Realistic and interactive surgical simulation has the potential to facilitate crucial applications, such as medical professional training and autonomous surgical agent training. In the natural visual domain, world models have enabled action-controlled data generation, demonstrating the potential to train autonomous agents in interactive simulated environments when large-scale real data acquisition is infeasible. However, such works in the surgical domain have been limited to simplified computer simulations, and lack realism. Furthermore, existing literature in world models has predominantly dealt with action-labeled data, limiting their applicability to real-world surgical data, where obtaining action annotation is prohibitively expensive. Inspired by the recent success of Genie in leveraging unlabeled video game data to infer latent actions and enable action-controlled data generation, we propose the first surgical vision world model. The proposed model can generate action-controllable surgical data and the architecture design is verified with extensive experiments on the unlabeled SurgToolLoc-2022 dataset.

The integration of deep learning tools in gastrointestinal vision holds the potential for significant advancements in diagnosis, treatment, and overall patient care. A major challenge, however, is these tools' tendency to make overconfident predictions, even when encountering unseen or newly emerging disease patterns, undermining their reliability. We address this critical issue of reliability by framing it as an out-of-distribution (OOD) detection problem, where previously unseen and emerging diseases are identified as OOD examples. However, gastrointestinal images pose a unique challenge due to the overlapping feature representations between in- Distribution (ID) and OOD examples. Existing approaches often overlook this characteristic, as they are primarily developed for natural image datasets, where feature distinctions are more apparent. Despite the overlap, we hypothesize that the features of an in-distribution example will cluster closer to the centroids of their ground truth class, resulting in a shorter distance to the nearest centroid. In contrast, OOD examples maintain an equal distance from all class centroids. Based on this observation, we propose a novel nearest-centroid distance deficit (NCCD) score in the feature space for gastrointestinal OOD detection. Evaluations across multiple deep learning architectures and two publicly available benchmarks, Kvasir2 and Gastrovision, demonstrate the effectiveness of our approach compared to several state-of-the-art methods. The code and implementation details are publicly available at: https://github.com/bhattarailab/NCDD

Alzheimer's Disease (AD) represents one of the most pressing challenges in the field of neurodegenerative disorders, with its progression analysis being crucial for understanding disease dynamics and developing targeted interventions. Recent advancements in deep learning and various representation learning strategies, including self-supervised learning (SSL), have shown significant promise in enhancing medical image analysis, providing innovative ways to extract meaningful patterns from complex data. Notably, the computer vision literature has demonstrated that incorporating supervisory signals into SSL can further augment model performance by guiding the learning process with additional relevant information. However, the application of such supervisory signals in the context of disease progression analysis remains largely unexplored. This gap is particularly pronounced given the inherent challenges of incorporating both event and time-to-event information into the learning paradigm. Addressing this, we propose a novel framework, Time and Event-aware SSL (TE-SSL), which integrates time-to-event and event and data as supervisory signals to refine the learning process. Our comparative analysis with existing SSL-based methods in the downstream task of survival analysis shows superior performance across standard metrics.

The robustness of supervised deep learning-based medical image classification is significantly undermined by label noise. Although several methods have been proposed to enhance classification performance in the presence of noisy labels, they face some challenges: 1) a struggle with class-imbalanced datasets, leading to the frequent overlooking of minority classes as noisy samples; 2) a singular focus on maximizing performance using noisy datasets, without incorporating experts-in-the-loop for actively cleaning the noisy labels. To mitigate these challenges, we propose a two-phase approach that combines Learning with Noisy Labels (LNL) and active learning. This approach not only improves the robustness of medical image classification in the presence of noisy labels, but also iteratively improves the quality of the dataset by relabeling the important incorrect labels, under a limited annotation budget. Furthermore, we introduce a novel Variance of Gradients approach in LNL phase, which complements the loss-based sample selection by also sampling under-represented samples. Using two imbalanced noisy medical classification datasets, we demonstrate that that our proposed technique is superior to its predecessors at handling class imbalance by not misidentifying clean samples from minority classes as mostly noisy samples.

Label noise in medical image classification datasets significantly hampers the training of supervised deep learning methods, undermining their generalizability. The test performance of a model tends to decrease as the label noise rate increases. Over recent years, several methods have been proposed to mitigate the impact of label noise in medical image classification and enhance the robustness of the model. Predominantly, these works have employed CNN-based architectures as the backbone of their classifiers for feature extraction. However, in recent years, Vision Transformer (ViT)-based backbones have replaced CNNs, demonstrating improved performance and a greater ability to learn more generalizable features, especially when the dataset is large. Nevertheless, no prior work has rigorously investigated how transformer-based backbones handle the impact of label noise in medical image classification. In this paper, we investigate the architectural robustness of ViT against label noise and compare it to that of CNNs. We use two medical image classification datasets -- COVID-DU-Ex, and NCT-CRC-HE-100K -- both corrupted by injecting label noise at various rates. Additionally, we show that pretraining is crucial for ensuring ViT's improved robustness against label noise in supervised training.

