Greedy importance sampling is an unbiased estimation technique that reduces thevariance of standard importance sampling by explicitly searching for modes in the estimation objective. Previous work has demonstrated thefeasibility of implementing this method and proved that the technique is unbiased in both discrete and continuous domains. In this paper we present a reformulation of greedy importance sampling that eliminates the free parameters from the original estimator, and introduces a new regularization strategy that further reduces variance without compromising unbiasedness.The resulting estimator is shown to be effective for difficult estimation problems arising in Markov random field inference. Inparticular, improvements are achieved over standard MCMC estimators when the distribution has multiple peaked modes.

Model selection is linked to model assessment, which is the problem of comparing different models, or model parameters, for a specific learning task. For supervised learning, the standard practical technique is crossvalidation, whichis not applicable for semi-supervised and unsupervised settings. In this paper, a new model assessment scheme is introduced which is based on a notion of stability. The stability measure yields an upper bound to cross-validation in the supervised case, but extends to semi-supervised and unsupervised problems. In the experimental part, the performance of the stability measure is studied for model order selection incomparison to standard techniques in this area.

We describe a self-configuring neuromorphic chip that uses a model of activity-dependent axon remodeling to automatically wire topographic maps based solely on input correlations. Axons are guided by growth cones, which are modeled in analog VLSI for the first time. Growth cones migrate up neurotropin gradients, which are represented by charge diffusing in transistor channels. Virtual axons move by rerouting address-events. We refined an initially gross topographic projection by simulating retinal wave input. 1 Neuromorphic Systems Neuromorphic engineers are attempting to match the computational efficiency of biological systems by morphing neurocircuitry into silicon circuits [1].

A new approach to inference in belief networks has been recently proposed, which is based on an algebraic representation of belief networks using multi-linear functions. According to this approach, the key computational question is that of representing multi-linear functions compactly, since inference reduces to a simple process of ev aluating and differentiating such functions. W e show here that mainstream inference algorithms based on jointrees are a special case of this approach in a v ery precise sense. W e use this result to prov e new properties of jointree algorithms, and then discuss some of its practical and theoretical implications.

The extraction of a single high-quality image from a set of lowresolution imagesis an important problem which arises in fields such as remote sensing, surveillance, medical imaging and the extraction ofstill images from video. Typical approaches are based on the use of cross-correlation to register the images followed by the inversion of the transformation from the unknown high resolution imageto the observed low resolution images, using regularization toresolve the ill-posed nature of the inversion process. In this paper we develop a Bayesian treatment of the super-resolution problem in which the likelihood function for the image registration parametersis based on a marginalization over the unknown high-resolution image. This approach allows us to estimate the unknown point spread function, and is rendered tractable through the introduction of a Gaussian process prior over images. Results indicate a significant improvement over techniques based on MAP (maximum a-posteriori) point optimization of the high resolution image and associated registration parameters. 1 Introduction

The responses of cortical sensory neurons are notoriously variable, with the number of spikes evoked by identical stimuli varying significantly from trial to trial. This variability is most often interpreted as'noise', purely detrimental to the sensory system. In this paper, we propose an alternative viewin which the variability is related to the uncertainty, about world parameters, which is inherent in the sensory stimulus. Specifically, theresponses of a population of neurons are interpreted as stochastic samples from the posterior distribution in a latent variable model. In addition to giving theoretical arguments supporting such a representational scheme,we provide simulations suggesting how some aspects of response variability might be understood in this framework.

The goal of this work is to accurately detect and localize boundaries in natural scenes using local image measurements. We formulate features that respond to characteristic changes in brightness and texture associated with natural boundaries. In order to combine the information from these features in an optimal way, a classifier is trained using human labeled images as ground truth. We present precision-recall curves showing that the resulting detector outperforms existing approaches.

Given is a problem sequence and a probability distribution (the bias) on programs computing solution candidates. We present an optimally fast way of incrementally solving each task in the sequence. Bias shifts are computed by program prefixes that modify the distribution on their suffixes byreusing successful code for previous tasks (stored in non-modifiable memory). No tested program gets more runtime than its probability times the total search time.

An optoelectronic implementation of a spiking neuron model based on the FitzHugh-Nagumo equations is presented. A tunable semiconductor lasersource and a spectral filter provide a nonlinear mapping from driver voltage to detected signal. Linear electronic feedback completes the implementation, which allows either electronic or optical input signals. Experimentalresults for a single system and numeric results of model interaction confirm that important features of spiking neural models canbe implemented through this approach.

If the cortex uses spike timing to compute, the timing of the spikes must be robust to perturbations. Based on a recent framework that provides a simple criterion to determine whether a spike sequence produced by a generic network is sensitive to initial conditions, and numerical simulations of a variety of network architectures, we argue within the limits set by our model of the neuron, that it is unlikely that precise sequences of spike timings are used for computation under conditions typically found in the cortex. 1 Introduction