Ensuring the safety of generative MLLMs is absolutely crucial in order to prevent harm, build trust, address ethical concerns, and enable their responsible deployment in real-world applications. Our results demonstrate that Granite Vision performs almost at par with baselines (despite being the lightest MLLM in the comparison pool) for VLM-as-a-Judge task. Notably, the addition of Safety Vectors to Granite Vision leads to a significant improvement in safety classification performance. We do acknowledge that further work needs to be done to improve high-level reasoning and correct occasional incorrect outputs to improve reliability in sensitive tasks, which require nuanced classification. To address these, we will incorporate more reasoning-focused and structure-related data into the training process in the future. In addition, we showed in this paper that finding safety vectors (SVs) in Granite Vision's attention heads led to significant improvements when safety tasks were reformulated as classification problems. Current reliance for SVs is on few-shot samples which are informative but may have limited scope in terms of capturing the range of possible safety issues that can be encountered. To further improve the model's ability to identify and address all safety concerns, we plan to investigate scaling up SVs using more training data in future research.

While some metrics cover clinical entities and their relations[9, 11], generally Several evaluation metrics have been developed recently to scoring metrics do not explicitly capture the textual mention automatically assess the quality of generative AI reports for differences in the anatomy, laterality and severity. Further, chest radiographs based only on textual information using phrasal grounding of the findings in terms of anatomical localization lexical, semantic, or clinical named entity recognition methods. in images is not exploited in the quality scoring. In this paper, we develop a new method of report quality In this paper, we propose a metric that captures both finegrained evaluation by first extracting fine-grained finding patterns textual descriptions of findings as well as their phrasal capturing the location, laterality, and severity of a large number grounding information in terms of anatomical locations in images. of clinical findings. We then performed phrasal grounding We present results that compare this evaluation metric to localize their associated anatomical regions on chest radiograph to other textual metrics on a gold standard dataset derived images. The textual and visual measures are then combined from MIMIC collection of chest X-rays and validated reports, to rate the quality of the generated reports. We present to show its robustness and sensitivity to factual errors.

Content-addressable memories such as Modern Hopfield Networks (MHN) have been studied as mathematical models of auto-association and storage/retrieval in the human declarative memory, yet their practical use for large-scale content storage faces challenges. Chief among them is the occurrence of meta-stable states, particularly when handling large amounts of high dimensional content. This paper introduces Hopfield Encoding Networks (HEN), a framework that integrates encoded neural representations into MHNs to improve pattern separability and reduce meta-stable states. We show that HEN can also be used for retrieval in the context of hetero association of images with natural language queries, thus removing the limitation of requiring access to partial content in the same domain. Experimental results demonstrate substantial reduction in meta-stable states and increased storage capacity while still enabling perfect recall of a significantly larger number of inputs advancing the practical utility of associative memory networks for real-world tasks.

Machine learning (ML), the process of leveraging algorithms and optimization to infer strategies for solving learning tasks, has enabled some of the greatest developments in artificial intelligence (AI) in the last decade, enabling the automated segmentation or class identification of images, the ability to answer nearly any text-based question, and the ability to generate images never seen before. In biomedical research, many of these ML models are quickly being applied to medical images and decision support systems in conjunction with a significant shift from traditional and statistical methods to increasing application of deep learning models. At the same time, the importance of both plentiful and well-curated data has become better understood, coinciding as of the time of writing this article with the incredible premise of OpenAI's ChatGPT and GPT-4 engines as well as other generative AI models which are trained on a vast, well-curated, and diverse array of content from across the internet [1]. As more data has become available, a wider selection of datasets containing more than one modality has also enabled growth in the multimodal research sphere. Multimodal data is intrinsic to biomedical research and clinical care.

With the emergence of multimodal electronic health records, the evidence for an outcome may be captured across multiple modalities ranging from clinical to imaging and genomic data. Predicting outcomes effectively requires fusion frameworks capable of modeling fine-grained and multi-faceted complex interactions between modality features within and across patients. We develop an innovative fusion approach called MaxCorr MGNN that models non-linear modality correlations within and across patients through Hirschfeld-Gebelein-Renyi maximal correlation (MaxCorr) embeddings, resulting in a multi-layered graph that preserves the identities of the modalities and patients. We then design, for the first time, a generalized multi-layered graph neural network (MGNN) for task-informed reasoning in multi-layered graphs, that learns the parameters defining patient-modality graph connectivity and message passing in an end-to-end fashion. We evaluate our model an outcome prediction task on a Tuberculosis (TB) dataset consistently outperforming several state-of-the-art neural, graph-based and traditional fusion techniques.

