This study reviewed the use of Large Language Models (LLMs) in healthcare, focusing on their training corpora, customization techniques, and evaluation metrics. A systematic search of studies from 2021 to 2024 identified 61 articles. Four types of corpora were used: clinical resources, literature, open-source datasets, and web-crawled data. Common construction techniques included pre-training, prompt engineering, and retrieval-augmented generation, with 44 studies combining multiple methods. Evaluation metrics were categorized into process, usability, and outcome metrics, with outcome metrics divided into model-based and expert-assessed outcomes. The study identified critical gaps in corpus fairness, which contributed to biases from geographic, cultural, and socio-economic factors. The reliance on unverified or unstructured data highlighted the need for better integration of evidence-based clinical guidelines. Future research should focus on developing a tiered corpus architecture with vetted sources and dynamic weighting, while ensuring model transparency. Additionally, the lack of standardized evaluation frameworks for domain-specific models called for comprehensive validation of LLMs in real-world healthcare settings.

The available evidence suggests that dynamic functional connectivity (dFC) can capture time-varying abnormalities in brain activity in resting-state cerebral functional magnetic resonance imaging (rs-fMRI) data and has a natural advantage in uncovering mechanisms of abnormal brain activity in schizophrenia(SZ) patients. Hence, an advanced dynamic brain network analysis model called the temporal brain category graph convolutional network (Temporal-BCGCN) was employed. Firstly, a unique dynamic brain network analysis module, DSF-BrainNet, was designed to construct dynamic synchronization features. Subsequently, a revolutionary graph convolution method, TemporalConv, was proposed, based on the synchronous temporal properties of feature. Finally, the first modular abnormal hemispherical lateralization test tool in deep learning based on rs-fMRI data, named CategoryPool, was proposed. This study was validated on COBRE and UCLA datasets and achieved 83.62% and 89.71% average accuracies, respectively, outperforming the baseline model and other state-of-the-art methods. The ablation results also demonstrate the advantages of TemporalConv over the traditional edge feature graph convolution approach and the improvement of CategoryPool over the classical graph pooling approach. Interestingly, this study showed that the lower order perceptual system and higher order network regions in the left hemisphere are more severely dysfunctional than in the right hemisphere in SZ and reaffirms the importance of the left medial superior frontal gyrus in SZ. Our core code is available at: https://github.com/swfen/Temporal-BCGCN.

Predicting the behaviors of Hamiltonian systems has been drawing increasing attention in scientific machine learning. However, the vast majority of the literature was focused on predicting separable Hamiltonian systems with their kinematic and potential energy terms being explicitly decoupled, while building data-driven paradigms to predict nonseparable Hamiltonian systems that are ubiquitous in fluid dynamics and quantum mechanics were rarely explored. The main computational challenge lies in the effective embedding of symplectic priors to describe the inherently coupled evolution of position and momentum, which typically exhibits intricate dynamics with many degrees of freedom. To solve the problem, we propose a novel neural network architecture, Nonseparable Symplectic Neural Networks (NSSNNs), to uncover and embed the symplectic structure of a nonseparable Hamiltonian system from limited observation data. The enabling mechanics of our approach is an augmented symplectic time integrator to decouple the position and momentum energy terms and facilitate their evolution. We demonstrated the efficacy and versatility of our method by predicting a wide range of Hamiltonian systems, both separable and nonseparable, including vortical flow and quantum system. We showed the unique computational merits of our approach to yield long-term, accurate, and robust predictions for large-scale Hamiltonian systems by rigorously enforcing symplectomorphism.