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AdaptiveLearningofRank-OneModelsfor EfficientPairwiseSequenceAlignment
A key step in many bioinformatics analysis pipelines is the identification of regions of similarity between pairs of DNA sequencing reads. This task, known aspairwise sequence alignment, is a heavy computational burden, particularly in the context of third-generation long-read sequencing technologies,whichproducenoisyreads[45].
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SafeCiM: Investigating Resilience of Hybrid Floating-Point Compute-in-Memory Deep Learning Accelerators
Bhattacharya, Swastik, Das, Sanjay, Menon, Anand, Kundu, Shamik, Raha, Arnab, Basu, Kanad
Deep Neural Networks (DNNs) continue to grow in complexity with Large Language Models (LLMs) incorporating vast numbers of parameters. Handling these parameters efficiently in traditional accelerators is limited by data-transmission bottlenecks, motivating Compute-in-Memory (CiM) architectures that integrate computation within or near memory to reduce data movement. Recent work has explored CiM designs using Floating-Point (FP) and Integer (INT) operations. FP computations typically deliver higher output quality due to their wider dynamic range and precision, benefiting precision-sensitive Generative AI applications. These include models such as LLMs, thus driving advancements in FP-CiM accelerators. However, the vulnerability of FP-CiM to hardware faults remains underexplored, posing a major reliability concern in mission-critical settings. To address this gap, we systematically analyze hardware fault effects in FP-CiM by introducing bit-flip faults at key computational stages, including digital multipliers, CiM memory cells, and digital adder trees. Experiments with Convolutional Neural Networks (CNNs) such as AlexNet and state-of-the-art LLMs including LLaMA-3.2-1B and Qwen-0.3B-Base reveal how faults at each stage affect inference accuracy. Notably, a single adder fault can reduce LLM accuracy to 0%. Based on these insights, we propose a fault-resilient design, SafeCiM, that mitigates fault impact far better than a naive FP-CiM with a pre-alignment stage. For example, with 4096 MAC units, SafeCiM reduces accuracy degradation by up to 49x for a single adder fault compared to the baseline FP-CiM architecture.
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