Clinical oncology generates vast, unstructured data that often contain inconsistencies, missing information, and ambiguities, making it difficult to extract reliable insights for data-driven decision-making. General-purpose large language models (LLMs) struggle with these challenges due to their lack of domain-specific reasoning, including specialized clinical terminology, context-dependent interpretations, and multi-modal data integration. We address these issues with an oncology-specialized, efficient, and adaptable NLP framework that combines instruction tuning, retrieval-augmented generation (RAG), and graph-based knowledge integration. Our lightweight models prove effective at oncology-specific tasks, such as named entity recognition (e.g., identifying cancer diagnoses), entity linking (e.g., linking entities to standardized ontologies), TNM staging, document classification (e.g., cancer subtype classification from pathology reports), and treatment response prediction. Our framework emphasizes adaptability and resource efficiency. We include minimal German instructions, collected at the University Hospital Zurich (USZ), to test whether small amounts of non-English language data can effectively transfer knowledge across languages. This approach mirrors our motivation for lightweight models, which balance strong performance with reduced computational costs, making them suitable for resource-limited healthcare settings. We validated our models on oncology datasets, demonstrating strong results in named entity recognition, relation extraction, and document classification.

Capturing subtle speech disruptions across the psychosis spectrum is challenging because of the inherent variability in speech patterns. This variability reflects individual differences and the fluctuating nature of symptoms in both clinical and non-clinical populations. Accounting for uncertainty in speech data is essential for predicting symptom severity and improving diagnostic precision. Speech disruptions characteristic of psychosis appear across the spectrum, including in non-clinical individuals. We develop an uncertainty-aware model integrating acoustic and linguistic features to predict symptom severity and psychosis-related traits. Quantifying uncertainty in specific modalities allows the model to address speech variability, improving prediction accuracy. We analyzed speech data from 114 participants, including 32 individuals with early psychosis and 82 with low or high schizotypy, collected through structured interviews, semi-structured autobiographical tasks, and narrative-driven interactions in German. The model improved prediction accuracy, reducing RMSE and achieving an F1-score of 83% with ECE = 4.5e-2, showing robust performance across different interaction contexts. Uncertainty estimation improved model interpretability by identifying reliability differences in speech markers such as pitch variability, fluency disruptions, and spectral instability. The model dynamically adjusted to task structures, weighting acoustic features more in structured settings and linguistic features in unstructured contexts. This approach strengthens early detection, personalized assessment, and clinical decision-making in psychosis-spectrum research.

We propose a new automated evaluation metric for machine-generated radiology reports using the successful COMET architecture adapted for the radiology domain. We train and publish four medically-oriented model checkpoints, including one trained on RadGraph, a radiology knowledge graph. Our results show that our metric correlates moderately to high with established metrics such as BERTscore, BLEU, and CheXbert scores. Furthermore, we demonstrate that one of our checkpoints exhibits a high correlation with human judgment, as assessed using the publicly available annotations of six board-certified radiologists, using a set of 200 reports. We also performed our own analysis gathering annotations with two radiologists on a collection of 100 reports. The results indicate the potential effectiveness of our method as a radiology-specific evaluation metric. The code, data, and model checkpoints to reproduce our findings will be publicly available.

Recent transformer-based models have made significant strides in generating radiology reports from chest X-ray images. However, a prominent challenge remains: these models often lack prior knowledge, resulting in the generation of synthetic reports that mistakenly reference non-existent prior exams. This discrepancy can be attributed to a knowledge gap between radiologists and the generation models. While radiologists possess patient-specific prior information, the models solely receive X-ray images at a specific time point. To tackle this issue, we propose a novel approach that leverages a rule-based labeler to extract comparison prior information from radiology reports. This extracted comparison prior is then seamlessly integrated into state-of-the-art transformer-based models, enabling them to produce more realistic and comprehensive reports. Our method is evaluated on English report datasets, such as IU X-ray and MIMIC-CXR. The results demonstrate that our approach surpasses baseline models in terms of natural language generation metrics. Notably, our model generates reports that are free from false references to non-existent prior exams, setting it apart from previous models. By addressing this limitation, our approach represents a significant step towards bridging the gap between radiologists and generation models in the domain of medical report generation.

Early detection of COVID-19 is an ongoing area of research that can help with triage, monitoring and general health assessment of potential patients and may reduce operational strain on hospitals that cope with the coronavirus pandemic. Different machine learning techniques have been used in the literature to detect coronavirus using routine clinical data (blood tests, and vital signs). Data breaches and information leakage when using these models can bring reputational damage and cause legal issues for hospitals. In spite of this, protecting healthcare models against leakage of potentially sensitive information is an understudied research area. In this work, we examine two machine learning approaches, intended to predict a patient's COVID-19 status using routinely collected and readily available clinical data. We employ adversarial training to explore robust deep learning architectures that protect attributes related to demographic information about the patients. The two models we examine in this work are intended to preserve sensitive information against adversarial attacks and information leakage. In a series of experiments using datasets from the Oxford University Hospitals, Bedfordshire Hospitals NHS Foundation Trust, University Hospitals Birmingham NHS Foundation Trust, and Portsmouth Hospitals University NHS Trust we train and test two neural networks that predict PCR test results using information from basic laboratory blood tests, and vital signs performed on a patients' arrival to hospital. We assess the level of privacy each one of the models can provide and show the efficacy and robustness of our proposed architectures against a comparable baseline. One of our main contributions is that we specifically target the development of effective COVID-19 detection models with built-in mechanisms in order to selectively protect sensitive attributes against adversarial attacks.