Deep learning-based drug-target interaction (DTI) prediction methods have demonstrated strong performance; however, real-world applicability remains constrained by limited data diversity and modeling complexity. To address these challenges, we propose SCOPE-DTI, a unified framework combining a large-scale, balanced semi-inductive human DTI dataset with advanced deep learning modeling. Constructed from 13 public repositories, the SCOPE dataset expands data volume by up to 100-fold compared to common benchmarks such as the Human dataset. The SCOPE model integrates three-dimensional protein and compound representations, graph neural networks, and bilinear attention mechanisms to effectively capture cross domain interaction patterns, significantly outperforming state-of-the-art methods across various DTI prediction tasks. Additionally, SCOPE-DTI provides a user-friendly interface and database. We further validate its effectiveness by experimentally identifying anticancer targets of Ginsenoside Rh1. By offering comprehensive data, advanced modeling, and accessible tools, SCOPE-DTI accelerates drug discovery research.

Despite recent breakthroughs in reasoning-enhanced large language models (LLMs) like DeepSeek-R1, incorporating inference-time reasoning into machine translation (MT), where human translators naturally employ structured, multi-layered reasoning chain-of-thoughts (CoTs), is yet underexplored. Existing methods either design a fixed CoT tailored for a specific MT sub-task (e.g., literature translation), or rely on synthesizing CoTs unaligned with humans, limiting their adaptability to diverse translation scenarios. This paper introduces R1-Translator (R1-T1), a novel framework to achieve inference-time reasoning for general MT via reinforcement learning (RL) with human-aligned CoTs comprising six common patterns. Our approach pioneers three innovations: (1) extending reasoning-based translation beyond MT sub-tasks to six languages and diverse tasks (e.g., legal/medical domain adaptation, idiom resolution); (2) formalizing six expert-curated CoT templates that mirror hybrid human strategies like context-aware paraphrasing and back translation; and (3) enabling self-evolving CoT discovery through RL. Experimental results indicate a steady translation performance improvement in 11 languages and 40 translation directions on Flores-101 test set, especially on the languages unseen from training.

The scarcity of non-English data limits the development of non-English large language models (LLMs). Transforming English-centric LLMs to non-English has been identified as an effective and resource-efficient method. Previous works start from base LLMs and perform knowledge distillation (KD) with data generated by stronger LLMs, e.g. GPT-4. Compared to base LLMs, chat LLMs are further optimized for advanced abilities, e.g. multi-turn conversation and human preference alignment, and thus more powerful in both helpfulness and safety. However, transforming a chat LLM involves two critical issues: (1) How can we effectively transfer advanced abilities without their supervised data? (2) How can we prevent the original knowledge from catastrophic forgetting during transformation? We target these issues by introducing a simple framework called TransLLM. For the first issue, TransLLM divides the transfer problem into some common sub-tasks with the translation chain-of-thought, which uses the translation as the bridge between English and non-English step-by-step. We further enhance the performance of sub-tasks with publicly available data. For the second issue, we propose a method comprising two synergistic components: low-rank adaptation for training to maintain the original LLM parameters, and recovery KD, which utilizes data generated by the chat LLM itself to recover the original knowledge from the frozen parameters. In the experiments, we transform the LLaMA-2-chat-7B to the Thai language. Our method, using only single-turn data, outperforms strong baselines and ChatGPT on multi-turn benchmark MT-bench. Furthermore, our method, without safety data, rejects more harmful queries of safety benchmark AdvBench than both ChatGPT and GPT-4.

Joint analysis of multi-omic single-cell data across cohorts has significantly enhanced the comprehensive analysis of cellular processes. However, most of the existing approaches for this purpose require access to samples with complete modality availability, which is impractical in many real-world scenarios. In this paper, we propose (Single-Cell Cross-Cohort Cross-Category) integration, a novel framework that learns unified cell representations under domain shift without requiring full-modality reference samples. Our generative approach learns rich cross-modal and cross-domain relationships that enable imputation of these missing modalities. Through experiments on real-world multi-omic datasets, we demonstrate that offers a robust solution to single-cell tasks such as cell type clustering, cell type classification, and feature imputation.

Pre-training has been investigated to improve the efficiency and performance of training neural operators in data-scarce settings. However, it is largely in its infancy due to the inherent complexity and diversity, such as long trajectories, multiple scales and varying dimensions of partial differential equations (PDEs) data. In this paper, we present a new auto-regressive denoising pre-training strategy, which allows for more stable and efficient pre-training on PDE data and generalizes to various downstream tasks. Moreover, by designing a flexible and scalable model architecture based on Fourier attention, we can easily scale up the model for large-scale pre-training. We train our PDE foundation model with up to 0.5B parameters on 10+ PDE datasets with more than 100k trajectories. Extensive experiments show that we achieve SOTA on these benchmarks and validate the strong generalizability of our model to significantly enhance performance on diverse downstream PDE tasks like 3D data. Code is available at \url{https://github.com/thu-ml/DPOT}.

