understanding into machine learning, particularly in domains governed by well-known physical laws. This success has motivated efforts to apply PIML to biology, a field rich in dynamical systems but shaped by different constraints. Biological modeling, however, presents unique challenges: multi-faceted and uncertain prior knowledge, heterogeneous and noisy data, partial observability, and complex, high-dimensional networks. In this position paper, we argue that these challenges should not be seen as obstacles to PIML, but as catalysts for its evolution. We propose Biology-Informed Machine Learning (BIML): a principled extension of PIML that retains its structural grounding while adapting to the practical realities of biology. Rather than replacing PIML, BIML retools its methods to operate under softer, probabilistic forms of prior knowledge. We outline four foundational pillars as a roadmap for this transition: uncertainty quantification, contextualization, constrained latent structure inference, and scalability. Foundation Models and Large Language Models will be key enablers, bridging human expertise with computational modeling. We conclude with concrete recommendations to build the BIML ecosystem and channel PIML-inspired innovation toward challenges of high scientific and societal relevance.

Physics-Informed Machine Learning (PIML) has successfully integrated mechanistic understanding into machine learning, particularly in domains governed by well-known physical laws.This success has motivated efforts to apply PIML to biology, a field rich in dynamical systems but shaped by different constraints.Biological modeling, however, presents unique challenges: multi-faceted and uncertain prior knowledge, heterogeneous and noisy data, partial observability, and complex, high-dimensional networks.\textbf{In

Each year the AAAI recognizes a group of individuals who have made significant, sustained contributions to the field of artificial intelligence by appointing them as Fellows. Over the course of the next few months, we'll be talking to some of the 2026 AAAI Fellows. In this interview, we met with Tanya Berger-Wolf, who was elected as a Fellow . We found out about her latest research developing a foundation model for biology, the insights this model can provide, interesting collaborations over the years, and what the future has in store. Could you start with a quick introduction and tell us about the broad area that you're working in? My area of research is in AI for ecology, biodiversity, and conservation.

Why it's high time we stopped anthropomorphising ants We have long drawn parallels between ants and humans. Now we are comparing the insects to computers. Pollution is making many cities unlivable for their human inhabitants, but it is also tearing ant families and communities apart. Ants recognise each other by sniffing a thin layer of hydrocarbons on the outside of their exoskeletons; each colony has a specific "smell". But a new study reveals that ozone emissions can change the structure of these hydrocarbons.

RNA plays a pivotal role in translating genetic instructions into functional outcomes, underscoring its importance in biological processes and disease mechanisms.

Addressing these challenges requires scale. To that end we introduce ProteinGym, a large-scale and holistic set of benchmarks specifically designed for protein fitness prediction and design.

However,whenlargeamounts ofannotated dataareavailable, models thatallow end-to-end training such as neural networks are often preferred.

We define an easy and hard split.