Capturing subtle speech disruptions across the psychosis spectrum is challenging because of the inherent variability in speech patterns. This variability reflects individual differences and the fluctuating nature of symptoms in both clinical and non-clinical populations. Accounting for uncertainty in speech data is essential for predicting symptom severity and improving diagnostic precision. Speech disruptions characteristic of psychosis appear across the spectrum, including in non-clinical individuals. We develop an uncertainty-aware model integrating acoustic and linguistic features to predict symptom severity and psychosis-related traits. Quantifying uncertainty in specific modalities allows the model to address speech variability, improving prediction accuracy. We analyzed speech data from 114 participants, including 32 individuals with early psychosis and 82 with low or high schizotypy, collected through structured interviews, semi-structured autobiographical tasks, and narrative-driven interactions in German. The model improved prediction accuracy, reducing RMSE and achieving an F1-score of 83% with ECE = 4.5e-2, showing robust performance across different interaction contexts. Uncertainty estimation improved model interpretability by identifying reliability differences in speech markers such as pitch variability, fluency disruptions, and spectral instability. The model dynamically adjusted to task structures, weighting acoustic features more in structured settings and linguistic features in unstructured contexts. This approach strengthens early detection, personalized assessment, and clinical decision-making in psychosis-spectrum research.

Alzheimer's Disease (AD) is a significant and growing public health concern. Investigating alterations in speech and language patterns offers a promising path towards cost-effective and non-invasive early detection of AD on a large scale. Large language models (LLMs), such as GPT, have enabled powerful new possibilities for semantic text analysis. In this study, we leverage GPT-4 to extract five semantic features from transcripts of spontaneous patient speech. The features capture known symptoms of AD, but they are difficult to quantify effectively using traditional methods of computational linguistics. We demonstrate the clinical significance of these features and further validate one of them ("Word-Finding Difficulties") against a proxy measure and human raters. When combined with established linguistic features and a Random Forest classifier, the GPT-derived features significantly improve the detection of AD. Our approach proves effective for both manually transcribed and automatically generated transcripts, representing a novel and impactful use of recent advancements in LLMs for AD speech analysis.

Eye movements can reveal valuable insights into various aspects of human mental processes, physical well-being, and actions. Recently, several datasets have been made available that simultaneously record EEG activity and eye movements. This has triggered the development of various methods to predict gaze direction based on brain activity. However, most of these methods lack interpretability, which limits their technology acceptance. In this paper, we leverage a large data set of simultaneously measured Electroencephalography (EEG) and Eye tracking, proposing an interpretable model for gaze estimation from EEG data. More specifically, we present a novel attention-based deep learning framework for EEG signal analysis, which allows the network to focus on the most relevant information in the signal and discard problematic channels. Additionally, we provide a comprehensive evaluation of the presented framework, demonstrating its superiority over current methods in terms of accuracy and robustness. Finally, the study presents visualizations that explain the results of the analysis and highlights the potential of attention mechanism for improving the efficiency and effectiveness of EEG data analysis in a variety of applications.

In this study, we validate the findings of previously published papers, showing the feasibility of an Electroencephalography (EEG) based gaze estimation. Moreover, we extend previous research by demonstrating that with only a slight drop in model performance, we can significantly reduce the number of electrodes, indicating that a high-density, expensive EEG cap is not necessary for the purposes of EEG-based eye tracking. Using data-driven approaches, we establish which electrode clusters impact gaze estimation and how the different types of EEG data preprocessing affect the models' performance. Finally, we also inspect which recorded frequencies are most important for the defined tasks.