Repositioning drug-disease relationships has always been a hot field of research. However, actual cases of biologically validated drug relocation remain very limited, and existing models have not yet fully utilized the structural information of the drug. Furthermore, most repositioning models are only used to complete the relationship matrix, and their practicality is poor when dealing with drug cold start problems. This paper proposes a structure-enhanced multimodal relationship prediction model (SMRP). SMPR is based on the SMILE structure of the drug, using the Mol2VEC method to generate drug embedded representations, and learn disease embedded representations through heterogeneous network graph neural networks. Ultimately, a drug-disease relationship matrix is constructed. In addition, to reduce the difficulty of users' use, SMPR also provides a cold start interface based on structural similarity based on reposition results to simply and quickly predict drug-related diseases. The repositioning ability and cold start capability of the model are verified from multiple perspectives. While the AUC and ACUPR scores of repositioning reach 99% and 61% respectively, the AUC of cold start achieve 80%. In particular, the cold start Recall indicator can reach more than 70%, which means that SMPR is more sensitive to positive samples. Finally, case analysis is used to verify the practical value of the model and visual analysis directly demonstrates the improvement of the structure to the model. For quick use, we also provide local deployment of the model and package it into an executable program.

The advanced processing and reasoning capabilities of multimodal large language models (MLLMs) have driven substantial progress in vision-language (VL) understanding tasks. However, while effective for tasks governed by straightforward logic, MLLMs often encounter challenges when reasoning over complex, interdependent logic structures. To address this limitation, we introduce \textit{AgentPS}, a novel framework that integrates Agentic Process Supervision into MLLMs via multi-round question answering during fine-tuning. \textit{AgentPS} demonstrates significant performance improvements over baseline MLLMs on proprietary TikTok datasets, due to its integration of process supervision and structured sequential reasoning. Furthermore, we show that replacing human-annotated labels with LLM-generated labels retains much of the performance gain, highlighting the framework's practical scalability in industrial applications. These results position \textit{AgentPS} as a highly effective and efficient architecture for multimodal classification tasks. Its adaptability and scalability, especially when enhanced by automated annotation generation, make it a powerful tool for handling large-scale, real-world challenges.

Recently, with the emergence of recent Multimodal Large Language Model (MLLM) technology, it has become possible to exploit its video understanding capability on different classification tasks. In practice, we face the difficulty of huge requirements for GPU resource if we need to deploy MLLMs online. In this paper, we propose COEF-VQ, a novel cascaded MLLM framework for better video quality understanding on TikTok. To this end, we first propose a MLLM fusing all visual, textual and audio signals, and then develop a cascade framework with a lightweight model as pre-filtering stage and MLLM as fine-consideration stage, significantly reducing the need for GPU resource, while retaining the performance demonstrated solely by MLLM. To demonstrate the effectiveness of COEF-VQ, we deployed this new framework onto the video management platform (VMP) at TikTok, and performed a series of detailed experiments on two in-house tasks related to video quality understanding. We show that COEF-VQ leads to substantial performance gains with limit resource consumption in these two tasks.

We propose Hymba, a family of small language models featuring a hybrid-head parallel architecture that integrates transformer attention mechanisms with state space models (SSMs) for enhanced efficiency. Attention heads provide high-resolution recall, while SSM heads enable efficient context summarization. Additionally, we introduce learnable meta tokens that are prepended to prompts, storing critical information and alleviating the "forced-to-attend" burden associated with attention mechanisms. This model is further optimized by incorporating cross-layer key-value (KV) sharing and partial sliding window attention, resulting in a compact cache size. During development, we conducted a controlled study comparing various architectures under identical settings and observed significant advantages of our proposed architecture. Notably, Hymba achieves state-of-the-art results for small LMs: Our Hymba-1.5B-Base model surpasses all sub-2B public models in performance and even outperforms Llama-3.2-3B with 1.32% higher average accuracy, an 11.67x cache size reduction, and 3.49x throughput.

Dielectric elastomer actuators (DEAs), also recognized as artificial muscle, have been widely developed for the soft locomotion robot. With the complaint skeleton and miniaturized dimension, they are well suited for the narrow space inspection. In this work, we propose a novel low profile (1.1mm) and lightweight (1.8g) bi-stable in-plane DEA (Bi-DEA) constructed by supporting a dielectric elastomer onto a flat bi-stable mechanism. It has an amplified displacement and output force compared with the in-plane DEA (I-DEA) without the bi-stable mechanism. Then, the Bi-DEA is applied to a thin soft robot, using three electrostatic adhesive pads (EA-Pads) as anchoring elements. This robot is capable of crawling and climbing to access millimetre-scale narrow gaps. A theoretical model of the bi-stable mechanism and the DEA are presented. The enhanced performance of the Bi-DEA induced by the mechanism is experimentally validated. EA-Pad provides the adhesion between the actuator and the locomotion substrate, allowing crawling and climbing on various surfaces, i.e., paper and acrylic. The thin soft robot has been demonstrated to be capable of crawling through a 4mm narrow gap with a speed up to 3.3mm/s (0.07 body length per second and 2.78 body thickness per second).

