Modern orchards are planted in structured rows with distinct panel divisions to improve management. Accurate and efficient joint segmentation of point cloud from Panel to Tree and Branch (P2TB) is essential for robotic operations. However, most current segmentation methods focus on single instance segmentation and depend on a sequence of deep networks to perform joint tasks. This strategy hinders the use of hierarchical information embedded in the data, leading to both error accumulation and increased costs for annotation and computation, which limits its scalability for real-world applications. In this study, we proposed a novel approach that incorporated a Real2Sim L-TreeGen for training data generation and a joint model (J-P2TB) designed for the P2TB task. The J-P2TB model, trained on the generated simulation dataset, was used for joint segmentation of real-world panel point clouds via zero-shot learning. Compared to representative methods, our model outperformed them in most segmentation metrics while using 40% fewer learnable parameters. This Sim2Real result highlighted the efficacy of L-TreeGen in model training and the performance of J-P2TB for joint segmentation, demonstrating its strong accuracy, efficiency, and generalizability for real-world applications. These improvements would not only greatly benefit the development of robots for automated orchard operations but also advance digital twin technology.

Small-scale robots offer significant potential in minimally-invasive medical procedures. Due to the nature of soft biological tissues, however, robots are exposed to complex environments with various challenges in locomotion, which is essential to overcome for useful medical tasks. A single mini-robot often provides insufficient force on slippery biological surfaces to carry medical instruments, such as a fluid catheter or an electrical wire. Here, for the first time, we report a team of millirobots (TrainBot) that can generate around two times higher actuating force than a TrainBot unit by forming a convoy to collaboratively carry long and heavy cargos. The feet of each unit are optimized to increase the propulsive force around three times so that it can effectively crawl on slippery biological surfaces. A human-scale permanent magnetic set-up is developed to wirelessly actuate and control the TrainBot to transport heavy and lengthy loads through narrow biological lumens, such as the intestine and the bile duct. We demonstrate the first electrocauterization performed by the TrainBot to relieve a biliary obstruction and open a tunnel for fluid drainage and drug delivery. The developed technology sheds light on the collaborative strategy of small-scale robots for future minimally-invasive surgical procedures.

Magnetism is widely used for the wireless localization and actuation of robots and devices for medical procedures. However, current static magnetic localization methods suffer from large required magnets and are limited to only five degrees of freedom due to a fundamental constraint of the rotational symmetry around the magnetic axis. We present the small-scale magneto-oscillatory localization (SMOL) method, which is capable of wirelessly localizing a millimeter-scale tracker with full six degrees of freedom in deep biological tissues. The SMOL device uses the temporal oscillation of a mechanically resonant cantilever with a magnetic dipole to break the rotational symmetry, and exploits the frequency-response to achieve a high signal-to-noise ratio with sub-millimeter accuracy over a large distance of up to 12 centimeters and quasi-continuous refresh rates up to 200 Hz. Integration into real-time closed-loop controlled robots and minimally-invasive surgical tools are demonstrated to reveal the vast potential of the SMOL method.

Large language models (LLMs) have revolutionized Natural Language Processing (NLP) by minimizing the need for complex feature engineering. However, the application of LLMs in specialized domains like biopharmaceuticals and chemistry remains largely unexplored. These fields are characterized by intricate terminologies, specialized knowledge, and a high demand for precision areas where general purpose LLMs often fall short. In this study, we introduce PharmaGPT, a suite of domain specilized LLMs with 13 billion and 70 billion parameters, specifically trained on a comprehensive corpus tailored to the Bio-Pharmaceutical and Chemical domains. Our evaluation shows that PharmaGPT surpasses existing general models on specific-domain benchmarks such as NAPLEX, demonstrating its exceptional capability in domain-specific tasks. Remarkably, this performance is achieved with a model that has only a fraction, sometimes just one-tenth-of the parameters of general-purpose large models. This advancement establishes a new benchmark for LLMs in the bio-pharmaceutical and chemical fields, addressing the existing gap in specialized language modeling. It also suggests a promising path for enhanced research and development, paving the way for more precise and effective NLP applications in these areas.

In recent years, large language models(LLMs) have attracted significant attention due to their exceptional performance across a multitude of natural language process tasks, and have been widely applied in various fields. However, the application of large language models in the Intellectual Property (IP) domain is challenging due to the strong need for specialized knowledge, privacy protection, processing of extremely long text in this field. In this technical report, we present for the first time a low-cost, standardized procedure for training IP-oriented LLMs, meeting the unique requirements of the IP domain. Using this standard process, we have trained the PatentGPT series models based on open-source pretrained models. By evaluating them on the open-source IP-oriented benchmark MOZIP, our domain-specific LLMs outperforms GPT-4, indicating the effectiveness of the proposed training procedure and the expertise of the PatentGPT models in the IP domain. Remarkably, our model surpassed GPT-4 on the 2019 China Patent Agent Qualification Examination, scoring 65 and matching human expert levels. Additionally, the PatentGPT model, which utilizes the SMoE architecture, achieves performance comparable to that of GPT-4 in the IP domain and demonstrates a better cost-performance ratio on long-text tasks, potentially serving as an alternative to GPT-4 within the IP domain.

