Histopathology and transcriptomics are fundamental modalities in oncology, encapsulating the morphological and molecular aspects of the disease. Multi-modal self-supervised learning has demonstrated remarkable potential in learning pathological representations by integrating diverse data sources. Conventional multi-modal integration methods primarily emphasize modality alignment, while paying insufficient attention to retaining the modality-specific structures. However, unlike conventional scenarios where multi-modal inputs share highly overlapping features, histopathology and transcriptomics exhibit pronounced heterogeneity, offering orthogonal yet complementary insights. Histopathology provides morphological and spatial context, elucidating tissue architecture and cellular topology, whereas transcriptomics delineates molecular signatures through gene expression patterns. This inherent disparity introduces a major challenge in aligning them while maintaining modality-specific fidelity. To address these challenges, we present MIRROR, a novel multi-modal representation learning method designed to foster both modality alignment and retention. MIRROR employs dedicated encoders to extract comprehensive features for each modality, which is further complemented by a modality alignment module to achieve seamless integration between phenotype patterns and molecular profiles. Furthermore, a modality retention module safeguards unique attributes from each modality, while a style clustering module mitigates redundancy and enhances disease-relevant information by modeling and aligning consistent pathological signatures within a clustering space. Extensive evaluations on TCGA cohorts for cancer subtyping and survival analysis highlight MIRROR's superior performance, demonstrating its effectiveness in constructing comprehensive oncological feature representations and benefiting the cancer diagnosis.

Large Language Models (LLMs) have become an indispensable part of natural language processing tasks. However, autoregressive sampling has become an efficiency bottleneck. Multi-Draft Speculative Decoding (MDSD) is a recent approach where, when generating each token, a small draft model generates multiple drafts, and the target LLM verifies them in parallel, ensuring that the final output conforms to the target model distribution. The two main design choices in MDSD are the draft sampling method and the verification algorithm. For a fixed draft sampling method, the optimal acceptance rate is a solution to an optimal transport problem, but the complexity of this problem makes it difficult to solve for the optimal acceptance rate and measure the gap between existing verification algorithms and the theoretical upper bound. This paper discusses the dual of the optimal transport problem, providing a way to efficiently compute the optimal acceptance rate. For the first time, we measure the theoretical upper bound of MDSD efficiency for vocabulary sizes in the thousands and quantify the gap between existing verification algorithms and this bound. We also compare different draft sampling methods based on their optimal acceptance rates. Our results show that the draft sampling method strongly influences the optimal acceptance rate, with sampling without replacement outperforming sampling with replacement. Additionally, existing verification algorithms do not reach the theoretical upper bound for both without replacement and with replacement sampling. Our findings suggest that carefully designed draft sampling methods can potentially improve the optimal acceptance rate and enable the development of verification algorithms that closely match the theoretical upper bound.

The emergence of Large Language Models (LLMs) has advanced the multilingual machine translation (MMT), yet the Curse of Multilinguality (CoM) remains a major challenge. Existing work in LLM-based MMT typically mitigates this issue via scaling up training and computation budget, which raises a critical question: Is scaling up the training and computation budget truly necessary for high-quality MMT, or can a deeper understanding of CoM provide a more efficient solution? To explore this problem, we analyze the linguistic conflicts and synergy, the underlying mechanism of CoM during post-training phase. We identify an asymmetric phenomenon in linguistic conflicts and synergy: the dominance of conflicts and synergy varies in different translation directions, leading to sub-optimal adaptation in existing post-training methods. We further find that a significant bottleneck in MMT appears to lie in post-training rather than multilingual pre-training, suggesting the need for more effective adaptation strategies. Building on these new insights, we propose a direction-aware training approach, combined with group-wise model merging, to address asymmetry in linguistic conflicts and synergy explicitly. Leveraging this strategy, our method fine-tunes X-ALMA-13B-Pretrain-trained only with multilingual pre-training-achieving comparable performance to XALMA-13B (only SFT) while using only 20B pretraining tokens and 17B parameters-5.5x fewer pretraining-tokens and 1.7x fewer model size-with just 0.85 COMET drop on Flores-200 testsets of 50 languages.

