The usage of medical image data for the training of large-scale machine learning approaches is particularly challenging due to its scarce availability and the costly generation of data annotations, typically requiring the engagement of medical professionals. The rapid development of generative models allows towards tackling this problem by leveraging large amounts of realistic synthetically generated data for the training process. However, randomly choosing synthetic samples, might not be an optimal strategy. In this work, we investigate the targeted generation of synthetic training data, in order to improve the accuracy and robustness of image classification. Therefore, our approach aims to guide the generative model to synthesize data with high epistemic uncertainty, since large measures of epistemic uncertainty indicate underrepresented data points in the training set. During the image generation we feed images reconstructed by an auto encoder into the classifier and compute the mutual information over the class-probability distribution as a measure for uncertainty.We alter the feature space of the autoencoder through an optimization process with the objective of maximizing the classifier uncertainty on the decoded image. By training on such data we improve the performance and robustness against test time data augmentations and adversarial attacks on several classifications tasks.

When models, e.g., for semantic segmentation, are applied to images that are vastly different from training data, the performance will drop significantly. Domain adaptation methods try to overcome this issue, but need samples from the target domain. However, this might not always be feasible for various reasons and therefore domain generalization methods are useful as they do not require any target data. We present a new diffusion-based domain extension (DIDEX) method and employ a diffusion model to generate a pseudo-target domain with diverse text prompts. In contrast to existing methods, this allows to control the style and content of the generated images and to introduce a high diversity. In a second step, we train a generalizing model by adapting towards this pseudo-target domain. We outperform previous approaches by a large margin across various datasets and architectures without using any real data. For the generalization from GTA5, we improve state-of-the-art mIoU performance by 3.8% absolute on average and for SYNTHIA by 11.8% absolute, marking a big step for the generalization performance on these benchmarks. Code is available at https://github.com/JNiemeijer/DIDEX

Deep neural networks (DNNs) have proven their capabilities in many areas in the past years, such as robotics, or automated driving, enabling technological breakthroughs. DNNs play a significant role in environment perception for the challenging application of automated driving and are employed for tasks such as detection, semantic segmentation, and sensor fusion. Despite this progress and tremendous research efforts, several issues still need to be addressed that limit the applicability of DNNs in automated driving. The bad generalization of DNNs to new, unseen domains is a major problem on the way to a safe, large-scale application, because manual annotation of new domains is costly, particularly for semantic segmentation. For this reason, methods are required to adapt DNNs to new domains without labeling effort. The task, which these methods aim to solve is termed unsupervised domain adaptation (UDA). While several different domain shifts can challenge DNNs, the shift between synthetic and real data is of particular importance for automated driving, as it allows the use of simulation environments for DNN training. In this work, we present an overview of the current state of the art in this field of research. We categorize and explain the different approaches for UDA. The number of considered publications is larger than any other survey on this topic. The scope of this survey goes far beyond the description of the UDA state-of-the-art. Based on our large data and knowledge base, we present a quantitative comparison of the approaches and use the observations to point out the latest trends in this field. In the following, we conduct a critical analysis of the state-of-the-art and highlight promising future research directions. With this survey, we aim to facilitate UDA research further and encourage scientists to exploit novel research directions to generalize DNNs better.