Large Language Models (LLMs) have demonstrated impressive capabilities on a broad array of NLP tasks, but their tendency to produce hallucinations$\unicode{x2013}$plausible-sounding but factually incorrect content$\unicode{x2013}$poses severe challenges in high-stakes domains. Existing hallucination detection methods either bear the computational cost of multiple inference passes or sacrifice accuracy for efficiency with single-pass approaches, neither of which is ideal in resource-constrained environments such as edge devices. We propose the Shannon Entropy Distribution Hallucination Detector (ShED-HD), a novel hallucination detection framework that bridges this gap by classifying sequence-level entropy patterns using a lightweight BiLSTM architecture with single-headed attention. In contrast to prior approaches, ShED-HD efficiently detects distinctive uncertainty patterns across entire output sequences, preserving contextual awareness. Through in-depth evaluation on three datasets (BioASQ, TriviaQA, and Jeopardy Questions), we show that ShED-HD significantly outperforms other computationally efficient approaches in the out-of-distribution setting, while achieving comparable performance in the in-distribution setting. ShED-HD facilitates hallucination detection that is low-cost, accurate, and generalizable, improving the credibility of content generated by LLMs in resource-constrained environments where trustworthy AI functionality is crucial.

The thrombotic microangiopathies (TMAs) manifest in renal biopsy histology with a broad spectrum of acute and chronic findings. Precise diagnostic criteria for a renal biopsy diagnosis of TMA are missing. As a first step towards a machine learning- and computer vision-based analysis of wholes slide images from renal biopsies, we trained a segmentation model for the decisive diagnostic kidney tissue compartments artery, arteriole, glomerulus on a set of whole slide images from renal biopsies with TMAs and Mimickers (distinct diseases with a similar nephropathological appearance as TMA like severe benign nephrosclerosis, various vasculitides, Bevacizumab-plug glomerulopathy, arteriolar light chain deposition disease). Our segmentation model combines a U-Net-based tissue detection with a Shifted windows-transformer architecture to reach excellent segmentation results for even the most severely altered glomeruli, arterioles and arteries, even on unseen staining domains from a different nephropathology lab. With accurate automatic segmentation of the decisive renal biopsy compartments in human renal vasculopathies, we have laid the foundation for large-scale compartment-specific machine learning and computer vision analysis of renal biopsy repositories with TMAs.