As artificial intelligence surpasses human capabilities in text generation, the necessity to authenticate the origins of AI-generated content has become paramount. Unbiased watermarks offer a powerful solution by embedding statistical signals into language model-generated text without distorting the quality. In this paper, we introduce MCmark, a family of unbiased, Multi-Channel-based watermarks. MCmark works by partitioning the model's vocabulary into segments and promoting token probabilities within a selected segment based on a watermark key. We demonstrate that MCmark not only preserves the original distribution of the language model but also offers significant improvements in detectability and robustness over existing unbiased watermarks. Our experiments with widely-used language models demonstrate an improvement in detectability of over 10% using MCmark, compared to existing state-of-the-art unbiased watermarks. This advancement underscores MCmark's potential in enhancing the practical application of watermarking in AI-generated texts.

Large language models (LLMs) are increasingly integrated into real-world applications through retrieval-augmented generation (RAG) mechanisms to supplement their responses with up-to-date and domain-specific knowledge. However, the valuable and often proprietary nature of the knowledge bases used in RAG introduces the risk of unauthorized usage by adversaries. Existing methods that can be generalized as watermarking techniques to protect these knowledge bases typically involve poisoning attacks. However, these methods require to alter the results of verification samples (\eg, generating incorrect outputs), inevitably making them susceptible to anomaly detection and even introduce new security risks. To address these challenges, we propose \name{} for `harmless' copyright protection of knowledge bases. Instead of manipulating LLM's final output, \name{} implants distinct verification behaviors in the space of chain-of-thought (CoT) reasoning, maintaining the correctness of the final answer. Our method has three main stages: (1) \textbf{Generating CoTs}: For each verification question, we generate two CoTs, including a target CoT for building watermark behaviors; (2) \textbf{Optimizing Watermark Phrases and Target CoTs}: We optimize them to minimize retrieval errors under the black-box setting of suspicious LLM, ensuring that the watermarked verification queries activate the target CoTs without being activated in non-watermarked ones; (3) \textbf{Ownership Verification}: We exploit a pairwise Wilcoxon test to statistically verify whether a suspicious LLM is augmented with the protected knowledge base by comparing its responses to watermarked and benign verification queries. Our experiments on diverse benchmarks demonstrate that \name{} effectively protects knowledge bases against unauthorized usage while preserving the integrity and performance of the RAG.

Fine-tuning pre-trained Large Language Models (LLMs) for downstream tasks using First-Order (FO) optimizers presents significant computational challenges. Parameter-Efficient Fine-Tuning(PEFT) methods have been proposed to address these challenges by freezing most model parameters and training only a small subset. While PEFT is efficient, it may not outperform full fine-tuning when high task-specific performance is required. Zeroth-Order (ZO) methods offer an alternative for fine-tuning the entire pre-trained model by approximating gradients using only the forward pass, thus eliminating the computational burden of back-propagation in first-order methods. However, when implementing ZO methods, a hard prompt is crucial, and relying on simple, fixed hard prompts may not be optimal. In this paper, we propose a bilevel optimization framework that complements ZO methods with PEFT to mitigate sensitivity to hard prompts while efficiently and effectively fine-tuning LLMs. Our Bilevel ZOFO (Zeroth-Order-First-Order) method employs a double-loop optimization strategy, where only the gradient of the PEFT model and the forward pass of the base model are required. We provide convergence guarantees for Bilevel ZOFO. Empirically, we demonstrate that Bilevel ZOFO outperforms both PEFT and ZO methods in single-task settings while maintaining similar memory efficiency. Additionally, we show its strong potential for multitask learning. Compared to current first-order meta-training algorithms for multitask learning, our method has significantly lower computational demands while maintaining or improving performance.

