Problems in which abnormal or novel situations should be detected can be approached by describing the domain of the class of typical examples. These applications come from the areas of machine diagnostics, fault detection, illness identification or, in principle, refer to any problem where little knowledge is available outside the typical class. In this paper we explain why proximities are natural representations for domain descriptors and we propose a simple one-class classifier for dissimilarity representations. By the use of linear programming an efficient one-class description can be found, based on a small number of prototype objects. This classifier can be made (1) more robust by transforming the dissimilarities and (2) cheaper to compute by using a reduced representation set. Finally, a comparison to a comparable one-class classifier by Campbell and Bennett is given.

We extend recent work on the connection between loopy belief propagation and the Bethe free energy. Constrained minimization of the Bethe free energy can be turned into an unconstrained saddle-point problem. Both converging double-loop algorithms and standard loopy belief propagation can be interpreted as attempts to solve this saddle-point problem. Stability analysis then leads us to conclude that stable fixed points of loopy belief propagation must be (local) minima of the Bethe free energy. Perhaps surprisingly, the converse need not be the case: minima can be unstable fixed points. We illustrate this with an example and discuss implications.

A neurotrophic model for the co-development of topography and ocular dominance columns in the primary visual cortex has recently been proposed. In the present work, we test this model by driving it with the output of a pair of neuronal vision sensors stimulated by disparate moving patterns. We show that the temporal correlations in the spike trains generated by the two sensors elicit the development of refined topography and ocular dominance columns, even in the presence of significant amounts of spontaneous activity and fixed-pattern noise in the sensors.

The similarity between objects is a fundamental element of many learning algorithms. Most nonparametric methods take this similarity to be fixed, but much recent work has shown the advantages of learning it, in particular to exploit the local invariances in the data or to capture the possibly nonlinear manifold on which most of the data lies. We propose a new nonparametric kernel density estimation method which captures the local structure of an underlying manifold through the leading eigenvectors of regularized local covariance matrices.

In the Bayesian approach, regularization is achieved by specifying a prior distribution over the parameters and subsequently averaging over the posterior distribution. This regularization provides not only smoother estimates of the parameters compared to maximum likelihood but also guides the selection of model structures. It was pointed out in [6] that a very large scale parameter of the Dirichlet prior can degrade predictive accuracy due to severe regularization of the parameter estimates. We complement this discussion here and show that a very small scale parameter can lead to poor over-regularized structures when a product of (conjugate) Dirichlet priors is used over multinomial conditional distributions (Section 3). Section 4 demonstrates the effect of the scale parameter and how it can be calibrated. We focus on the class of Bayesian network models throughout this paper.

The responses of cortical sensory neurons are notoriously variable, with the number of spikes evoked by identical stimuli varying significantly from trial to trial. This variability is most often interpreted as'noise', purely detrimental to the sensory system. In this paper, we propose an alternative view in which the variability is related to the uncertainty, about world parameters, which is inherent in the sensory stimulus. Specifically, the responses of a population of neurons are interpreted as stochastic samples from the posterior distribution in a latent variable model. In addition to giving theoretical arguments supporting such a representational scheme, we provide simulations suggesting how some aspects of response variability might be understood in this framework.

A bio-inspired model for an analog programmable array processor (APAP), based on studies on the vertebrate retina, has permitted the realization of complex programmable spatiotemporal dynamics in VLSI. This model mimics the way in which images are processed in the visual pathway, rendering a feasible alternative for the implementation of early vision applications in standard technologies. A prototype chip has been designed and fabricated in a 0.5µm standard CMOS process. Computing power per area and power consumption is amongst the highest reported for a single chip. Design challenges, tradeoffs and some experimental results are presented in this paper.

Here we derive optimal gain functions for minimum mean square reconstruction from neural rate responses subjected to Poisson noise. The shape of these functions strongly depends on the length T of the time window within which spikes are counted in order to estimate the underlying firing rate. A phase transition towards pure binary encoding occurs if the maximum mean spike count becomes smaller than approximately three provided the minimum firing rate is zero. For a particular function class, we were able to prove the existence of a second-order phase transition analytically. The critical decoding time window length obtained from the analytical derivation is in precise agreement with the numerical results.

Inference and adaptation in noisy and changing, rich sensory environments are rife with a variety of specific sorts of variability. Experimental and theoretical studies suggest that these different forms of variability play different behavioral, neural and computational roles, and may be reported by different (notably neuromodulatory) systems. Here, we refine our previous theory of acetylcholine's role in cortical inference in the (oxymoronic) terms of expected uncertainty, and advocate a theory for norepinephrine in terms of unexpected uncertainty. We suggest that norepinephrine reports the radical divergence of bottom-up inputs from prevailing top-down interpretations, to influence inference and plasticity. We illustrate this proposal using an adaptive factor analysis model.

We derive multiplicative updates for solving the nonnegative quadratic programming problem in support vector machines (SVMs). The updates have a simple closed form, and we prove that they converge monotonically to the solution of the maximum margin hyperplane. The updates optimize the traditionally proposed objective function for SVMs. They do not involve any heuristics such as choosing a learning rate or deciding which variables to update at each iteration. They can be used to adjust all the quadratic programming variables in parallel with a guarantee of improvement at each iteration. We analyze the asymptotic convergence of the updates and show that the coefficients of nonsupport vectors decay geometrically to zero at a rate that depends on their margins.