Visual Question Answering (VQA) becomes one of the most active research problems in the medical imaging domain. A well-known VQA challenge is the intrinsic diversity between the image and text modalities, and in the medical VQA task, there is another critical problem relying on the limited size of labelled image-question-answer data. In this study we propose an encoder-decoder framework that leverages the image-text joint representation learned from large-scaled medical image-caption data and adapted to the small-sized medical VQA task. The encoder embeds across the image-text dual modalities with self-attention mechanism and is independently pre-trained on the large-scaled medical image-caption dataset by multiple self-supervised learning tasks. Then the decoder is connected to the top of the encoder and fine-tuned using the small-sized medical VQA dataset. The experiment results present that our proposed method achieves better performance comparing with the baseline and SOTA methods.

Recent genome-wide association studies (GWAS) have been successful in identifying associations between genetic variants and simple cardiac parameters derived from cardiac magnetic resonance (CMR) images. However, the emergence of big databases including genetic data linked to CMR, facilitates investigation of more nuanced patterns of shape variability. Here, we propose a new framework for gene discovery entitled Unsupervised Phenotype Ensembles (UPE). UPE builds a redundant yet highly expressive representation by pooling a set of phenotypes learned in an unsupervised manner, using deep learning models trained with different hyperparameters. These phenotypes are then analyzed via (GWAS), retaining only highly confident and stable associations across the ensemble. We apply our approach to the UK Biobank database to extract left-ventricular (LV) geometric features from image-derived three-dimensional meshes. We demonstrate that our approach greatly improves the discoverability of genes influencing LV shape, identifying 11 loci with study-wide significance and 8 with suggestive significance. We argue that our approach would enable more extensive discovery of gene associations with image-derived phenotypes for other organs or image modalities.

The availability of multi-modality datasets provides a unique opportunity to characterize the same object of interest using multiple viewpoints more comprehensively. In this work, we investigate the use of canonical correlation analysis (CCA) and penalized variants of CCA (pCCA) for the fusion of two modalities. We study a simple graphical model for the generation of two-modality data. We analytically show that, with known model parameters, posterior mean estimators that jointly use both modalities outperform arbitrary linear mixing of single modality posterior estimators in latent variable prediction. Penalized extensions of CCA (pCCA) that incorporate domain knowledge can discover correlations with high-dimensional, low-sample data, whereas traditional CCA is inapplicable. To facilitate the generation of multi-dimensional embeddings with pCCA, we propose two matrix deflation schemes that enforce desirable properties exhibited by CCA. We propose a two-stage prediction pipeline using pCCA embeddings generated with deflation for latent variable prediction by combining all the above. On simulated data, our proposed model drastically reduces the mean-squared error in latent variable prediction. When applied to publicly available histopathology data and RNA-sequencing data from The Cancer Genome Atlas (TCGA) breast cancer patients, our model can outperform principal components analysis (PCA) embeddings of the same dimension in survival prediction.

Chest radiographs are the most common diagnostic exam in emergency rooms and intensive care units today. Recently, a number of researchers have begun working on large chest X-ray datasets to develop deep learning models for recognition of a handful of coarse finding classes such as opacities, masses and nodules. In this paper, we focus on extracting and learning fine-grained labels for chest X-ray images. Specifically we develop a new method of extracting fine-grained labels from radiology reports by combining vocabulary-driven concept extraction with phrasal grouping in dependency parse trees for association of modifiers with findings. A total of 457 fine-grained labels depicting the largest spectrum of findings to date were selected and sufficiently large datasets acquired to train a new deep learning model designed for fine-grained classification. We show results that indicate a highly accurate label extraction process and a reliable learning of fine-grained labels. The resulting network, to our knowledge, is the first to recognize fine-grained descriptions of findings in images covering over nine modifiers including laterality, location, severity, size and appearance.

Due to advances in machine learning and artificial intelligence (AI), a new role is emerging for machines as intelligent assistants to radiologists in their clinical workflows. But what systematic clinical thought processes are these machines using? Are they similar enough to those of radiologists to be trusted as assistants? A live demonstration of such a technology was conducted at the 2016 Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA). The demonstration was presented in the form of a question-answering system that took a radiology multiple choice question and a medical image as inputs. The AI system then demonstrated a cognitive workflow, involving text analysis, image analysis, and reasoning, to process the question and generate the most probable answer. A post demonstration survey was made available to the participants who experienced the demo and tested the question answering system. Of the reported 54,037 meeting registrants, 2,927 visited the demonstration booth, 1,991 experienced the demo, and 1,025 completed a post-demonstration survey. In this paper, the methodology of the survey is shown and a summary of its results are presented. The results of the survey show a very high level of receptiveness to cognitive computing technology and artificial intelligence among radiologists.