Noisy labels can significantly impact medical image classification, particularly in deep learning, by corrupting learned features. Self-supervised pretraining, which doesn't rely on labeled data, can enhance robustness against noisy labels. However, this robustness varies based on factors like the number of classes, dataset complexity, and training size. In medical images, subtle inter-class differences and modality-specific characteristics add complexity. Previous research hasn't comprehensively explored the interplay between self-supervised learning and robustness against noisy labels in medical image classification, considering all these factors. In this study, we address three key questions: i) How does label noise impact various medical image classification datasets? ii) Which types of medical image datasets are more challenging to learn and more affected by label noise? iii) How do different self-supervised pretraining methods enhance robustness across various medical image datasets? Our results show that DermNet, among five datasets (Fetal plane, DermNet, COVID-DU-Ex, MURA, NCT-CRC-HE-100K), is the most challenging but exhibits greater robustness against noisy labels. Additionally, contrastive learning stands out among the eight self-supervised methods as the most effective approach to enhance robustness against noisy labels.

Abstract--Medical Vision Language Pretraining (VLP) has recently emerged as a promising solution to the scarcity of labeled data in the medical domain. By leveraging paired/unpaired vision and text datasets through self-supervised learning, models can be trained to acquire vast knowledge and learn robust feature representations. Such pretrained models have the potential to enhance multiple downstream medical tasks simultaneously, reducing the dependency on labeled data. However, despite recent progress and its potential, there is no such comprehensive survey paper that has explored the various aspects and advancements in medical VLP. In this paper, we specifically review existing works through the lens of different pretraining objectives, architectures, downstream evaluation tasks, and datasets utilized for pretraining and downstream tasks. Subsequently, we delve into current challenges in medical VLP, discussing existing and potential solutions, and conclude by highlighting future directions. To the best of our knowledge, this is the first survey focused on medical VLP. Data-driven artificial intelligence (AI) has undergone rapid advancement in recent years, bringing transformative changes to various domains, including computer vision and natural language processing [1]-[5]. The availability of large-scale Figure 1: Various aspects of Medical Vision Language Pretraining data has played a pivotal role in driving this progress. With (VLP) discussed in this paper. AI is no longer confined to single-modality systems; instead, these multimodal datasets can play a crucial role in training there has been a notable shift towards multimodal learning [6]- large-scale, generalized AI models. Similar trends are quickly emerging, even within the In recent years, self-supervised learning has become a medical domain [10]-[13]. There is a particular emphasis on Often, medical experts rely on information from multiple vision-language models in both the general domain [9], [20], modalities for diagnostic decision-making. For instance, [21] and the medical domain [22]-[27], given that vision physicians consider various factors, including medical images, and language are two key data modalities. By employing blood test results, and sensor data, to recommend treatments.

In this paper, we introduce Active Learning framework in Federated Learning for Target Domain Generalisation, harnessing the strength from both learning paradigms. Our framework, FEDALV, composed of Active Learning (AL) and Federated Domain Generalisation (FDG), enables generalisation of an image classification model trained from limited source domain client's data without sharing images to an unseen target domain. To this end, our FDG, FEDA, consists of two optimisation updates during training, one at the client and another at the server level. For the client, the introduced losses aim to reduce feature complexity and condition alignment, while in the server, the regularisation limits free energy biases between source and target obtained by the global model. The remaining component of FEDAL is AL with variable budgets, which queries the server to retrieve and sample the most informative local data for the targeted client. We performed multiple experiments on FDG w/ and w/o AL and compared with both conventional FDG baselines and Federated Active Learning baselines. Our extensive quantitative experiments demonstrate the superiority of our method in accuracy and efficiency compared to the multiple contemporary methods. FEDALV manages to obtain the performance of the full training target accuracy while sampling as little as 5% of the source client's data.

Multimodal Person Reidentification is gaining popularity in the research community due to its effectiveness compared to counter-part unimodal frameworks. However, the bottleneck for multimodal deep learning is the need for a large volume of multimodal training examples. Data augmentation techniques such as cropping, flipping, rotation, etc. are often employed in the image domain to improve the generalization of deep learning models. Augmenting in other modalities than images, such as text, is challenging and requires significant computational resources and external data sources. In this study, we investigate the effectiveness of two computer vision data augmentation techniques: cutout and cutmix, for text augmentation in multi-modal person re-identification. Our approach merges these two augmentation strategies into one strategy called CutMixOut which involves randomly removing words or sub-phrases from a sentence (Cutout) and blending parts of two or more sentences to create diverse examples (CutMix) with a certain probability assigned to each operation. This augmentation was implemented at inference time without any prior training. Our results demonstrate that the proposed technique is simple and effective in improving the performance on multiple multimodal person re-identification benchmarks.

The recent success of multiple neural architectures like CNNs, Transformers, and MLP-Mixers motivated us to look for similarities and differences between them. We found that these architectures can be interpreted through the lens of a general concept of dimension mixing. Research on coupling flows and the butterfly transform shows that partial and hierarchical signal mixing schemes are sufficient for efficient and expressive function approximation. In this work, we study group-wise sparse, non-linear, multi-layered and learnable mixing schemes of inputs and find that they are complementary to many standard neural architectures. Following our observations and drawing inspiration from the Fast Fourier Transform, we generalize Butterfly Structure to use non-linear mixer function allowing for MLP as mixing function called Butterfly MLP. We were also able to mix along sequence dimension for Transformer-based architectures called Butterfly Attention. Experiments on CIFAR and LRA datasets demonstrate that the proposed Non-Linear Butterfly Mixers are efficient and scale well when the host architectures are used as mixing function. Additionally, we propose Patch-Only MLP-Mixer for processing spatial 2D signals demonstrating a different dimension mixing strategy.