Low-cost accelerometers play a crucial role in modern society due to their advantages of small size, ease of integration, wearability, and mass production, making them widely applicable in automotive systems, aerospace, and wearable technology. However, this widely used sensor suffers from severe accuracy and range limitations. To this end, we propose a honed-energy regularized and optimal supervised GAN (HEROS-GAN), which transforms low-cost sensor signals into high-cost equivalents, thereby overcoming the precision and range limitations of low-cost accelerometers. Due to the lack of frame-level paired low-cost and high-cost signals for training, we propose an Optimal Transport Supervision (OTS), which leverages optimal transport theory to explore potential consistency between unpaired data, thereby maximizing supervisory information. Moreover, we propose a Modulated Laplace Energy (MLE), which injects appropriate energy into the generator to encourage it to break range limitations, enhance local changes, and enrich signal details. Given the absence of a dedicated dataset, we specifically establish a Low-cost Accelerometer Signal Enhancement Dataset (LASED) containing tens of thousands of samples, which is the first dataset serving to improve the accuracy and range of accelerometers and is released in Github. Experimental results demonstrate that a GAN combined with either OTS or MLE alone can surpass the previous signal enhancement SOTA methods by an order of magnitude. Integrating both OTS and MLE, the HEROS-GAN achieves remarkable results, which doubles the accelerometer range while reducing signal noise by two orders of magnitude, establishing a benchmark in the accelerometer signal processing.

Tissue semantic segmentation is one of the key tasks in computational pathology. To avoid the expensive and laborious acquisition of pixel-level annotations, a wide range of studies attempt to adopt the class activation map (CAM), a weakly-supervised learning scheme, to achieve pixel-level tissue segmentation. However, CAM-based methods are prone to suffer from under-activation and over-activation issues, leading to poor segmentation performance. To address this problem, we propose a novel weakly-supervised semantic segmentation framework for histopathological images based on image-mixing synthesis and consistency regularization, dubbed HisynSeg. Specifically, synthesized histopathological images with pixel-level masks are generated for fully-supervised model training, where two synthesis strategies are proposed based on Mosaic transformation and B\'ezier mask generation. Besides, an image filtering module is developed to guarantee the authenticity of the synthesized images. In order to further avoid the model overfitting to the occasional synthesis artifacts, we additionally propose a novel self-supervised consistency regularization, which enables the real images without segmentation masks to supervise the training of the segmentation model. By integrating the proposed techniques, the HisynSeg framework successfully transforms the weakly-supervised semantic segmentation problem into a fully-supervised one, greatly improving the segmentation accuracy. Experimental results on three datasets prove that the proposed method achieves a state-of-the-art performance. Code is available at https://github.com/Vison307/HisynSeg.

Scientific innovation is pivotal for humanity, and harnessing large language models (LLMs) to generate research ideas could transform discovery. However, existing LLMs often produce simplistic and repetitive suggestions due to their limited ability in acquiring external knowledge for innovation. To address this problem, we introduce an enhanced planning and search methodology designed to boost the creative potential of LLM-based systems. Our approach involves an iterative process to purposely plan the retrieval of external knowledge, progressively enriching the idea generation with broader and deeper insights. Validation through automated and human assessments indicates that our framework substantially elevates the quality of generated ideas, particularly in novelty and diversity. The number of unique novel ideas produced by our framework is 3.4 times higher than without it. Moreover, our method outperforms the current state-of-the-art, generating at least 2.5 times more top-rated ideas based on 170 seed papers in a Swiss Tournament evaluation.