Federated Learning (FL) is a distributed learning paradigm where clients collaboratively train a model while keeping their own data private. With an increasing scale of clients and models, FL encounters two key challenges, client drift due to a high degree of statistical/system heterogeneity, and lack of adaptivity. However, most existing FL research is based on unrealistic assumptions that virtually ignore system heterogeneity. In this paper, we propose Client-Centric Federated Adaptive Optimization, which is a class of novel federated adaptive optimization approaches. We enable several features in this framework such as arbitrary client participation, asynchronous server aggregation, and heterogeneous local computing, which are ubiquitous in real-world FL systems but are missed in most existing works. We provide a rigorous convergence analysis of our proposed framework for general nonconvex objectives, which is shown to converge with the best-known rate. Extensive experiments show that our approaches consistently outperform the baseline by a large margin across benchmarks.

Recent advancements in large vision language models (VLMs) tailored for autonomous driving (AD) have shown strong scene understanding and reasoning capabilities, making them undeniable candidates for end-to-end driving systems. However, limited work exists on studying the trustworthiness of DriveVLMs -- a critical factor that directly impacts public transportation safety. In this paper, we introduce AutoTrust, a comprehensive trustworthiness benchmark for large vision-language models in autonomous driving (DriveVLMs), considering diverse perspectives -- including trustfulness, safety, robustness, privacy, and fairness. We constructed the largest visual question-answering dataset for investigating trustworthiness issues in driving scenarios, comprising over 10k unique scenes and 18k queries. We evaluated six publicly available VLMs, spanning from generalist to specialist, from open-source to commercial models. Our exhaustive evaluations have unveiled previously undiscovered vulnerabilities of DriveVLMs to trustworthiness threats. Specifically, we found that the general VLMs like LLaVA-v1.6 and GPT-4o-mini surprisingly outperform specialized models fine-tuned for driving in terms of overall trustworthiness. DriveVLMs like DriveLM-Agent are particularly vulnerable to disclosing sensitive information. Additionally, both generalist and specialist VLMs remain susceptible to adversarial attacks and struggle to ensure unbiased decision-making across diverse environments and populations. Our findings call for immediate and decisive action to address the trustworthiness of DriveVLMs -- an issue of critical importance to public safety and the welfare of all citizens relying on autonomous transportation systems. Our benchmark is publicly available at \url{https://github.com/taco-group/AutoTrust}, and the leaderboard is released at \url{https://taco-group.github.io/AutoTrust/}.

Recent advances in diffusion generative models have yielded remarkable progress. While the quality of generated content continues to improve, these models have grown considerably in size and complexity. This increasing computational burden poses significant challenges, particularly in resource-constrained deployment scenarios such as mobile devices. The combination of model pruning and knowledge distillation has emerged as a promising solution to reduce computational demands while preserving generation quality. However, this technique inadvertently propagates undesirable behaviors, including the generation of copyrighted content and unsafe concepts, even when such instances are absent from the fine-tuning dataset. In this paper, we propose a novel bilevel optimization framework for pruned diffusion models that consolidates the fine-tuning and unlearning processes into a unified phase. Our approach maintains the principal advantages of distillation-namely, efficient convergence and style transfer capabilities-while selectively suppressing the generation of unwanted content. This plug-in framework is compatible with various pruning and concept unlearning methods, facilitating efficient, safe deployment of diffusion models in controlled environments.

Bilevel Optimization has experienced significant advancements recently with the introduction of new efficient algorithms. Mirroring the success in single-level optimization, stochastic gradient-based algorithms are widely used in bilevel optimization. However, a common limitation in these algorithms is the presumption of independent sampling, which can lead to increased computational costs due to the complicated hyper-gradient formulation of bilevel problems. To address this challenge, we study the example-selection strategy for bilevel optimization in this work. More specifically, we introduce a without-replacement sampling based algorithm which achieves a faster convergence rate compared to its counterparts that rely on independent sampling. Beyond the standard bilevel optimization formulation, we extend our discussion to conditional bilevel optimization and also two special cases: minimax and compositional optimization.