Robotic branch pruning is a significantly growing research area to cope with the shortage of labor force in the context of agriculture. One fundamental requirement in robotic pruning is the perception of detailed geometry and topology of branches. However, the point clouds obtained in agricultural settings often exhibit incompleteness due to several constraints, thereby restricting the accuracy of downstream robotic pruning. In this work, we addressed the issue of point cloud quality through a simulation-based deep neural network, leveraging a Real-to-Simulation (Real2Sim) data generation pipeline that not only eliminates the need for manual parameterization but also guarantees the realism of simulated data. The simulation-based neural network was applied to jointly perform point cloud completion and skeletonization on real-world partial branches, without additional real-world training. The Sim2Real qualitative completion and skeletonization results showed the model's remarkable capability for geometry reconstruction and topology prediction. Additionally, we quantitatively evaluated the Sim2Real performance by comparing branch-level trait characterization errors using raw incomplete data and complete data. The Mean Absolute Error (MAE) reduced by 75% and 8% for branch diameter and branch angle estimation, respectively, using the best complete data, which indicates the effectiveness of the Real2Sim data in a zero-shot generalization setting. The characterization improvements contributed to the precision and efficacy of robotic branch pruning.

Small-scale robots hold great potential for targeted cargo delivery in minimally-inv asive medicine. However, current robots often face challenges to locomote efficiently on slip pery biological tissue surfaces, especially when loaded with heavy cargos. Here, we report a magnetic millirobot that can walk on rough and slippery biological tissues by anchoring itself on the soft tissue surface alternatingly with two feet and reciprocally rotating the body to mov e forward. We experimentally studied the locomotion, validated it with numerical simulations and optimized the actuation parameters to fit various terrains and loading conditions. Further more, we developed a permanent magnet set-up to enable wireless actuation within a huma n-scale volume which allows precise control of the millirobot to follow complex trajectories, cl imb vertical walls, and carry cargo up to four times of its own weight. Upon reaching the targ et location, it performs a deployment sequence to release the liquid drug into tissues. The ro bust gait of our millirobot on rough biological terrains, combined with its heavy load capacity, make it a versatile and effective miniaturized vehicle for targeted cargo delivery.

Quantification of behavior is critical in applications ranging from neuroscience, veterinary medicine and animal conservation efforts. A common key step for behavioral analysis is first extracting relevant keypoints on animals, known as pose estimation. However, reliable inference of poses currently requires domain knowledge and manual labeling effort to build supervised models. We present a series of technical innovations that enable a new method, collectively called SuperAnimal, to develop unified foundation models that can be used on over 45 species, without additional human labels. Concretely, we introduce a method to unify the keypoint space across differently labeled datasets (via our generalized data converter) and for training these diverse datasets in a manner such that they don't catastrophically forget keypoints given the unbalanced inputs (via our keypoint gradient masking and memory replay approaches). These models show excellent performance across six pose benchmarks. Then, to ensure maximal usability for end-users, we demonstrate how to fine-tune the models on differently labeled data and provide tooling for unsupervised video adaptation to boost performance and decrease jitter across frames. If the models are fine-tuned, we show SuperAnimal models are 10-100$\times$ more data efficient than prior transfer-learning-based approaches. We illustrate the utility of our models in behavioral classification in mice and gait analysis in horses. Collectively, this presents a data-efficient solution for animal pose estimation.

The deep learning approach to detecting malicious software (malware) is promising but has yet to tackle the problem of dataset shift, namely that the joint distribution of examples and their labels associated with the test set is different from that of the training set. This problem causes the degradation of deep learning models without users' notice. In order to alleviate the problem, one approach is to let a classifier not only predict the label on a given example but also present its uncertainty (or confidence) on the predicted label, whereby a defender can decide whether to use the predicted label or not. While intuitive and clearly important, the capabilities and limitations of this approach have not been well understood. In this paper, we conduct an empirical study to evaluate the quality of predictive uncertainties of malware detectors. Specifically, we re-design and build 24 Android malware detectors (by transforming four off-the-shelf detectors with six calibration methods) and quantify their uncertainties with nine metrics, including three metrics dealing with data imbalance. Our main findings are: (i) predictive uncertainty indeed helps achieve reliable malware detection in the presence of dataset shift, but cannot cope with adversarial evasion attacks; (ii) approximate Bayesian methods are promising to calibrate and generalize malware detectors to deal with dataset shift, but cannot cope with adversarial evasion attacks; (iii) adversarial evasion attacks can render calibration methods useless, and it is an open problem to quantify the uncertainty associated with the predicted labels of adversarial examples (i.e., it is not effective to use predictive uncertainty to detect adversarial examples).

Pre-sales customer service is of importance to E-commerce platforms as it contributes to optimizing customers' buying process. To better serve users, we propose AliMe KG, a domain knowledge graph in E-commerce that captures user problems, points of interests (POI), item information and relations thereof. It helps to understand user needs, answer pre-sales questions and generate explanation texts. We applied AliMe KG to several online business scenarios such as shopping guide, question answering over properties and recommendation reason generation, and gained positive results. In the paper, we systematically introduce how we construct domain knowledge graph from free text, and demonstrate its business value with several applications. Our experience shows that mining structured knowledge from free text in vertical domain is practicable, and can be of substantial value in industrial settings.