Recent advances in clinical AI have enabled remarkable progress across many clinical domains. However, existing benchmarks and models are primarily limited to a small set of modalities and tasks, which hinders the development of large-scale multimodal methods that can make holistic assessments of patient health and well-being. To bridge this gap, we introduce Clinical Large-Scale Integrative Multimodal Benchmark (CLIMB), a comprehensive clinical benchmark unifying diverse clinical data across imaging, language, temporal, and graph modalities. CLIMB comprises 4.51 million patient samples totaling 19.01 terabytes distributed across 2D imaging, 3D video, time series, graphs, and multimodal data. Through extensive empirical evaluation, we demonstrate that multitask pretraining significantly improves performance on understudied domains, achieving up to 29% improvement in ultrasound and 23% in ECG analysis over single-task learning. Pretraining on CLIMB also effectively improves models' generalization capability to new tasks, and strong unimodal encoder performance translates well to multimodal performance when paired with task-appropriate fusion strategies. Our findings provide a foundation for new architecture designs and pretraining strategies to advance clinical AI research. Code is released at https://github.com/DDVD233/climb.

While abundant research has been conducted on improving high-level visual understanding and reasoning capabilities of large multimodal models~(LMMs), their visual quality assessment~(IQA) ability has been relatively under-explored. Here we take initial steps towards this goal by employing the two-alternative forced choice~(2AFC) prompting, as 2AFC is widely regarded as the most reliable way of collecting human opinions of visual quality. Subsequently, the global quality score of each image estimated by a particular LMM can be efficiently aggregated using the maximum a posterior estimation. Meanwhile, we introduce three evaluation criteria: consistency, accuracy, and correlation, to provide comprehensive quantifications and deeper insights into the IQA capability of five LMMs. Extensive experiments show that existing LMMs exhibit remarkable IQA ability on coarse-grained quality comparison, but there is room for improvement on fine-grained quality discrimination. The proposed dataset sheds light on the future development of IQA models based on LMMs. The codes will be made publicly available at https://github.com/h4nwei/2AFC-LMMs.

Hierarchical Task Network (HTN) planning is showing its power in real-world planning. Although domain experts have partial hierarchical domain knowledge, it is time-consuming to specify all HTN methods, leaving them incomplete. On the other hand, traditional HTN learning approaches focus only on declarative goals, omitting the hierarchical domain knowledge. In this paper, we propose a novel learning framework to refine HTN methods via task insertion with completely preserving the original methods. As it is difficult to identify incomplete methods without designating declarative goals for compound tasks, we introduce the notion of prioritized preference to capture the incompleteness possibility of methods. Specifically, the framework first computes the preferred completion profile w.r .t.the prioritized preference to refine the incomplete methods. Then it finds the minimal set of refined methods via a method substitution operation. Experimental analysis demonstrates that our approach is effective, especially in solving new HTN planning instances.

The Maximum k-plex Problem is an important combinatorial optimization problem with increasingly wide applications. Due to its exponential time complexity, many heuristic methods have been proposed which can return a good-quality solution in a reasonable time. However, most of the heuristic algorithms are memoryless and unable to utilize the experience during the search. Inspired by the multi-armed bandit (MAB) problem in reinforcement learning (RL), we propose a novel perturbation mechanism named BLP, which can learn online to select a good vertex for perturbation when getting stuck in local optima. To our best of knowledge, this is the first attempt to combine local search with RL for the maximum $ k $-plex problem. Besides, we also propose a novel strategy, named Dynamic-threshold Configuration Checking (DTCC), which extends the original Configuration Checking (CC) strategy from two aspects. Based on the BLP and DTCC, we develop a local search algorithm named BDCC and improve it by a hyperheuristic strategy. The experimental result shows that our algorithms dominate on the standard DIMACS and BHOSLIB benchmarks and achieve state-of-the-art performance on massive graphs.