In the astronomical observation field, determining the allocation of observation resources of the telescope array and planning follow-up observations for targets of opportunity (ToOs) are indispensable components of astronomical scientific discovery. This problem is computationally challenging, given the online observation setting and the abundance of time-varying factors that can affect whether an observation can be conducted. This paper presents ROARS, a reinforcement learning approach for online astronomical resource-constrained scheduling. To capture the structure of the astronomical observation scheduling, we depict every schedule using a directed acyclic graph (DAG), illustrating the dependency of timing between different observation tasks within the schedule. Deep reinforcement learning is used to learn a policy that can improve the feasible solution by iteratively local rewriting until convergence. It can solve the challenge of obtaining a complete solution directly from scratch in astronomical observation scenarios, due to the high computational complexity resulting from numerous spatial and temporal constraints. A simulation environment is developed based on real-world scenarios for experiments, to evaluate the effectiveness of our proposed scheduling approach. The experimental results show that ROARS surpasses 5 popular heuristics, adapts to various observation scenarios and learns effective strategies with hindsight.

Off-road environments present significant challenges for autonomous ground vehicles due to the absence of structured roads and the presence of complex obstacles, such as uneven terrain, vegetation, and occlusions. Traditional perception algorithms, designed primarily for structured environments, often fail under these conditions, leading to inaccurate traversability estimations. In this paper, ORDformer, a novel multimodal method that combines LiDAR point clouds with monocular images, is proposed to generate dense traversable occupancy predictions from a forward-facing perspective. By integrating multimodal data, environmental feature extraction is enhanced, which is crucial for accurate occupancy estimation in complex terrains. Furthermore, RELLIS-OCC, a dataset with 3D traversable occupancy annotations, is introduced, incorporating geometric features such as step height, slope, and unevenness. Through a comprehensive analysis of vehicle obstacle-crossing conditions and the incorporation of vehicle body structure constraints, four traversability cost labels are generated: lethal, medium-cost, low-cost, and free. Experimental results demonstrate that ORDformer outperforms existing approaches in 3D traversable area recognition, particularly in off-road environments with irregular geometries and partial occlusions. Specifically, ORDformer achieves over a 20\% improvement in scene completion IoU compared to other models. The proposed framework is scalable and adaptable to various vehicle platforms, allowing for adjustments to occupancy grid parameters and the integration of advanced dynamic models for traversability cost estimation.

The fields of therapeutic application and drug research and development (R&D) both face substantial challenges, i.e., the therapeutic domain calls for more treatment alternatives, while numerous promising pre-clinical drugs have failed in clinical trials. One of the reasons is the inadequacy of Cross-drug Response Evaluation (CRE) during the late stages of drug R&D. Although in-silico CRE models bring a promising solution, existing methodologies are restricted to early stages of drug R&D, such as target and cell-line levels, offering limited improvement to clinical success rates. Herein, we introduce DeepCRE, a pioneering AI model designed to predict CRE effectively in the late stages of drug R&D. DeepCRE outperforms the existing best models by achieving an average performance improvement of 17.7% in patient-level CRE, and a 5-fold increase in indication-level CRE, facilitating more accurate personalized treatment predictions and better pharmaceutical value assessment for indications, respectively. Furthermore, DeepCRE has identified a set of six drug candidates that show significantly greater effectiveness than a comparator set of two approved drugs in 5/8 colorectal cancer organoids. This demonstrates the capability of DeepCRE to systematically uncover a spectrum of drug candidates with enhanced therapeutic effects, highlighting its potential to transform drug R&D.

We introduce MABe22, a large-scale, multi-agent video and trajectory benchmark to assess the quality of learned behavior representations. This dataset is collected from a variety of biology experiments, and includes triplets of interacting mice (4.7 million frames video+pose tracking data, 10 million frames pose only), symbiotic beetle-ant interactions (10 million frames video data), and groups of interacting flies (4.4 million frames of pose tracking data). Accompanying these data, we introduce a panel of real-life downstream analysis tasks to assess the quality of learned representations by evaluating how well they preserve information about the experimental conditions (e.g. strain, time of day, optogenetic stimulation) and animal behavior. We test multiple state-of-the-art self-supervised video and trajectory representation learning methods to demonstrate the use of our benchmark, revealing that methods developed using human action datasets do not fully translate to animal datasets. We hope that our benchmark and dataset encourage a broader exploration of behavior representation learning methods across species and settings.

Deep learning (DL) has been increasingly applied to a variety of domains. The programming paradigm shift from traditional systems to DL systems poses unique challenges in engineering DL systems. Performance is one of the challenges, and performance bugs(PBs) in DL systems can cause severe consequences such as excessive resource consumption and financial loss. While bugs in DL systems have been extensively investigated, PBs in DL systems have hardly been explored. To bridge this gap, we present the first comprehensive study to characterize symptoms, root causes, and introducing and exposing stages of PBs in DL systems developed in TensorFLow and Keras, with a total of 238 PBs collected from 225 StackOverflow posts. Our findings shed light on the implications on developing high performance DL systems, and detecting and localizing PBs in DL systems. We also build the first benchmark of 56 PBs in DL systems, and assess the capability of existing approaches in tackling them. Moreover, we develop a static checker DeepPerf to detect three types of PBs, and identify 488 new PBs in 130 GitHub projects.62 and 18 of them have been respectively confirmed and fixed by developers.

Dynamic ensembling of classifiers is an effective approach in processing label-imbalanced classifications. However, in dynamic ensemble methods, the combination of classifiers is usually determined by the local competence and conventional regularization methods are difficult to apply, leaving the technique prone to overfitting. In this paper, focusing on the binary label-imbalanced classification field, a novel method of Adaptive Ensemble of classifiers with Regularization (AER) has been proposed. The method deals with the overfitting problem from a perspective of implicit regularization. Specifically, it leverages the properties of Stochastic Gradient Descent (SGD) to obtain the solution with the minimum norm to achieve regularization, and interpolates ensemble weights via the global geometry of data to further prevent overfitting. The method enjoys a favorable time and memory complexity, and theoretical proofs show that algorithms implemented with AER paradigm have time and memory complexities upper-bounded by their original implementations. Furthermore, the proposed AER method is tested with a specific implementation based on Gradient Boosting Machine (XGBoost) on the three datasets: UCI Bioassay, KEEL Abalone19, and a set of GMM-sampled artificial dataset. Results show that the proposed AER algorithm can outperform the major existing algorithms based on multiple metrics, and Mcnemar's tests are applied to validate performance superiorities. To summarize, this work complements regularization for dynamic ensemble methods and develops an algorithm superior in grasping both the global and local geometry of data to alleviate overfitting in imbalanced data classification.