As deep learning continues to evolve, the need for data efficiency becomes increasingly important. Considering labeling large datasets is both time-consuming and expensive, active learning (AL) provides a promising solution to this challenge by iteratively selecting the most informative subsets of examples to train deep neural networks, thereby reducing the labeling cost. However, the effectiveness of different AL algorithms can vary significantly across data scenarios, and determining which AL algorithm best fits a given task remains a challenging problem. This work presents the first differentiable AL strategy search method, named AutoAL, which is designed on top of existing AL sampling strategies. AutoAL consists of two neural nets, named SearchNet and FitNet, which are optimized concurrently under a differentiable bi-level optimization framework. For any given task, SearchNet and FitNet are iteratively co-optimized using the labeled data, learning how well a set of candidate AL algorithms perform on that task. With the optimal AL strategies identified, SearchNet selects a small subset from the unlabeled pool for querying their annotations, enabling efficient training of the task model. Experimental results demonstrate that AutoAL consistently achieves superior accuracy compared to all candidate AL algorithms and other selective AL approaches, showcasing its potential for adapting and integrating multiple existing AL methods across diverse tasks and domains. Code will be available at: https://github.com/haizailache999/AutoAL.

Correlating neuropathology with neuroimaging findings provides a multiscale view of pathologic changes in the human organ spanning the meso- to micro-scales, and is an emerging methodology expected to shed light on numerous disease states. To gain the most information from this multimodal, multiscale approach, it is desirable to identify precisely where a histologic tissue section was taken from within the organ in order to correlate with the tissue features in exactly the same organ region. Histology-to-organ registration poses an extra challenge, as any given histologic section can capture only a small portion of a human organ. Making use of the capabilities of state-of-the-art deep learning models, we unlock the potential to address and solve such intricate challenges. Therefore, we create the ATOM benchmark dataset, sourced from diverse institutions, with the primary objective of transforming this challenge into a machine learning problem and delivering outstanding outcomes that enlighten the biomedical community. The performance of our RegisMCAN model demonstrates the potential of deep learning to accurately predict where a subregion extracted from an organ image was obtained from within the overall 3D volume. The code and dataset can be found at: https://github.com/haizailache999/Image-Registration/tree/main

As attitude and motion sensing components, inertial sensors are widely used in various portable devices. But the severe errors of inertial sensors restrain their function, especially the trajectory recovery and semantic recognition. As a mainstream signal processing method, wavelet is hailed as the mathematical microscope of signal due to the plentiful and diverse wavelet basis functions. However, complicated noise types and application scenarios of inertial sensors make selecting wavelet basis perplexing. To this end, we propose a wavelet dynamic selection network (WDSNet), which intelligently selects the appropriate wavelet basis for variable inertial signals. In addition, existing deep learning architectures excel at extracting features from input data but neglect to learn the characteristics of target categories, which is essential to enhance the category awareness capability, thereby improving the selection of wavelet basis. Therefore, we propose a category representation mechanism (CRM), which enables the network to extract and represent category features without increasing trainable parameters. Furthermore, CRM transforms the common fully connected network into category representations, which provide closer supervision to the feature extractor than the far and trivial one-hot classification labels. We call this process of imposing interpretability on a network and using it to supervise the feature extractor the feature supervision mechanism, and its effectiveness is demonstrated experimentally and theoretically in this paper. The enhanced inertial signal can perform impracticable tasks with regard to the original signal, such as trajectory reconstruction. Both quantitative and visual results show that WDSNet outperforms the existing methods. Remarkably, WDSNet, as a weakly-supervised method, achieves the state-of-the-art performance of all the compared fully-supervised methods.

