AI Scientific Assistant Core (AISAC) is an integrated multi-agent system developed at Argonne National Laboratory for scientific and engineering workflows. AISAC builds on established technologies - LangGraph for orchestration, FAISS for vector search, and SQLite for persistence - and integrates them into a unified system prototype focused on transparency, provenance tracking, and scientific adaptability. The system implements a Router-Planner-Coordinator workflow and an optional Evaluator role, using prompt-engineered agents coordinated via LangGraph's StateGraph and supported by helper agents such as a Researcher. Each role is defined through custom system prompts that enforce structured JSON outputs. A hybrid memory approach (FAISS + SQLite) enables both semantic retrieval and structured conversation history. An incremental indexing strategy based on file hashing minimizes redundant re-embedding when scientific corpora evolve. A configuration-driven project bootstrap layer allows research teams to customize tools, prompts, and data sources without modifying core code. All agent decisions, tool invocations, and retrievals are logged and visualized through a custom Gradio interface, providing step-by-step transparency for each reasoning episode. The authors have applied AISAC to multiple research areas at Argonne, including specialized deployments for waste-to-products research and energy process safety, as well as general-purpose scientific assistance, demonstrating its cross-domain applicability.

IMAGE: AISACS received a total of five inputs and churned out dosage direction probabilities for erythropoiesis-stimulating agents and iron supplements. It was noted that AISACS sometimes produces "clinically appropriate " directions that... view more Anemia, a condition characterized by the lack of healthy red blood cells in the body, is common in patients with chronic kidney disease who need to undergo routine hemodialysis (a process that helps to "clean" the blood when the kidneys don't function well). Thus, red blood cell-stimulating agents (called "erythropoiesis-stimulating agents" or ESAs) and iron supplements (ISs) are administered as part of this process. But, complications can arise if the patients have an altered iron metabolism or poor response to medications. Moreover, the medications tend to be expensive and impose a heavy financial burden on public health.