A Neural Network to Detect Homologies in Proteins

Furthemore, sequence similarity often results from common ancestors. Immunoglobulin (Ig) domains are sets of,a-sheets bound 424 Bengio, Bengio, Pouliot and Agin by cysteine bonds and with a characteristic tertiary structure. Such domains are found in many proteins involved in immune, cell adhesion and receptor functions. These proteins collectively form the immunoglobulin superfamily (for review, see Williams and Barclay, 1987). Members of the superfamily often possess several Ig domains.