Biomarker detection is an indispensable part in the diagnosis and treatment of low-grade glioma (LGG). However, current LGG biomarker detection methods rely on expensive and complex molecular genetic testing, for which professionals are required to analyze the results, and intra-rater variability is often reported. To overcome these challenges, we propose an interpretable deep learning pipeline, a Multi-Biomarker Histomorphology Discoverer (Multi-Beholder) model based on the multiple instance learning (MIL) framework, to predict the status of five biomarkers in LGG using only hematoxylin and eosin-stained whole slide images and slide-level biomarker status labels. Specifically, by incorporating the one-class classification into the MIL framework, accurate instance pseudo-labeling is realized for instance-level supervision, which greatly complements the slide-level labels and improves the biomarker prediction performance. Multi-Beholder demonstrates superior prediction performance and generalizability for five LGG biomarkers (AUROC=0.6469-0.9735) in two cohorts (n=607) with diverse races and scanning protocols. Moreover, the excellent interpretability of Multi-Beholder allows for discovering the quantitative and qualitative correlations between biomarker status and histomorphology characteristics. Our pipeline not only provides a novel approach for biomarker prediction, enhancing the applicability of molecular treatments for LGG patients but also facilitates the discovery of new mechanisms in molecular functionality and LGG progression.

The success of Computer Vision (CV) relies heavily on manually annotated data. However, it is prohibitively expensive to annotate images in key domains such as healthcare, where data labeling requires significant domain expertise and cannot be easily delegated to crowd workers. To address this challenge, we propose a neuro-symbolic approach called Rapid, which infers image labeling rules from a small amount of labeled data provided by domain experts and automatically labels unannotated data using the rules. Specifically, Rapid combines pre-trained CV models and inductive logic learning to infer the logic-based labeling rules. Rapid achieves a labeling accuracy of 83.33% to 88.33% on four image labeling tasks with only 12 to 39 labeled samples. In particular, Rapid significantly outperforms finetuned CV models in two highly specialized tasks. These results demonstrate the effectiveness of Rapid in learning from small data and its capability to generalize among different tasks. Code and our dataset are publicly available at https://github.com/Neural-Symbolic-Image-Labeling/

Body Mass Index (BMI), age, height and weight are important indicators of human health conditions, which can provide useful information for plenty of practical purposes, such as health care, monitoring and re-identification. Most existing methods of health indicator prediction mainly use front-view body or face images. These inputs are hard to be obtained in daily life and often lead to the lack of robustness for the models, considering their strict requirements on view and pose. In this paper, we propose to employ gait videos to predict health indicators, which are more prevalent in surveillance and home monitoring scenarios. However, the study of health indicator prediction from gait videos using deep learning was hindered due to the small amount of open-sourced data. To address this issue, we analyse the similarity and relationship between pose estimation and health indicator prediction tasks, and then propose a paradigm enabling deep learning for small health indicator datasets by pre-training on the pose estimation task. Furthermore, to better suit the health indicator prediction task, we bring forward Global-Local Aware aNd Centrosymmetric Encoder (GLANCE) module. It first extracts local and global features by progressive convolutions and then fuses multi-level features by a centrosymmetric double-path hourglass structure in two different ways. Experiments demonstrate that the proposed paradigm achieves state-of-the-art results for predicting health indicators on MoVi, and that the GLANCE module is also beneficial for pose estimation on 3DPW.

Feature selection is among the most important components because it not only helps enhance the classification accuracy, but also or even more important provides potential biomarker discovery. However, traditional multivariate methods is likely to obtain unstable and unreliable results in case of an extremely high dimensional feature space and very limited training samples, where the features are often correlated or redundant. In order to improve the stability, generalization and interpretations of the discovered potential biomarker and enhance the robustness of the resultant classifier, the redundant but informative features need to be also selected. Therefore we introduced a novel feature selection method which combines a recent implementation of the stability selection approach and the elastic net approach. The advantage in terms of better control of false discoveries and missed discoveries of our approach, and the resulted better interpretability of the obtained potential biomarker is verified in both synthetic and real fMRI experiments. In addition, we are among the first to demonstrate the robustness of feature selection benefiting from the incorporation of stability selection and also among the first to demonstrate the possible unrobustness of the classical univariate two-sample t-test method. Specifically, we show the robustness of our feature selection results in existence of noisy (wrong) training labels, as well as the robustness of the resulted classifier based on our feature selection results in the existence of data variation, demonstrated by a multi-center attention-deficit/hyperactivity disorder (ADHD) fMRI data.