Machine Translation Quality Estimation (MTQE) is the task of estimating the quality of machine-translated text in real time without the need for reference translations, which is of great importance for the development of MT. After two decades of evolution, QE has yielded a wealth of results. This article provides a comprehensive overview of QE datasets, annotation methods, shared tasks, methodologies, challenges, and future research directions. It begins with an introduction to the background and significance of QE, followed by an explanation of the concepts and evaluation metrics for word-level QE, sentence-level QE, document-level QE, and explainable QE. The paper categorizes the methods developed throughout the history of QE into those based on handcrafted features, deep learning, and Large Language Models (LLMs), with a further division of deep learning-based methods into classic deep learning and those incorporating pre-trained language models (LMs). Additionally, the article details the advantages and limitations of each method and offers a straightforward comparison of different approaches. Finally, the paper discusses the current challenges in QE research and provides an outlook on future research directions.

Physics-informed neural networks (PINNs) have shown promise in solving various partial differential equations (PDEs). However, training pathologies have negatively affected the convergence and prediction accuracy of PINNs, which further limits their practical applications. In this paper, we propose to use condition number as a metric to diagnose and mitigate the pathologies in PINNs. Inspired by classical numerical analysis, where the condition number measures sensitivity and stability, we highlight its pivotal role in the training dynamics of PINNs. We prove theorems to reveal how condition number is related to both the error control and convergence of PINNs. Subsequently, we present an algorithm that leverages preconditioning to improve the condition number. Evaluations of 18 PDE problems showcase the superior performance of our method. Significantly, in 7 of these problems, our method reduces errors by an order of magnitude. These empirical findings verify the critical role of the condition number in PINNs' training.

End-to-end automatic speech recognition (ASR) systems often struggle to recognize rare name entities, such as personal names, organizations, and terminologies not frequently encountered in the training data. This paper presents Contextual Biasing Whisper (CB-Whisper), a novel ASR system based on OpenAI's Whisper model that can recognize user-defined name entities by performing open-vocabulary keyword-spotting (OV-KWS) using the hidden states of Whisper encoder. The recognized entities are used as prompts for the Whisper decoder. We first propose a multitask training approach with OV-KWS and ASR tasks to optimize the model. Experiments show that this approach substantially improves the entity recalls compared to the original Whisper model on Chinese Aishell hot word subsets and two internal code-switch test sets. However, we observed a slight increase in mixed-error-rate (MER) on internal test sets due to catastrophic forgetting. To address this problem and use different sizes of the Whisper model without finetuning, we propose to use OV-KWS as a separate module and construct a spoken form prompt to prevent hallucination. The OV-KWS module consistently improves MER and Entity Recall for whisper-small, medium, and large models.

Mapping speech tokens to the same feature space as text tokens has become the paradigm for the integration of speech modality into decoder-only large language models (LLMs). An alternative approach is to use an encoder-decoder architecture that incorporates speech features through cross-attention. This approach, however, has received less attention in the literature. In this work, we connect the Whisper encoder with ChatGLM3 and provide in-depth comparisons of these two approaches using Chinese automatic speech recognition (ASR) and name entity recognition (NER) tasks. We evaluate them not only by conventional metrics like the F1 score but also by a novel fine-grained taxonomy of ASR-NER errors. Our experiments reveal that encoder-decoder architecture outperforms decoder-only architecture with a short context, while decoder-only architecture benefits from a long context as it fully exploits all layers of the LLM. By using LLM, we significantly reduced the entity omission errors and improved the entity ASR accuracy compared to the Conformer baseline. Additionally, we obtained a state-of-the-art (SOTA) F1 score of 0.805 on the AISHELL-NER test set by using chain-of-thought (CoT) NER which first infers long-form ASR transcriptions and then predicts NER labels.

Error correction techniques have been used to refine the output sentences from automatic speech recognition (ASR) models and achieve a lower word error rate (WER). Previous works usually adopt end-to-end models and has strong dependency on Pseudo Paired Data and Original Paired Data. But when only pre-training on Pseudo Paired Data, previous models have negative effect on correction. While fine-tuning on Original Paired Data, the source side data must be transcribed by a well-trained ASR model, which takes a lot of time and not universal. In this paper, we propose UCorrect, an unsupervised Detector-Generator-Selector framework for ASR Error Correction. UCorrect has no dependency on the training data mentioned before. The whole procedure is first to detect whether the character is erroneous, then to generate some candidate characters and finally to select the most confident one to replace the error character. Experiments on the public AISHELL-1 dataset and WenetSpeech dataset show the effectiveness of UCorrect for ASR error correction: 1) it achieves significant WER reduction, achieves 6.83\% even without fine-tuning and 14.29\% after fine-tuning; 2) it outperforms the popular NAR correction models by a large margin with a competitive low latency; and 3) it is an universal method, as it reduces all WERs of the ASR model with different decoding strategies and reduces all WERs of ASR models trained on different scale datasets.