Fake news on social media platforms poses a significant threat to societal systems, underscoring the urgent need for advanced detection methods. The existing detection methods can be divided into machine intelligence-based, crowd intelligence-based, and hybrid intelligence-based methods. Among them, hybrid intelligence-based methods achieve the best performance but fail to consider the reliability issue in detection. In light of this, we propose a novel Reliability Aware Hybrid Intelligence (RAHI) method for fake news detection. Our method comprises three integral modules. The first module employs a Bayesian deep learning model to capture the inherent reliability within machine intelligence. The second module uses an Item Response Theory (IRT)-based user response aggregation to account for the reliability in crowd intelligence. The third module introduces a new distribution fusion mechanism, which takes the distributions derived from both machine and crowd intelligence as input, and outputs a fused distribution that provides predictions along with the associated reliability. The experiments on the Weibo dataset demonstrate the advantages of our method. This study contributes to the research field with a novel RAHI-based method, and the code is shared at https://github.com/Kangwei-g/RAHI. This study has practical implications for three key stakeholders: internet users, online platform managers, and the government.

While short-form videos head to reshape the entire social media landscape, experts are exceedingly worried about their depressive impacts on viewers, as evidenced by medical studies. To prevent widespread consequences, platforms are eager to predict these videos' impact on viewers' mental health. Subsequently, they can take intervention measures, such as revising recommendation algorithms and displaying viewer discretion. Nevertheless, applicable predictive methods lack relevance to well-established medical knowledge, which outlines clinically proven external and environmental factors of depression. To account for such medical knowledge, we resort to an emergent methodological discipline, seeded Neural Topic Models (NTMs). However, existing seeded NTMs suffer from the limitations of single-origin topics, unknown topic sources, unclear seed supervision, and suboptimal convergence. To address those challenges, we develop a novel Knowledge-guided Multimodal NTM to predict a short-form video's depressive impact on viewers. Extensive empirical analyses using TikTok and Douyin datasets prove that our method outperforms state-of-the-art benchmarks. Our method also discovers medically relevant topics from videos that are linked to depressive impact. We contribute to IS with a novel video analytics method that is generalizable to other video classification problems. Practically, our method can help platforms understand videos' mental impacts, thus adjusting recommendations and video topic disclosure.

This study harnesses state-of-the-art AI technology for chronic disease management, specifically in detecting various mental disorders through user-generated textual content. Existing studies typically rely on fully supervised machine learning, which presents challenges such as the labor-intensive manual process of annotating extensive training data for each disease and the need to design specialized deep learning architectures for each problem. To address such challenges, we propose a novel framework that leverages advanced AI techniques, including large language models and multi-prompt engineering. Specifically, we address two key technical challenges in data-driven chronic disease management: (1) developing personalized prompts to represent each user's uniqueness and (2) incorporating medical knowledge into prompts to provide context for chronic disease detection, instruct learning objectives, and operationalize prediction goals. We evaluate our method using four mental disorders, which are prevalent chronic diseases worldwide, as research cases. On the depression detection task, our method (F1 = 0.975~0.978) significantly outperforms traditional supervised learning paradigms, including feature engineering (F1 = 0.760) and architecture engineering (F1 = 0.756). Meanwhile, our approach demonstrates success in few-shot learning, i.e., requiring only a minimal number of training examples to detect chronic diseases based on user-generated textual content (i.e., only 2, 10, or 100 subjects). Moreover, our method can be generalized to other mental disorder detection tasks, including anorexia, pathological gambling, and self-harm (F1 = 0.919~0.978).

