The necessity of achieving an effective balance between minimizing the losses associated with restricting human mobility and ensuring hospital capacity has gained significant attention in the aftermath of COVID-19. Reinforcement learning (RL)-based strategies for human mobility management have recently advanced in addressing the dynamic evolution of cities and epidemics; however, they still face challenges in achieving coordinated control at the township level and adapting to cities of varying scales. To address the above issues, we propose a multi-agent RL approach that achieves Pareto optimality in managing hospital capacity and human mobility (H2-MARL), applicable across cities of different scales. We first develop a township-level infection model with online-updatable parameters to simulate disease transmission and construct a city-wide dynamic spatiotemporal epidemic simulator. On this basis, H2-MARL is designed to treat each division as an agent, with a trade-off dual-objective reward function formulated and an experience replay buffer enriched with expert knowledge built. To evaluate the effectiveness of the model, we construct a township-level human mobility dataset containing over one billion records from four representative cities of varying scales. Extensive experiments demonstrate that H2-MARL has the optimal dual-objective trade-off capability, which can minimize hospital capacity strain while minimizing human mobility restriction loss. Meanwhile, the applicability of the proposed model to epidemic control in cities of varying scales is verified, which showcases its feasibility and versatility in practical applications.

Accurate tissue segmentation in fetal brain MRI remains challenging due to the dynamically changing anatomical anatomy and contrast during fetal development. To enhance segmentation accuracy throughout gestation, we introduced AtlasSeg, a dual-U-shape convolution network incorporating gestational age (GA) specific information as guidance. By providing a publicly available fetal brain atlas with segmentation label at the corresponding GA, AtlasSeg effectively extracted the contextual features of age-specific patterns in atlas branch and generated tissue segmentation in segmentation branch. Multi-scale attentive atlas feature fusions were constructed in all stages during encoding and decoding, giving rise to a dual-U-shape network to assist feature flow and information interactions between two branches. AtlasSeg outperformed six well-known segmentation networks in both our internal fetal brain MRI dataset and the external FeTA dataset. Ablation experiments demonstrate the efficiency of atlas guidance and the attention mechanism. The proposed AtlasSeg demonstrated superior segmentation performance against other convolution networks with higher segmentation accuracy, and may facilitate fetal brain MRI analysis in large-scale fetal brain studies.

Composite materials with 3D architectures are desirable in a variety of applications for the capability of tailoring their properties to meet multiple functional requirements. By the arrangement of materials' internal components, structure design is of great significance in tuning the properties of the composites. However, most of the composite structures are proposed by empirical designs following existing patterns. Hindered by the complexity of 3D structures, it is hard to extract customized structures with multiple desired properties from large design space. Here we report a multi-objective driven Wasserstein generative adversarial network (MDWGAN) to implement inverse designs of 3D composite structures according to given geometrical, structural and mechanical requirements. Our framework consists a GAN based network which generates 3D composite structures possessing with similar geometrical and structural features to the target dataset. Besides, multiple objectives are introduced to our framework for the control of mechanical property and isotropy of the composites. Real time calculation of the properties in training iterations is achieved by an accurate surrogate model. We constructed a small and concise dataset to illustrate our framework. With multiple objectives combined by their weight, and the 3D-GAN act as a soft constraint, our framework is proved to be capable of tuning the properties of the generated composites in multiple aspects, while keeping the selected features of different kinds of structures. The feasibility on small dataset and potential scalability on objectives of other properties make our work a novel, effective approach to provide fast, experience free composite structure designs for various functional materials.