Melody preservation is crucial in singing voice conversion (SVC). However, in many scenarios, audio is often accompanied with background music (BGM), which can cause audio distortion and interfere with the extraction of melody and other key features, significantly degrading SVC performance. Previous methods have attempted to address this by using more robust neural network-based melody extractors, but their performance drops sharply in the presence of complex accompaniment. Other approaches involve performing source separation before conversion, but this often introduces noticeable artifacts, leading to a significant drop in conversion quality and increasing the user's operational costs. To address these issues, we introduce a novel SVC method that uses self-supervised representation-based melody features to improve melody modeling accuracy in the presence of BGM. In our experiments, we compare the effectiveness of different self-supervised learning (SSL) models for melody extraction and explore for the first time how SSL benefits the task of melody extraction. The experimental results demonstrate that our proposed SVC model significantly outperforms existing baseline methods in terms of melody accuracy and shows higher similarity and naturalness in both subjective and objective evaluations across noisy and clean audio environments.

We introduce AnyEnhance, a unified generative model for voice enhancement that processes both speech and singing voices. Based on a masked generative model, AnyEnhance is capable of handling both speech and singing voices, supporting a wide range of enhancement tasks including denoising, dereverberation, declipping, super-resolution, and target speaker extraction, all simultaneously and without fine-tuning. AnyEnhance introduces a prompt-guidance mechanism for in-context learning, which allows the model to natively accept a reference speaker's timbre. In this way, it could boost enhancement performance when a reference audio is available and enable the target speaker extraction task without altering the underlying architecture. Moreover, we also introduce a self-critic mechanism into the generative process for masked generative models, yielding higher-quality outputs through iterative self-assessment and refinement. Extensive experiments on various enhancement tasks demonstrate AnyEnhance outperforms existing methods in terms of both objective metrics and subjective listening tests. Demo audios are publicly available at https://amphionspace.github.io/anyenhance/.

Variational Autoencoders (VAEs) constitute a crucial component of neural symbolic music generation, among which some works have yielded outstanding results and attracted considerable attention. Nevertheless, previous VAEs still encounter issues with overly long feature sequences and generated results lack contextual coherence, thus the challenge of modeling long multi-track symbolic music still remains unaddressed. To this end, we propose Multi-view MidiVAE, as one of the pioneers in VAE methods that effectively model and generate long multi-track symbolic music. The Multi-view MidiVAE utilizes the two-dimensional (2-D) representation, OctupleMIDI, to capture relationships among notes while reducing the feature sequences length. Moreover, we focus on instrumental characteristics and harmony as well as global and local information about the musical composition by employing a hybrid variational encoding-decoding strategy to integrate both Track- and Bar-view MidiVAE features. Objective and subjective experimental results on the CocoChorales dataset demonstrate that, compared to the baseline, Multi-view MidiVAE exhibits significant improvements in terms of modeling long multi-track symbolic music.

Batch effects (BEs) refer to systematic technical differences in data collection unrelated to biological variations whose noise is shown to negatively impact machine learning (ML) model generalizability. Here we release CohortFinder, an open-source tool aimed at mitigating BEs via data-driven cohort partitioning. We demonstrate CohortFinder improves ML model performance in downstream medical image processing tasks. CohortFinder is freely available for download at cohortfinder.com.

The discovery of patterns associated with diagnosis, prognosis, and therapy response in digital pathology images often requires intractable labeling of large quantities of histological objects. Here we release an open-source labeling tool, PatchSorter, which integrates deep learning with an intuitive web interface. Using >100,000 objects, we demonstrate a >7x improvement in labels per second over unaided labeling, with minimal impact on labeling accuracy, thus enabling high-throughput labeling of large datasets. While current hardware and machine learning algorithms can locate and type objects at scale, the manual assignment and review of large labeled datasets used to train or validate models remains arduous. For example, a single WSI may contain over 1 million cells, which, if requiring a modest 1 second per cell to label, would result in approximately 12 non-stop days of effort. To aid experts (e.g., pathologists) in this labeling process, several image analysis algorithms have been proposed PS is a user-friendly, browser-based tool, which allows the user to leverage deep learning (DL) to quickly review and apply labels at a group, as opposed to a single object, level (Figure 1).