Depression is a common disease worldwide. It is difficult to diagnose and continues to be underdiagnosed. Because depressed patients constantly share their symptoms, major life events, and treatments on social media, researchers are turning to user-generated digital traces on social media for depression detection. Such methods have distinct advantages in combating depression because they can facilitate innovative approaches to fight depression and alleviate its social and economic burden. However, most existing studies lack effective means to incorporate established medical domain knowledge in depression detection or suffer from feature extraction difficulties that impede greater performance. Following the design science research paradigm, we propose a Deep Knowledge-aware Depression Detection (DKDD) framework to accurately detect social media users at risk of depression and explain the critical factors that contribute to such detection. Extensive empirical studies with real-world data demonstrate that, by incorporating domain knowledge, our method outperforms existing state-of-the-art methods. Our work has significant implications for IS research in knowledge-aware machine learning, digital traces utilization, and NLP research in IS. Practically, by providing early detection and explaining the critical factors, DKDD can supplement clinical depression screening and enable large-scale evaluations of a population's mental health status.

Depression is the most prevalent and serious mental illness, which induces grave financial and societal ramifications. Depression detection is key for early intervention to mitigate those consequences. Such a high-stake decision inherently necessitates interpretability. Although a few depression detection studies attempt to explain the decision based on the importance score or attention weights, these explanations misalign with the clinical depression diagnosis criterion that is based on depressive symptoms. To fill this gap, we follow the computational design science paradigm to develop a novel Multi-Scale Temporal Prototype Network (MSTPNet). MSTPNet innovatively detects and interprets depressive symptoms as well as how long they last. Extensive empirical analyses using a large-scale dataset show that MSTPNet outperforms state-of-the-art depression detection methods with an F1-score of 0.851. This result also reveals new symptoms that are unnoted in the survey approach, such as sharing admiration for a different life. We further conduct a user study to demonstrate its superiority over the benchmarks in interpretability. This study contributes to IS literature with a novel interpretable deep learning model for depression detection in social media. In practice, our proposed method can be implemented in social media platforms to provide personalized online resources for detected depressed patients.

Virtual health has been acclaimed as a transformative force in healthcare delivery. Yet, its dropout issue is critical that leads to poor health outcomes, increased health, societal, and economic costs. Timely prediction of patient dropout enables stakeholders to take proactive steps to address patients' concerns, potentially improving retention rates. In virtual health, the information asymmetries inherent in its delivery format, between different stakeholders, and across different healthcare delivery systems hinder the performance of existing predictive methods. To resolve those information asymmetries, we propose a Multimodal Dynamic Knowledge-driven Dropout Prediction (MDKDP) framework that learns implicit and explicit knowledge from doctor-patient dialogues and the dynamic and complex networks of various stakeholders in both online and offline healthcare delivery systems. We evaluate MDKDP by partnering with one of the largest virtual health platforms in China. MDKDP improves the F1-score by 3.26 percentage points relative to the best benchmark. Comprehensive robustness analyses show that integrating stakeholder attributes, knowledge dynamics, and compact bilinear pooling significantly improves the performance. Our work provides significant implications for healthcare IT by revealing the value of mining relations and knowledge across different service modalities. Practically, MDKDP offers a novel design artifact for virtual health platforms in patient dropout management.

Health misinformation on social media devastates physical and mental health, invalidates health gains, and potentially costs lives. Understanding how health misinformation is transmitted is an urgent goal for researchers, social media platforms, health sectors, and policymakers to mitigate those ramifications. Deep learning methods have been deployed to predict the spread of misinformation. While achieving the state-of-the-art predictive performance, deep learning methods lack the interpretability due to their blackbox nature. To remedy this gap, this study proposes a novel interpretable deep learning approach, Generative Adversarial Network based Piecewise Wide and Attention Deep Learning (GAN-PiWAD), to predict health misinformation transmission in social media. Improving upon state-of-the-art interpretable methods, GAN-PiWAD captures the interactions among multi-modal data, offers unbiased estimation of the total effect of each feature, and models the dynamic total effect of each feature when its value varies. We select features according to social exchange theory and evaluate GAN-PiWAD on 4,445 misinformation videos. The proposed approach outperformed strong benchmarks. Interpretation of GAN-PiWAD indicates video description, negative video content, and channel credibility are key features that drive viral transmission of misinformation. This study contributes to IS with a novel interpretable deep learning method that is generalizable to understand other human decision factors. Our findings provide direct implications for social media platforms and policymakers to design proactive interventions to identify misinformation, control transmissions, and manage infodemics.