Soft parallel robots with their manipulation safety and low commercial cost show a promising future for delicate operations and safe human-robot interactions. However, promoting the use of electroactive polymers (EAPs) is still challenging due to the under-improving quality of the product and the dynamic modelling of the collaborations between multiple actuators. This article presents the design, fabrication, modelling and control of a parallel kinematics Delta robot actuated by dielectric elastomer actuators (DEAs). The trade-off between the actuation force and stroke is retaken by an angular stroke amplification mechanism, and the weight of the robot frame is reduced by utilizing 3D puzzling strip structures. A generic way of constructing a high-stability conductive paint on a silicon-based film has been achieved by laser scanning the DE-film and then sandwiching a conductive particle-based electrode with a paint which is mixed by the particles and photosensitive resin. Compared to the wildly used carbon grease, the fabricated electrode shows a higher consistency in its dynamic behaviour before and after the on-stand test. Finally, to predict the output force and inverse motion of the robot end effector, we constructed the inverse dynamic model by introducing an expanded Bergstrom-Boyce model to the constitutive behavior of the dielectric film. The experimental results show a prediction of robot output force with RSME of 12.4% when the end effector remains stationary, and a well-followed trajectory with less than RSME 2.5%.

Traditional Chinese medicine (TCM) relies on specific combinations of herbs in prescriptions to treat symptoms and signs, a practice that spans thousands of years. Predicting TCM prescriptions presents a fascinating technical challenge with practical implications. However, this task faces limitations due to the scarcity of high-quality clinical datasets and the intricate relationship between symptoms and herbs. To address these issues, we introduce DigestDS, a new dataset containing practical medical records from experienced experts in digestive system diseases. We also propose a method, TCM-FTP (TCM Fine-Tuning Pre-trained), to leverage pre-trained large language models (LLMs) through supervised fine-tuning on DigestDS. Additionally, we enhance computational efficiency using a low-rank adaptation technique. TCM-FTP also incorporates data augmentation by permuting herbs within prescriptions, capitalizing on their order-agnostic properties. Impressively, TCM-FTP achieves an F1-score of 0.8031, surpassing previous methods significantly. Furthermore, it demonstrates remarkable accuracy in dosage prediction, achieving a normalized mean square error of 0.0604. In contrast, LLMs without fine-tuning perform poorly. Although LLMs have shown capabilities on a wide range of tasks, this work illustrates the importance of fine-tuning for TCM prescription prediction, and we have proposed an effective way to do that.

Large Language Models (LLMs) have demonstrated impressive in-context learning (ICL) capabilities from few-shot demonstration exemplars. While recent learning-based demonstration selection methods have proven beneficial to ICL by choosing more useful exemplars, their underlying mechanisms are opaque, hindering efforts to address limitations such as high training costs and poor generalization across tasks. These methods generally assume the selection process captures similarities between the exemplar and the target instance, however, it remains unknown what kinds of similarities are captured and vital to performing ICL. To dive into this question, we analyze the working mechanisms of the learning-based demonstration selection methods and empirically identify two important factors related to similarity measurement: 1) The ability to integrate different levels of task-agnostic text similarities between the input of exemplars and test cases enhances generalization power across different tasks. 2) Incorporating task-specific labels when measuring the similarities significantly improves the performance on each specific task. We validate these two findings through extensive quantitative and qualitative analyses across ten datasets and various LLMs. Based on our findings, we introduce two effective yet simplified exemplar selection methods catering to task-agnostic and task-specific demands, eliminating the costly LLM inference overhead.

Unlike squared (or alike) quadrotors, elongated bi-copters leverage natural superiority in crossing tight spaces. To date, extensive works have focused on the design, modeling, and control of bi-copters. Besides, a proper motion planner utilizing bi-copters' shape characteristics is essential to efficiently and safely traverse tight spaces, yet it has rarely been studied. Current motion planning methods will significantly compromise their ability to traverse narrow spaces if the map is inflated based on the long dimension of the bi-copter. In this paper, we propose an efficient motion planning method that enables the safe navigation of bi-copters through narrow spaces. We first adapt a dynamic, feasible path-finding algorithm with whole-body collision checks to generate a collision-free path. Subsequently, we jointly optimize the position and rotation of the bi-copter to produce a trajectory that is safe, dynamically feasible, and smooth. Extensive simulations and real-world experiments have been conducted to verify the reliability and robustness of the proposed method.

Synthetic image data generation represents a promising avenue for training deep learning models, particularly in the realm of transfer learning, where obtaining real images within a specific domain can be prohibitively expensive due to privacy and intellectual property considerations. This work delves into the generation and utilization of synthetic images derived from text-to-image generative models in facilitating transfer learning paradigms. Despite the high visual fidelity of the generated images, we observe that their naive incorporation into existing real-image datasets does not consistently enhance model performance due to the inherent distribution gap between synthetic and real images. To address this issue, we introduce a novel two-stage framework called bridged transfer, which initially employs synthetic images for fine-tuning a pre-trained model to improve its transferability and subsequently uses real data for rapid adaptation. Alongside, We propose dataset style inversion strategy to improve the stylistic alignment between synthetic and real images. Our proposed methods are evaluated across 10 different datasets and 5 distinct models, demonstrating consistent improvements, with up to 30% accuracy increase on classification tasks. Intriguingly, we note that the enhancements were not yet saturated, indicating that the benefits may further increase with an expanded volume of synthetic data. Pre-training a model on a large-scale dataset and subsequently transferring it to downstream tasks has proven to be both a practical and effective approach to achieving exceptional performance across a variety of tasks (Sharif Razavian et al., 2014; Donahue et al., 2014). In the transfer learning pipeline, a model is initially trained on a source dataset and later fine-tuned on various downstream datasets (aka target datasets). Source datasets are typically large-scale, general-purpose, and publicly available, such as ImageNet-1K/21K (Deng et al., 2009).